Clinical and metabolic factors associated with chronic low-grade inflammation in type 2 diabetic patients

Климонтов, Вадим Валерьевич; Tyan, N V; Фазуллина, Ольга Николаевна; Myakina, Natalia E.; Лыков, А. П.; Vi, Konenkov

doi:10.14341/dm7928

Cited by 23 publications

(9 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Also, there is information about no system activation of Il-1β in case of stable and unstable angina. There is opinion that initiation of smoldering inflammation connected with rise of basic hs-СRP leads to insulin resistance and inductors of inflammation are proinflammatory cytokins, specially interleukins IL-6 and IL-1β [16][17][18].…”

Section: Resultsmentioning

confidence: 99%

Specific parameters of lipid spectrum and markers of vascular inflammation in patients with stable angina and significant coronary artery stenosis with or without diabetes mellitus type 2. A prospective follow-up after angioplasty

Petelina¹,

Musikhina²,

Гапон³

et al. 2017

Integr Obesity Diabetes

View full text Add to dashboard Cite

Background: Despite intensive studies of atherosclerosis associated with DM, the mechanisms of the close relationship between diabetes and CAD are not yet fully indicated; as a result, the search and study of other causes, including vascular inflammatory processes, that accelerate and aggravate the development of atherosclerotic vascular lesions and complications is intensively continuing and that identify the relevance of the research problem. Aim:To perform comparative analysis of lipid profile and markers of vascular inflammatory reaction in patients with CAD and stable angina in general groups and identifying the subgroups with significant coronary artery stenosis without and with DM 2 type. To estimate biochemical parameters of blood serum prospectively after angioplasty in subgroups of patients with significant coronary artery stenosis. Materials and methods:97 patients (males and females) aged 60.3 ± 9.8 years with CAD and stable effort angina were studied. Patients were divided into two groups: group 1 (n=64) with CAD, group 2 (n=33) CAD patients with DM 2 type (n=33). According to selective coronary angiography patients in both groups had significant stenosis of one of the coronary arteries with the degree ≥75% of the vessel lumen. Patients with significant coronary artery stenosis in both subgroups underwent coronary angioplasty with the one-type stents with a drug coating. Study of blood plasma laboratory parameters was conducted in the groups of patients initially at the admission before coronary angiography and at the control points -3, 6 and 12 months after angioplasty and stenting. Duration of patients follow-up was 12 ± 1.2 years after angioplasty. Results:In both groups of patients, the excess of the reference values of the lipid profile atherogenic parameters (TC, LDL, VLDL, TG) was detected. Significant excess of the level of vascular inflammation markers (hs-СRP, TNF -α, homocysteine, IL-1β) was registered along with the excess of normal values of MMP-9 and endothelin-1 in the group of patients with CAD with DM type 2 that could indicate more pronounced vascular inflammation in this group. Prospective follow-up showed the maximum increased level of inflammatory markers at the control point "3 months" after angioplasty in both subgroups. In general, within the positive dynamics of the studied parameters, no attainments in target lipid levels (TC, HDL, TG) and markers of inflammation (HF-CRP, MMP-9) were found at the endpoint of follow-up "12 months" that could indicate the persistence of a systemic slow vascular inflammatory response. Conclusions:Systemic inflammatory response is more pronounced in CAD plus DM type 2 patients both in the general group and in a subgroup with significant coronary stenosis. Maximum level of activation of vascular inflammation parameters at the point "3 months" after angioplasty and persistence of a systemic slow vascular inflammatory response to the endpoint of follow-up determine the patients of both subgroups as patients of very high cardiovascular risk...

show abstract

Section: Resultsmentioning

confidence: 99%

Specific parameters of lipid spectrum and markers of vascular inflammation in patients with stable angina and significant coronary artery stenosis with or without diabetes mellitus type 2. A prospective follow-up after angioplasty

Petelina¹,

Musikhina²,

Гапон³

et al. 2017

Integr Obesity Diabetes

View full text Add to dashboard Cite

show abstract

“…The obtained results give further support to the notion that both diabetes and CKD are associated with proinflammatory changes in the cytokine balance. A variety of factors contribute to chronic inflammatory status in diabetes, including hyperglycemia, enhanced glycemic variability, oxidative stress, obesity and adipose tissue dysfunction, and intestinal dysbiosis [75,76]. Likewise, the causes of inflammation in CKD are multifactorial and include imbalance between increased proinflammatory cytokine production (due to multiple sources of inflammatory stimuli such as oxidative stress, acidosis, volume overload, co-morbidities, especially infections) and inadequate removal (due to decreased eGFR) [57].…”

Section: Discussionmentioning

confidence: 99%

Multiplex Bead Array Assay of a Panel of Circulating Cytokines and Growth Factors in Patients with Albuminuric and Non-Albuminuric Diabetic Kidney Disease

Климонтов

Korbut

Орлов

et al. 2020

JCM

Self Cite

View full text Add to dashboard Cite

A panel of cytokines and growth factors, mediating low-grade inflammation and fibrosis, was assessed in patients with type 2 diabetes (T2D) and different patterns of chronic kidney disease (CKD). Patients with long-term T2D (N = 130) were classified into four groups: no signs of CKD; estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 without albuminuria; albuminuria and eGFR ≥60 mL/min/1.73 m2; albuminuria and eGFR <60 mL/min/1.73 m2. Thirty healthy subjects were acted as control. Twenty-seven cytokines and growth factors were assessed in serum by multiplex bead array assay. Serum hs-CRP, urinary nephrin, podocine, and WFDC2 were measured by ELISA. Patients with T2D showed elevated IL-1Ra, IL-6, IL-17A, G-CSF, IP-10, MIP-1α, and bFGF levels; concentrations of IL-4, IL-12, IL-15, INF-γ, and VEGF were decreased. IL-6, IL-17A, G-CSF, MIP-1α, and bFGF correlated negatively with eGFR; IL-10 and VEGF demonstrated negative associations with WFDC2; no relationships with podocyte markers were found. Adjusted IL-17A and MIP-1α were predictors of non-albuminuric CKD, IL-13 predicted albuminuria with preserved renal function, meanwhile, IL-6 and hsCRP were predictors of albuminuria with eGFR decline. Therefore, albuminuric and non-albuminuric CKD in T2D patients are associated with different pro-inflammatory shifts in the panel of circulating cytokines.

show abstract

“…Вместе с тем, имеются сообщения и об отсут-ствии системной активации ИЛ-1 как при стабильной, так и нестабильной стенокардии. Существует мнение, что инициация вялотекущего воспаления, связанная с повышением базового уровня вч-CРБ, ведет к ИР, а ин-дукторами воспаления являются провоспалительные ци-токины, особенно ИЛ-6 и ИЛ-1 [15][16][17][18].…”

Section: материалы и методыunclassified

Lipid profile and markers of vascular inflammation in patients with stable angina in the presence and absence of type 2 diabetes mellitus

et al. 2017

View full text Add to dashboard Cite

Методы. Обследованы 169 пациентов (60,3±9,8 лет) с ИБС, стабильной стенокардией напряжения. Пациенты распределены: 1-я группа -больные ИБС (n=123), 2-я группа -ИБС с СД2 (n=46). Исследованы параметры липид-ного профиля, маркеры сосудистой воспалительной реакции, маркеры эндотелиальной дисфункции. Исследование биохимических параметров проводилось в группах пациентов до проведения коронароангиографии (КАГ). Результаты. В обеих группах пациентов выявлено превышение референсных значений атерогенных параметров ли-пидного профиля (ОХС, ЛПНП, ЛПОНП, ТГ). Зарегистрировано достоверное превышение уровня маркеров сосуди-стого воспаления (вч-СРБ, гомоцистеина, ИЛ-1 ) и нормативных значений ФНО-, ММР-

show abstract

Clinical and metabolic factors associated with chronic low-grade inflammation in type 2 diabetic patients

Cited by 23 publications

References 27 publications

Specific parameters of lipid spectrum and markers of vascular inflammation in patients with stable angina and significant coronary artery stenosis with or without diabetes mellitus type 2. A prospective follow-up after angioplasty

Specific parameters of lipid spectrum and markers of vascular inflammation in patients with stable angina and significant coronary artery stenosis with or without diabetes mellitus type 2. A prospective follow-up after angioplasty

Multiplex Bead Array Assay of a Panel of Circulating Cytokines and Growth Factors in Patients with Albuminuric and Non-Albuminuric Diabetic Kidney Disease

Lipid profile and markers of vascular inflammation in patients with stable angina in the presence and absence of type 2 diabetes mellitus

Contact Info

Product

Resources

About