Clinical and laboratory study of newborns with lower respiratory tract infection due to respiratory viruses

Vieira, Ricardo P.; Diniz, Edna Maria de Albuquerque; Vaz, Flávio A. C.

doi:10.1080/jmf.13.5.341.350

Cited by 20 publications

(24 citation statements)

References 18 publications

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“…The full‐text review resulted in the exclusion of an additional 74 articles. A total of 27 articles encompassing 3215 patients met all the inclusion criteria and were included in the final analysis 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54. Of those 27, only eight studies, with 334 patients, provided the numbers or percentages of each bacterial coinfecting pathogen 28, 32, 33, 34, 38, 43, 46, 47.…”

Section: Resultsmentioning

confidence: 99%

“…All 27 included studies were observational, of which 13 (1218 patients) were prospective studies,30, 32, 33, 36, 40, 41, 43, 44, 48, 49, 50, 51, 52 and 14 (1997 patients) were retrospective analyses (Table 1). The majority (21) of studies were cohort studies, and the rest were case–control studies.…”

Section: Resultsmentioning

confidence: 99%

“…Most studies enrolled only adults, although the lower age cutoffs varied (e.g., some studies considered adults older than 14 while others used 21). Only seven studies (1214 patients) focused on young children or newborns,29, 31, 38, 46, 49, 51, 54 and two studies (504 patients) included both children and adults 42, 53. Severity of illness varied among studies, but all were focused on hospitalized patients, suggesting a greater than average severity.…”

Section: Resultsmentioning

confidence: 99%

“…Severity of illness varied among studies, but all were focused on hospitalized patients, suggesting a greater than average severity. Eleven of the studies (1007 patients) focused exclusively on patients initially enrolled in an intensive care unit (ICU),32, 34, 35, 38, 39, 41, 42, 44, 46, 47, 51 10 enrolled non‐ICU hospitalized patients (973 patients),30, 33, 36, 37, 40, 43, 45, 49, 53, 54 3 enrolled patients in the emergency department (ED; 135 patients),28, 48, 50 and 2 enrolled patients in a mix of inpatient and outpatient settings (1100 patients) 29, 52. The median sample size was 51 (IQR, 18·5–101), and the mean was 119 (SD: 203), which was driven by three large studies29, 44, 53 that contributed 1958 (61%) of the total number of patients included in this analysis.…”

Section: Resultsmentioning

confidence: 99%

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The frequency of influenza and bacterial coinfection: a systematic review and meta‐analysis

Klein

Monteforte

Gupta

et al. 2016

Influenza Resp Viruses

425

350

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AimCoinfecting bacterial pathogens are a major cause of morbidity and mortality in influenza. However, there remains a paucity of literature on the magnitude of coinfection in influenza patients.MethodA systematic search of MeSH, Cochrane Library, Web of Science, SCOPUS, EMBASE, and PubMed was performed. Studies of humans in which all individuals had laboratory confirmed influenza, and all individuals were tested for an array of common bacterial species, met inclusion criteria.ResultsTwenty‐seven studies including 3215 participants met all inclusion criteria. Common etiologies were defined from a subset of eight articles. There was high heterogeneity in the results (I 2 = 95%), with reported coinfection rates ranging from 2% to 65%. Although only a subset of papers were responsible for observed heterogeneity, subanalyses and meta‐regression analysis found no study characteristic that was significantly associated with coinfection. The most common coinfecting species were Streptococcus pneumoniae and Staphylococcus aureus, which accounted for 35% (95% CI, 14%–56%) and 28% (95% CI, 16%–40%) of infections, respectively; a wide range of other pathogens caused the remaining infections. An assessment of bias suggested that lack of small‐study publications may have biased the results.ConclusionsThe frequency of coinfection in the published studies included in this review suggests that although providers should consider possible bacterial coinfection in all patients hospitalized with influenza, they should not assume all patients are coinfected and be sure to properly treat underlying viral processes. Further, high heterogeneity suggests additional large‐scale studies are needed to better understand the etiology of influenza bacterial coinfection.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

The frequency of influenza and bacterial coinfection: a systematic review and meta‐analysis

Klein

Monteforte

Gupta

et al. 2016

Influenza Resp Viruses

425

350

View full text Add to dashboard Cite

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“…11 CRP levels, initially normal, later became elevated. However, elevated CRP levels have been described with influenza infections 7,12 in neonates, making this a poor marker for differentiation from bacterial infections. Chest radiographs showed consolidation and air bronchograms suggestive of a bacterial infection and later, an interstitial pattern, suggestive of viral pneumonitis.…”

Section: Discussionmentioning

confidence: 99%

Fatal influenza B virus pneumonia in a preterm neonate: case report and review of the literature

2007

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Unrecognized Viral Respiratory Tract Infections in Premature Infants during their Birth Hospitalization: A Prospective Surveillance Study in Two Neonatal Intensive Care Units

Bennett

Tabarani

Bartholoma

et al. 2012

The Journal of Pediatrics

101

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Objective We sought to determine the frequency and effects of nosocomial respiratory viral infections (RVIs) in premature neonates, including those who may be asymptomatic. Study Design We performed a year-long surveillance for RVIs in infants <33 weeks gestational age admitted to two Syracuse neonatal intensive care units (NICUs). Infants were enrolled within 3 days of NICU admission and were sampled for RVIs until discharge using a multiplex PCR assay capable of detecting 17 different respiratory viruses or subtypes. Results 26 of 50 prematurely born infants (52%) tested positive for a respiratory virus at least once during their birth hospitalization. Testing positive for a respiratory virus was significantly associated with longer length of stay (70 days vs. 35 days, p = 0.002) and prolonged ventilatory support (51 vs. 13 days, p = 0.002). Infants who tested positive for a respiratory virus during their birth hospitalization had more than twice the rate of developing bronchopulmonary dysplasia (BPD; p < 0.05). Conclusion Nosocomial RVIs were frequent in our study population, despite the absence of clinical indicators of illness. Length of hospital stay was significantly longer and a diagnosis of BPD was more common in those premature infants who had respiratory viruses detected.

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Clinical and laboratory study of newborns with lower respiratory tract infection due to respiratory viruses

Abstract: It was observed that, although the majority of viral respiratory infections had a favorable course, some patients presented a serious and prolonged clinical manifestation, especially when there was concomitant bacterial infection.

Cited by 20 publications

References 18 publications

The frequency of influenza and bacterial coinfection: a systematic review and meta‐analysis

The frequency of influenza and bacterial coinfection: a systematic review and meta‐analysis

Fatal influenza B virus pneumonia in a preterm neonate: case report and review of the literature

Unrecognized Viral Respiratory Tract Infections in Premature Infants during their Birth Hospitalization: A Prospective Surveillance Study in Two Neonatal Intensive Care Units

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