Clinical and Laboratory Profile of Hospitalized Symptomatic COVID-19 Patients: Case Series Study From the First COVID-19 Center in the UAE

Hannawi, Suad; Hannawi, Haifa; Naeem, Kashif; Elemam, Noha Mousaad; Hachim, Mahmood Y.; Hachim, Ibrahim Y.; Darwish, Abdulla Salah; Salmi, Issa Al

doi:10.3389/fcimb.2021.632965

Cited by 22 publications

(27 citation statements)

References 41 publications

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“…The results coincide with other studies wherein it has been reported that fever, cough, fatigue, and shortness of breath are common symptoms in severe COVID-19 patients (Durrani et al 2020;Al Mutair et al 2020). The association of the lower respiratory system in affecting the severity of COVID-19 patients has also been reported in different studies (Brosnahan et al 2020;Hannawi et al 2021;Marinari, Danny, and Miller 2019).…”

Section: Clinical Featuressupporting

confidence: 90%

“…The results of this study are in line with contrasting findings in similar studies. The increase of CRP and ferritin in critically ill COVID-19 patients has been measured in various findings (Hannawi et al 2021;Al Mutair et al 2020;Wang et al 2020). The same tendency was observed for WBC, platelets, neutrophils, and bilirubin (Taj et al 2021;Yegorov et al 2021;Yin et al 2020).…”

Section: Laboratory Parametersmentioning

confidence: 99%

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Epidemiology, Clinico-Pathological Characteristics, and Comorbidities of SARS-CoV-2 infected Pakistani Patients

Omer

Sarwar

Roman

et al. 2021

Preprint

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SARS-CoV-2 is a causative agent for COVI-19 disease, initially reported from Wuhan, China. Infected Patients experienced mild to severe symptoms, resulting in several fatalities due to a weak understanding of its pathogenesis, which is the same even to date. This cross-sectional study has been designed on four hundred and fifty-two symptomatic, mild-to-moderate, and severe/critical patients to understand the epidemiology and clinical characteristics of COVID-19 patients with their comorbidities and response to treatment. The mean age of studied patients was (58±14.42) years, and the overall male to female ratio was 61.7 to 38.2%, respectively. 27.3% of the patients had a history of exposure, 11.9% travel history, while for 60% of patients, the source of infection was unknown. The most prevalent signs and symptoms in ICU patients were dry coughs, myalgias, shortness of breath, gastrointestinal discomfort, and abnormal Chest X-ray (p<0.001), along with the high percentage of hypertension (p=0.007) and COPD (p=0.029) as leading comorbidities. Complete Blood Counts indicators were significantly increased in severe patients, while the Coagulation Profile and D-dimer values were significantly higher in mild-to-moderate (non-ICU) patients (p < 0.001). Serum Creatinine (1.22 umole L-1; p = 0.016) and LDH (619 umol L-1; p < 0.001) indicators were significantly high in non-ICU patients while, raised values of Total Bilirubin (0.91 umol L-1; p = 0.054), CRP (84.68 mg L-1; p = 0.001) and Ferritin (996.81 mg L-1; p < 0.001) were found in ICU patients. Drug Dexamethasone was the leading prescribed and administrated medicine to the COVID-19 patients, followed by Remdesivir, Meropenem, Heparin, and Tocilizumab, respectively. A characteristic pattern of Ground glass opacities (GGO), consolidation, and interlobular septal thickening were prominent in severely infected patients. These findings could be used for future research, control, and prevention of SARS-CoV-2 infected patients.

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Section: Clinical Featuressupporting

confidence: 90%

Section: Laboratory Parametersmentioning

confidence: 99%

Epidemiology, Clinico-Pathological Characteristics, and Comorbidities of SARS-CoV-2 infected Pakistani Patients

Omer

Sarwar

Roman

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…The presence of organ failure or injury was considered according to a criteria previously described [ 8 ]: Acute cardiac injury was defined as the presence of at least one documented elevated high-sensitivity troponin-I. Acute kidney injury was defined as patient having a raise in the serum creatinine of ≥26.5 μmol/liter within 48 h.; or increase in serum creatinine ≥1.5 times than the baseline that occurred within the preceding 7 days; or if there were reduction in the urine volume <0.5 ml/kg/hr.…”

Section: Methodsmentioning

confidence: 99%

The inflammatory biomarkers profile of hospitalized patients with COVID-19 and its association with patient’s outcome: A single centered study

Hachim

Hannawi

et al. 2021

PLoS ONE

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Several reports highlighted the central role of inflammation in the pathogenesis of corona virus disease-19 (COVID-19) disease. Also, the hyper-inflammatory response that is triggered by severe acute respiratory syndrom-Covid-2 (SARS-CoV-2) infection was believed to play an essential role in disease severity and adverse clinical course. For that reason, the classical inflammatory markers were proposed as a possible indicator for COVID-19 severity. However, an extensive analysis of the predictive value of inflammatory biomarkers in large patients’ cohorts is still limited and critically needed. In this study we investigated the predictive value of the classical inflammatory biomarkers in a patient cohort consists of 541 COVID-19 patients admitted to Al Kuwait Hospital, Dubai, UAE. A detailed analysis of the association between the essential inflammatory markers and clinical characteristics as well as clinical outcome of the patients were made. In addition, the correlation between those markers and a wide range of laboratory biomarkers and incidence of acute organs injury were investigated. Our results showed a significant elevation of many inflammatory markers including white cell count (WBC) count, neutrophils count, C-reactive protein (CRP), D-Dimer, ferritin, procalcitonin (PCT), and lactate dehydrogenase (LDH) levels in patients with more severe illness. Also, our results highlighted that higher levels of those markers can predict worse patient outcome including the need of ventilation, intensive care unit (ICU) admission, multiple organs dysfunction as well as death. In addition, Our results showed that the presence of lymphopenia and lower absolute lymphocyte count (ALC) at the time of admission were associated with severe to critical COVID-19 illness (P<0.0001), presence of acute respiratory distress syndrome (ARDS) (P<0.0001) and the need for ventilation and ICU admission., Moreover, our results showed a strong association between lower ALC count and multiple organs dysfunction and patient’s death (P<0.0001). In conclusion, our results highlighted the possible use of classical inflammatory biomarkers at time of admission as a potential predictive marker for more severe clinical course in COVID-19 patients that might need more aggressive therapeutic approach including the need of ventilators and ICU admission. The presence of such predictive markers might improve patient’s stratification and help in the direction of the available resources to patients in need, which in turn help in improving our response to the disease pandemic.

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“…As of 1st December 2021, UAE reported a total of 742,278 PCR confirmed COVID-19 cases, with only 2148 deaths (CMR: 0.289%) ( Ritchie et al, 2020 ). Majority of the patients with severe disease were males, often with one or more commodities, such as diabetes, hypertension, obesity, liver and cardiovascular diseases ( Hannawi et al, 2021 ; Hosani et al, 2021 ). Notably, the mean age of UAE cases tended to be lower than that reported in many other countries, reflecting the younger population of the country.…”

Section: Factors Contributing To Low Mortality Rate Of Covid-19 In Uaementioning

confidence: 99%

Global data analysis and risk factors associated with morbidity and mortality of COVID-19

et al. 2022

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This review was focused on global data analysis and risk factors associated with morbidity and mortality of coronavirus disease 2019 from different countries, including Bangladesh, Brazil, China, Central Eastern Europe, Egypt, India, Iran, Pakistan, and South Asia, Africa, Turkey and UAE. Male showed higher confirmed and death cases compared to females in most of the countries. In addition, the case fatality ratio (CFR) for males was higher than for females. This gender variation in COVID-19 cases may be due to males' cultural activities, but similar variations in the number of COVID-19 affected males and females globally. Variations in the immune system can illustrate this divergent risk comparatively higher in males than females. The female immune system may have an edge to detect pathogens slightly earlier. In addition, women show comparatively higher innate and adaptive immune responses than men, which might be explained by the high density of immune-related genes in the X chromosome. Furthermore, SARS-CoV-2 viruses use angiotensin-converting enzyme 2 (ACE2) to enter the host cell, and men contain higher ACE2 than females. Therefore, males may be more vulnerable to COVID-19 than females. In addition, smoking habit also makes men susceptible to COVID-19. Considering the age-wise distribution, children and older adults were less infected than other age groups and the death rate. On the contrary, more death in the older group may be associated with less immune system function. In addition, most of these group have comorbidities like diabetes, high pressure, low lungs and kidney function, and other chronic diseases. Due to the substantial economic losses and the numerous infected people and deaths, research examining the features of the COVID-19 epidemic is essential to gain insight into mitigating its impact in the future and preparedness for any future epidemics.

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Clinical and Laboratory Profile of Hospitalized Symptomatic COVID-19 Patients: Case Series Study From the First COVID-19 Center in the UAE

Cited by 22 publications

References 41 publications

Epidemiology, Clinico-Pathological Characteristics, and Comorbidities of SARS-CoV-2 infected Pakistani Patients

Epidemiology, Clinico-Pathological Characteristics, and Comorbidities of SARS-CoV-2 infected Pakistani Patients

The inflammatory biomarkers profile of hospitalized patients with COVID-19 and its association with patient’s outcome: A single centered study

Global data analysis and risk factors associated with morbidity and mortality of COVID-19

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