Clinical and laboratory presentation of von Willebrand disease: Experience from a single center in Saudi Arabia

Owaidah, Tarek; Alharbi, Muhammed; Mandourah, Mohammed; Saleh, Mahasen; Almusa, Abdulrahman; Alnounou, Randa; Al-Zahrani, Hazza; Khogeer, Haithm

doi:10.1016/j.jtumed.2022.10.019

Cited by 2 publications

(2 citation statements)

References 39 publications

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“…The significantly lower vWF: Ag levels among blood group O compared to non-O individuals recorded in this study corroborate with previous studies in Nigeria [16,22], southern India [5], and Saudi Arabia [21,26]. Variations in the levels of vWF: Ag were observed among the ABO blood groups.…”

Section: Discussionsupporting

confidence: 91%

Plasma von Willebrand Factor Antigen Levels and Its Relation with ABO Blood Group, Age and Sex

et al. 2022

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Background: The ABO blood antigens may influence the levels of vWF: Ag and put individuals at risk of coagulopathies. This study assessed the plasma vWF: Ag and its relation with ABO blood antigens among healthy adults in northern Ghana. Methods: This cross-sectional study recruited 84 blood donors, aged 18–50 years, at Tamale Teaching Hospital. Blood groups were determined using the standard tube method, and a complete blood count was measured with an automated haematology analyzer. Sandwich ELISA was used to assess plasma vWF: Ag levels. The data obtained were analyzed using SPSS version 22. Results: The frequencies of O, A, B, and AB blood groups were 34 (40.5%), 25 (29.8%), 20 (23.8%), and 5 (6.0%), respectively. vWF: Ag levels were higher among the non-O than group O individuals (p = 0.008). Plasma vWF: Ag levels were lower in group O compared to AB (p = 0.015) and A (p = 0.013) individuals. Males had higher vWF: Ag levels than females (p = 0.002). A moderately positive correlation was observed between age and vWF levels (r = 0.497, p<0.001). Blood group O participants had lower absolute neutrophil counts (p = 0.039), but higher RDW-SD (p = 0.045). Conclusion: The predominant blood group was O, followed by other groups in the order: O>A>B>AB. Plasma vWF: Ag levels were higher in non-group O compared with group O individuals. Males had higher vWF: Ag levels, and a positive correlation between age and vWF: Ag was observed. Again, blood group O participants had lower neutrophil counts, but higher RDW-SD. The relationship between ABO blood phenotypes and plasma vWF: Ag should be considered in clinical practice. The establishment of separate reference intervals of vWF: Ag for the various phenotypes of ABO is recommended. Also, the study recommends further multicenter studies to assess the link between ABO phenotypes and all the endothelial cell parameters. Doi: 10.28991/SciMedJ-2022-04-02-02 Full Text: PDF

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Section: Discussionsupporting

confidence: 91%

Plasma von Willebrand Factor Antigen Levels and Its Relation with ABO Blood Group, Age and Sex

et al. 2022

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“…In relevance to blood group types, the variance analysis revealed a significant correlation between vWF:Ag, vWF:RCo, and FVIII levels and the blood type. There was a significant difference between FVIII and vWF:Ag in O and non-O groups with a greater difference for vWF:RCo indicating that people with AB blood groups tend to have higher levels of vWF [18].…”

Section: Rare Bleeding Disordersmentioning

confidence: 90%

Bleeding disorders in Saudi Arabia, causes and prevalence: a review

Belali

2024

Blood Coagulation &Amp; Fibrinolysis

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As bleeding disorders are a worldwide health concern, Saudi Arabia is experiencing a notable prevalence of such disorders. Studying the frequency and cause of hemostatic disorders is the key to successful clinical interventions and instigating effective public policies that limit the spread of such disorders. The current review aims to highlight the major findings of the body of literature that has investigated the causes, prevalence, and major challenges associated with bleeding disorders in the country. The current review summarizes the major findings of different studies that have been conducted in Saudi Arabia regarding different bleeding disorders. Multiple causes and symptoms of bleeding disorders have been reported by different studies. Some studies investigated the genetic aspect of bleeding disorders and revealed specific mutations in coagulation factor genes influencing the symptoms of different bleeding disorders. Moreover, rare bleeding disorders such as Glanzmann thrombasthenia and Henoch–Schönlein purpura, have been reported in different regions of Saudi Arabia. Combining clinical presentations, genetic factors, and epidemiological data, the current review of the literature provides a comprehensive insight into bleeding disorders in the kingdom. This will help in advancing the diagnostic capabilities and genetic counseling enhancing management strategies and therapeutic interventions benefiting bleeding disorder patients and the kingdom.

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Clinical and laboratory presentation of von Willebrand disease: Experience from a single center in Saudi Arabia

Cited by 2 publications

References 39 publications

Plasma von Willebrand Factor Antigen Levels and Its Relation with ABO Blood Group, Age and Sex

Plasma von Willebrand Factor Antigen Levels and Its Relation with ABO Blood Group, Age and Sex

Bleeding disorders in Saudi Arabia, causes and prevalence: a review

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