Clinical and Laboratory Potential Predictors of Blood Culture Positivity in Under Five Children with Clinically Severe Pneumonia - Khartoum -Sudan

Salih, Karimeldin Mohamed Ali; El-Samani, El-Fatih; Bilal, Jalal Ali; Eldouch, Widad; Ibrahim, Safaa A.

doi:10.7860/jcdr/2015/13771.6377

Cited by 5 publications

(6 citation statements)

References 24 publications

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“…Through strict screening criteria, we finally included 75 studies (n=18 379) published between 1985 and 2022 in our meta-analysis (figure 1). Among the studies included, 53 studies reported data for adults (n=10 404),4 29 30 32–81 17 studies for children (n=6652)29 35 82–96 and 7 studies for mixed groups (n=1323)97–103 (online supplemental material 2 and table 1). Forty-eight reported data for Chlamydia (n=12 087)4 30 32–34 39–42 44 46 48–50 53 56 58 60–65 67–70 72 74 75 78–82 84–88 90 91 93 97–99 101 102, 61 for Mycoplasma (n=15 101)4 30 32–34 36 37 39–50 53–58 60–70 72 74 79–91 93–102 and 56 for Legionella (n=11 144) 4 30 32–34 36–50 52 55 56 58–65 67–70 72–81 84 86 87 92 93 97–101 103.…”

Section: Resultsmentioning

confidence: 99%

“…It should be noted that there were four studies29 52 80 98 that considered the prevalence of Mycoplasma and Chlamydia as a whole, and we could not obtain more detailed information on their respective prevalence rate; we then excluded this study when calculating the pooled prevalence of either Chlamydia or Mycoplasma . Moreover, 27 of the 75 studies were from Asia,29 43 53 54 59 63 64 67 68 70 75–78 81–83 89 92–96 99–102 28 from Europe,30 32–34 37–42 44–47 50–52 56 57 60 61 65 66 71 72 74 97 98 9 from Africa,35 36 62 73 84–87 91 4 from South America,48 55 69 88 3 from North America,4 49 79 2 from Australia58 103 and 2 studies80 90 did not present the exact continents.…”

Section: Resultsmentioning

confidence: 99%

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Prevalence of atypical pathogens in patients with severe pneumonia: a systematic review and meta-analysis

et al. 2023

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ObjectivesWe aimed to summarise the prevalence of atypical pathogens in patients with severe pneumonia to understand the prevalence of severe pneumonia caused by atypical pathogens, improve clinical decision-making and guide antibiotic use.DesignSystematic review and meta-analysis.Data sourcesPubMed, Embase, Web of Science and Cochrane Library were searched through November 2022.Eligibility criteriaEnglish language studies enrolled consecutive cases of patients diagnosed with severe pneumonia, with complete aetiological analysis.Data extraction and synthesisWe conducted literature retrieval on PubMed, Embase, Web of Science and The Cochrane Library to estimate the prevalence ofChlamydia,MycoplasmaandLegionellain patients with severe pneumonia. After double arcsine transformation of the data, a random-effects model was used for meta-analyses to calculate the pooled prevalence of each pathogen. Meta-regression analysis was also used to explore whether the region, different diagnostic method, study population, pneumonia categories or sample size were potential sources of heterogeneity.ResultsWe included 75 eligible studies with 18 379 cases of severe pneumonia. The overall prevalence of atypical pneumonia is 8.1% (95% CI 6.3% to 10.1%) In patients with severe pneumonia, the pooled estimated prevalence ofChlamydia,MycoplasmaandLegionellawas 1.8% (95% CI 1.0% to 2.9%), 2.8% (95% CI 1.7% to 4.3%) and 4.0% (95% CI 2.8% to 5.3%), respectively. We noted significant heterogeneity in all pooled assessments. Meta-regression showed that the pneumonia category potentially influenced the prevalence rate ofChlamydia. The mean age and the diagnostic method of pathogens were likely moderators for the prevalence ofMycoplasmaandLegionella, and contribute to the heterogeneity of their prevalence.ConclusionsIn severe pneumonia, atypical pathogens are notable causes, especiallyLegionella. The diagnostic method, regional difference, sample size and other factors contribute to the heterogeneity of prevalence. The estimated prevalence and relative heterogeneity factors can help with microbiological screening, clinical treatment and future research planning.PROSPERO registration numberCRD42022373950.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Prevalence of atypical pathogens in patients with severe pneumonia: a systematic review and meta-analysis

et al. 2023

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“…The characteristics of the included studies are depicted in (Table 1), among which the oldest were published in 2011 [23] while the most recent one was published in 2022 [20] . Eleven research articles determining pneumonia prevalence or risk factors conducted in Khartoum State [12,[14][15][16][17][20][21][22][23][24][25][26] , two in Gezira State [18,19] and one in South Darfur State [13] . Moreover, almost all articles were conducted among both gender, nevertheless, one study recruited females only (mothers of infected children) [18] while another study did not determine the gender of their participants…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Furthermore, 10 articles were concerned of pneumonia prevalence/risk factors among children [14,15,[17][18][19][22][23][24][25][26] . All characteristics of included studies are depicted in (Table 1).…”

Section: Study Characteristicsmentioning

confidence: 99%

Pneumonia in Sudan; Systematic Scoping Review of Literature and Meta Analysis

Mohamed

SalahEldin

Idris

et al. 2022

Preprint

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In addition to excessive burden of non-communicable diseases, natural and manmade disasters and internal conflicts, Sudan is predominantly susceptible to communicable diseases such as Malaria, Tuberculosis, and Pneumonia, which bring about a burden of infectious diseases and demand for high quality health care. According to the WHO as well as the Sudan Health Observatory, Pneumonia is one of the leading causes of death in Sudan. This study therefore aimed to determine pneumonia infection prevalence among Sudanese as well as its related risk factors. A systematic review of the literature was conducted in the 1st of December 2020. The review was regulated in accordance with PRISMA. After abstract and full text screening only seventeen articles met our inclusion criteria and passed the quality assessment procedure. Seven included studies determined prevalence of pneumonia; the overall pooled prevalence was around 30%. Furthermore, twelve research articles investigated risk factors related to pneumonia among Sudanese population. Further research with larger sample sizes targeting risk factors of pneumonia among Sudanese population is needed to be conducted. Keywords Africa, Developing countries, Risk, STIs, sub-Saharan Africa

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“…Therefore, CRP, procalcitonin (PCT) and interleukin-6 (IL-6) are more informative for the early diagnosis of neonatal EOS. High CRP status is indicative of severe bacterial infections and is associated with an increased risk of EOS [2,[8][9][10]. Salih et al reported [9] that when CRP is ≥ 8 mg/L, it can be used as one of the reference factors for diagnosing positive blood cultures.…”

Section: Introductionmentioning

confidence: 99%

Factors influencing C-reactive protein status on admission in neonates after birth

Cao,

Wang,

Liu

et al. 2024

BMC Pediatr

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Objective To explore the factors influencing C-reactive protein (CRP) status in neonates on admission after birth. Methods 820 newborns born and hospitalized at Xiangya Hospital of Central South University from Jan. 2020 to Dec. 2020 were retrospectively analyzed. Maternal medical history and medication use during pregnancy, neonatal demographic information and status at birth were collected through the electronic medical record system. Statistical software was used to analyze the possible relationship between perinatal factors and CRP on admission after birth. Results A total of 820 neonates were analyzed, including 463 males and 357 females with a mean gestational age (GA) of 36.07 ± 3.30 weeks. (1) Multifactor Logistic regression analysis: larger GA (OR: 1.13, 95%CI: 1.00-1.28, P = 0.042), premature rupture of membranes (PROM) ≥ 18 h (OR: 2.39, 95%CI: 1.35–4.23, P = 0.003) and maternal autoimmune diseases (OR: 5.30, 95%CI: 2.15–13.07, P < 0.001) were independent risk factors for CRP ≥ 8 mg/L. Cesarean delivery (OR 0.40, 95%CI: 0.26–0.60, P < 0.001) was independent protective factor for CRP ≥ 8 mg/L. (2) Threshold effect analysis: A non-linear relationship was found between GA and CRP. When GA is less than 33.9 weeks, the risk of CRP ≥ 8 mg/L was reduced by 28% with one week increased (P < 0.001), and when GA is more than 33.9 weeks, the risk of CRP ≥ 8 mg/L was increased by 61% with one week increased (P < 0.001). Conclusions GA, PROM, maternal autoimmune diseases and cesarean delivery were all independent influences neonatal CRP ≥ 8 mg/L on admission, and there was a nonlinear relationship between GA and neonatal CRP ≥ 8 mg/L on admission.

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Clinical and Laboratory Potential Predictors of Blood Culture Positivity in Under Five Children with Clinically Severe Pneumonia - Khartoum -Sudan

Cited by 5 publications

References 24 publications

Prevalence of atypical pathogens in patients with severe pneumonia: a systematic review and meta-analysis

Prevalence of atypical pathogens in patients with severe pneumonia: a systematic review and meta-analysis

Pneumonia in Sudan; Systematic Scoping Review of Literature and Meta Analysis

Factors influencing C-reactive protein status on admission in neonates after birth

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