Clinical and laboratory findings of Babesia infection in dogs

Reddy, B. Sudhakara; Sivajothi, S.; Reddy, L.S.S. Varaprasad; Raju, K. G. S.

doi:10.1007/s12639-014-0491-x

Cited by 25 publications

(6 citation statements)

References 14 publications

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“…There are six species of Babesia that are currently recognized in dogs [5]; three are the large piroplasms (4–5 µm) of B. canis , B. vogeli , and B. rossi and three are the small piroplasms (1–3 µm), B. gibsoni, B. vulpes , and B. conradae. Babesiosis is a significant tick-born disease of dogs [6]. The objective of the present study was to analyze the genetic diversity of Babesia species infecting selected dogs at three clinics of Lahore and one of Narowal.…”

Section: Introductionmentioning

confidence: 99%

Genetic Diversity of Canine Babesia Species Prevalent in Pet Dogs of Punjab, Pakistan

Tayyub

Ashraf

Lateef

et al. 2019

Animals

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Canine babesiosis is a serious threat to dogs’ health worldwide, caused by the intra-erythrocytic Babesia species. The present study was carried out in pet dogs presented at three clinics of Lahore and one of Narowal in Punjab, Pakistan. Two hundred blood samples (50 from each clinic) were collected and screened by microscopy for Babesia spp. Out of 200 samples, 84 (42%) were found to be positive for babesiosis. The highest number of positive cases (50%) was recorded in dogs at Narowal clinic. Non-significant variation (p > 0.05) was observed in the prevalence of babesiosis in dogs in relation to sex and age. Positive samples were further confirmed by a polymerase chain reaction using 18S-rRNA genus-specific and species-specific primers. Amplicons were further analyzed by nucleotide sequencing for genetic diversity. Babesia canis and gibsoni were confirmed by genome sequencing in all diseased dogs. These isolates closely resembled each other, but differed from previous reported strains. In conclusion, pet dogs suffering from babesiosis were infected with B. canis and gibsoni, while in other countries, other Babesia species are also prevalent.

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Section: Introductionmentioning

confidence: 99%

Genetic Diversity of Canine Babesia Species Prevalent in Pet Dogs of Punjab, Pakistan

Tayyub

Ashraf

Lateef

et al. 2019

Animals

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“…Bilwal et al 29 reported no significant differences in the values of total serum proteins between dogs with babesiosis and healthy dogs. Reddy et al 31 found in dogs infected with large Babesia parasites a significant reduction in total serum protein concentrations. On the other hand, Yogeshpriya et al 30 obtained in dogs naturally infected with B. gibsoni about 10 g/l higher total serum protein values than in healthy dogs, but these differences were not significant.…”

Section: Discussionmentioning

confidence: 98%

Differences in serum protein electrophoretic pattern in dogs naturally infected with Babesia gibsoni and Babesia canis

Tóthová

Karasová

Blaňárová

et al. 2020

Sci Rep

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Canine babesiosis may cause several hematological and biochemical changes, but only limited studies are available regarding the possible differences of changes in animals infected by different Babesia parasites. The study focused on the evaluation of the differences in serum protein electrophoretic pattern between dogs naturally infected with B. gibsoni (17 dogs) and B. canis (40 dogs). The mean values of total proteins, β1-, β2- and γ-globulins were in dogs infected with B. gibsoni significantly higher (P < 0.05 and P < 0.001) than in dogs infected with B. canis. The relative concentrations of albumin, α1-, α2-globulins and the A/G ratios were in the B. gibsoni infected dogs significantly lower (P < 0.001), no significant differences were found in the relative concentrations of β1- and β2-globulins. Significant differences were found in most of the evaluated parameters when comparing the results in relation to the form of B. canis infection to B. gibsoni infection. Hematological indices showed significant differences between dogs infected with B. gibsoni and the complicated form of B. canis infection. In conclusion, the obtained results suggest differences in the changes of serum protein electrophoretic pattern between dogs infected with both Babesia species and thus, in the response to the infection caused by various Babesia parasites.

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“…gamonts in the blood of bears with high ESR and globulin values. Notably, changes in albumin, globulin, and ALP levels have also observed in other Babesia -infected hosts, such as camels ( Camelus dromedarius ) [ 53 ], dogs ( Canis familiaris ) [ 54 ], and cattle [ 55 ] as well as Hepatozoon -infected dogs [ 56 – 58 ]. Collectively, these hematological and plasma data may serve as a reference for future investigation on host and tick-borne pathogen relationships in wild bears.…”

Section: Discussionmentioning

confidence: 99%

Hematological and plasma profiles and ticks and tick-borne pathogens in wild Formosan black bears (Ursus thibetanus formosanus)

Tsai,

Wechtaisong,

Lee

et al. 2024

Parasites Vectors

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Background The endangered Formosan black bear (Ursus thibetanus formosanus) is the largest native carnivorous mammal in Taiwan. Diseases, poor management, illegal hunting, and habitat destruction are serious threats to the survival of bear populations. However, studies on the impact of diseases on bear populations are limited. Therefore, this study aimed to establish a database of the hematological and plasma profiles of free-ranging Formosan black bears and investigate the occurrence of ectoparasites, blood parasites, and vector-borne pathogens. Methods Formosan black bears were captured in Yushan National Park (YNP) and Daxueshan Forest Recreation Area (DSY) in Taiwan. Blood samples were collected from each bear for hematological analysis and plasma biochemistry using a hematology analyzer. Parasites and pathogens were detected using a thin blood smear with Wright–Giemsa staining and polymerase chain reaction (PCR) assay. Additionally, macroscopic ectoparasites were collected from bears to detect blood parasites and other pathogens. Moreover, the relationships between the bear variables (sex, age, and occurrence of parasites or pathogens), ectoparasites, and infectious agents were also analyzed. Results In all, 21 wild bears (14 in YNP and 7 in DSY) were captured and released during the satellite tracking studies. Hematological analysis and plasma biochemistry indicated significant differences in white blood cells (WBC), segments, creatine kinase (CK), and lactate dehydrogenase (LDH) levels between foot snare and culvert-captured bears. Additionally, there were significant differences in total plasma protein (TPP), creatinine, Ca2+, Mg2+, and K+ levels between male and female bears. Moreover, pathogen-infected bears had significantly higher erythrocyte sedimentation rate (ESR; 30 min and 1 h) and globulin levels than uninfected bears. In total, 240 ticks were collected from 13 bears, among which eight adult tick species were identified, including Haemaphysalis flava, Haemaphysalis hystricis, Amblyomma testudinarium, Ixodes ovatus, Dermacentor taiwanensis, Haemaphysalis longicornis, Ixodes acutitarsus, Amblyomma javanense, and nymphs belonging to Haemaphysalis spp. PCR revealed that 13 (61.90%) and 8 (38.10%) bears harbored Hepatozoon ursi and Babesia DNA, respectively. Among the ticks examined, 157 (65.41%) and 128 (53.33%) samples were positive for H. ursi and Babesia, respectively. Conclusions To the best of our knowledge, this is the first study to establish a database of the hematological and plasma profiles of wild Formosan black bears and investigate ectoparasite infestation and Hepatozoon and Babesia spp. infection. In conclusion, these findings may serve as a reference for monitoring the health and population of locally endangered bears. Graphical Abstract

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Clinical and laboratory findings of Babesia infection in dogs

Cited by 25 publications

References 14 publications

Genetic Diversity of Canine Babesia Species Prevalent in Pet Dogs of Punjab, Pakistan

Genetic Diversity of Canine Babesia Species Prevalent in Pet Dogs of Punjab, Pakistan

Differences in serum protein electrophoretic pattern in dogs naturally infected with Babesia gibsoni and Babesia canis

Hematological and plasma profiles and ticks and tick-borne pathogens in wild Formosan black bears (Ursus thibetanus formosanus)

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