Clinical and laboratory findings in tick-borne encephalitis virus infection

Barp, Nicole; Trentini, Alessandro; Nuzzo, Mariachiara Di; Mondardini, Valeria; Francavilla, Ermenegildo; Contini, Carlo

doi:10.1016/j.parepi.2020.e00160

Cited by 20 publications

(34 citation statements)

References 30 publications

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“…Nonetheless, some patients with TBE have no (obvious) initial phase of the disease and present directly with central nervous system involvement. According to the reports consisting of 80 or more cases of TBE (presumably) caused by the European TBEV subtype, such a monophasic course is present in 13–44% of patients [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. In the present study, 283/705 patients (40.1%) had a monophasic course of the disease, which is a rather high proportion.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Clinical, Laboratory and Immune Characteristics of the Monophasic and Biphasic Course of Tick-Borne Encephalitis

et al. 2021

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The biphasic course of tick-borne encephalitis (TBE) is well described, but information on the monophasic course is limited. We assessed and compared the clinical presentation, laboratory findings, and immune responses in 705 adult TBE patients: 283 with monophasic and 422 with biphasic course. Patients with the monophasic course were significantly (p ≤ 0.002) older (57 vs. 50 years), more often vaccinated against TBE (7.4% vs. 0.9%), more often had comorbidities (52% vs. 37%), and were more often treated in the intensive care unit (12.4% vs. 5.2%). Multivariate logistic regression found strong association between the monophasic TBE course and previous TBE vaccination (OR = 18.45), presence of underlying illness (OR = 1.85), duration of neurologic involvement before cerebrospinal fluid (CSF) examination (OR = 1.39), and patients’ age (OR = 1.02). Furthermore, patients with monophasic TBE had higher CSF levels of immune mediators associated with innate and adaptive (Th1 and B-cell) immune responses, and they had more pronounced disruption of the blood–brain barrier. However, the long-term outcome 2–7 years after TBE was comparable. In summary, the monophasic course is a frequent and distinct presentation of TBE that is associated with more difficult disease course and higher levels of inflammatory mediators in CSF than the biphasic course; however, the long-term outcome is similar.

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Section: Discussionmentioning

confidence: 99%

Comparison of Clinical, Laboratory and Immune Characteristics of the Monophasic and Biphasic Course of Tick-Borne Encephalitis

et al. 2021

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“…In the endemic regions, approximately 10% of the childhood causes of encephalitis are incited by TBEV [8]. While the clinical symptoms of TBE are usually milder in children, the illness may also have more severe courses.…”

Section: Discussionmentioning

confidence: 99%

“…Symptoms are presented for 7-10 days with observed improvement after that time. Approximately one-third of those who initially had symptoms will evolve neurological symptoms [8]. The second phase, principally in children, can be characterized by an aseptic meningitis, or it may present as a meningoencephalitis form, poliomyelitic form with flaccid paralysis, or a polyradiculoneuritic form with a Guillain-Barré-like paralysis; all these forms tend to resolve spontaneously.…”

Section: State Of Knowledgementioning

confidence: 99%

“…The most frequent TBEV-linked neurological deficits may lead to disturbances in cognitive and motor function which often cause serious long-term disabilities. Following encephalitis, a lasting disability was also observed which may result from residual focal cerebral lesions or a postencephalitic state with cognitive and psychiatric symptoms [7,8]. Mild-to-moderate neurologic sequels or cognitive deficits affecting the child's learning and everyday activities have been described.…”

Section: Annals Of Agricultural and Environmental Medicinementioning

confidence: 99%

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Clinical course and neurological sequels after tick-borne encephalitis in children – case report

Pałyga-Bysiecka¹,

Krêcisz²,

Szczepańska³

2021

Ann Agric Environ Med.

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“…Many patients infected by TBEV remain asymptomatic. Symptomatic patients usually suffer from fever, headaches, body aches, malaise, nausea, and vomiting, with thrombocytopenia and leukopenia seen early in infection in humans, dogs and horses [ 114 , 115 , 116 , 117 , 118 , 119 , 120 ].…”

Section: Tick-borne Encephalitismentioning

confidence: 99%

The Impact of Tick-Borne Diseases on the Bone

Farooq

Moriarty

2021

Microorganisms

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Tick-borne infectious diseases can affect many tissues and organs including bone, one of the most multifunctional structures in the human body. There is a scarcity of data regarding the impact of tick-borne pathogens on bone. The aim of this review was to survey existing research literature on this topic. The search was performed using PubMed and Google Scholar search engines. From our search, we were able to find evidence of eight tick-borne diseases (Anaplasmosis, Ehrlichiosis, Babesiosis, Lyme disease, Bourbon virus disease, Colorado tick fever disease, Tick-borne encephalitis, and Crimean–Congo hemorrhagic fever) affecting the bone. Pathological bone effects most commonly associated with tick-borne infections were disruption of bone marrow function and bone loss. Most research to date on the effects of tick-borne pathogen infections on bone has been quite preliminary. Further investigation of this topic is warranted.

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Clinical and laboratory findings in tick-borne encephalitis virus infection

Cited by 20 publications

References 30 publications

Comparison of Clinical, Laboratory and Immune Characteristics of the Monophasic and Biphasic Course of Tick-Borne Encephalitis

Comparison of Clinical, Laboratory and Immune Characteristics of the Monophasic and Biphasic Course of Tick-Borne Encephalitis

Clinical course and neurological sequels after tick-borne encephalitis in children – case report

The Impact of Tick-Borne Diseases on the Bone

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