Clinical and laboratory features of COVID-19: Predictors of severe prognosis

Baştuğ, Aliye; Bodur, Hürrem; Erdoğan, Serpil; Gökçınar, Derya; Kazancıoğlu, Sümeyye; Kosovalı, Behiye Deniz; Özbay, Bahadır Orkun; Gök, Gamze; Turan, İşıl Özkoçak; Yılmaz, Gülsen; Gönen, Canan Çam; Yılmaz, Fatma Meriç

doi:10.1016/j.intimp.2020.106950

Cited by 120 publications

(125 citation statements)

References 23 publications

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“…Three studies were prospective [ 29 , 41 , 52 ], 51 retrospective [ 20 – 28 , 30 – 34 , 36 – 39 , 42 – 46 , 48 – 51 , 53 , 54 , 57 – 60 , 62 , 63 , 65 , 66 , 69 – 76 , 78 , 80 , 81 , 83 – 86 ], while 13 did not specifically declare the study design [ 23 , 35 , 40 , 47 , 55 , 56 , 61 , 64 , 67 , 68 , 77 , 79 , 82 ]. Fifty-two studies (77.6%) were performed in China [ 22 , 24 – 26 , 28 – 31 , 33 – 35 , 37 – 43 , 46 – 57 , 59 , 62 – 64 , 68 – 85 ] while the remaining 15 were conducted in the rest of the world [ 20 , 21 , 23 , 27 , 32 , 36 , 44 , 45 , 58 , 60 , 61 ...…”

Section: Resultsmentioning

confidence: 99%

“…Fifty-two studies (77.6%) were performed in China [ 22 , 24 – 26 , 28 – 31 , 33 – 35 , 37 – 43 , 46 – 57 , 59 , 62 – 64 , 68 – 85 ] while the remaining 15 were conducted in the rest of the world [ 20 , 21 , 23 , 27 , 32 , 36 , 44 , 45 , 58 , 60 , 61 , 65 – 67 , 86 ]. Endpoints included disease severity based on current clinical guidelines (31 studies, 46%) [ 22 , 24 , 28 , 32 , 33 , 35 , 36 , 38 , 39 , 44 – 47 , 49 – 52 , 54 , 56 , 58 , 64 , 66 , 69 , 72 , 73 , 75 , 77 , 79 , 81 – 83 ], survival (19 studies, 28%) [ 20 , 23 , 26 , 30 , 31 , 34 , 42 , 53 , 59 – 62 , 65 , …”

Section: Resultsmentioning

confidence: 99%

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Serum albumin concentrations are associated with disease severity and outcomes in coronavirus 19 disease (COVID-19): a systematic review and meta-analysis

et al. 2021

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Coronavirus disease 2019 (COVID-19), an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is responsible for the most threatening pandemic in modern history. The aim of this systematic review and meta-analysis was to investigate the associations between serum albumin concentrations and COVID-19 disease severity and adverse outcomes. A systematic literature search was conducted in PubMed, from inception to October 30, 2020. Sixty-seven studies in 19,760 COVID-19 patients (6141 with severe disease or poor outcome) were selected for analysis. Pooled results showed that serum albumin concentrations were significantly lower in patients with severe disease or poor outcome (standard mean difference, SMD: − 0.99 g/L; 95% CI, − 1.11 to − 0.88, p < 0.001). In multivariate meta-regression analysis, age (t = − 2.13, p = 0.043), publication geographic area (t = 2.16, p = 0.040), white blood cell count (t = − 2.77, p = 0.008) and C-reactive protein (t = − 2.43, p = 0.019) were significant contributors of between-study variance. Therefore, lower serum albumin concentrations are significantly associated with disease severity and adverse outcomes in COVID-19 patients. The assessment of serum albumin concentrations might assist with early risk stratification and selection of appropriate care pathways in this group.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Serum albumin concentrations are associated with disease severity and outcomes in coronavirus 19 disease (COVID-19): a systematic review and meta-analysis

et al. 2021

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“…The combination of NLR and MLR potentially helped to predict severe COVID-19 with an AUROC of 0.93 26 . In addition, SARS-CoV-2 causes an increase in inflammation, which leads to anemia owing to the destruction of RBCs and decreased erythrogenesis 26 , 27 . In contrast to these studies, no significant differences were noted between our groups with respect to RBC levels.…”

Section: Discussionmentioning

confidence: 99%

Identification of parameters in routine blood and coagulation tests related to the severity of COVID-19

Ding¹,

Yang²,

Huang³

et al. 2021

Int. J. Med. Sci.

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Objective: This study aimed to identify the predictive value of simple markers in routine blood and coagulation tests for the severity of coronavirus disease 2019 (COVID-19). Methods: A total of 311 consecutive COVID-19 patients, including 281 patients with mild/moderate COVID-19 and 30 patients with severe/life-threatening COVID-19, were retrospectively enrolled. Logistic modeling and ROC curve analyses were used to assess the indexes for identifying disease severity. Results: Lymphocyte and eosinophil counts of COVID-19 patients in the severe/life-threatening group were significantly lower than those of patients in the mild/moderate group (P < 0.001). Coagulation parameters, high-sensitivity C-reactive protein (hsCRP) levels and procalcitonin levels were higher in the severe/life-threatening group compared with the mild/moderate group (all P < 0.05). Univariate and multivariate logistic models revealed that hsCRP and fibrinogen degradation products (FDPs) were predictors of severe COVID-19 (OR = 1.072, P = 0.036; and OR = 1.831, P = 0.036, respectively). The AUROCs of hsCRP and FDP for predicting severe/life-threatening COVID-19 were 0.850 and 0.766, respectively. The optimal cutoffs of hsCRP and FDP for the severe/life-threatening type of COVID-19 were 22.41 mg/L and 0.95 µg/ml, respectively. Conclusion: Serum CRP and FDP levels are positively related to the severity of COVID-19. This finding indicates that CRP and FDP levels may potentially be used as early predictors for severe illness and help physicians triage numerous patients in a short time.

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“…Increased CRP levels may reflect diameter of lung lesion as well, as both variables have been shown to correlate positively [ 36 ]. Immunological parameters including higher leucocytes and reduced lymphocytes directly correlate with severity and worse prognosis in ICU patients [ 37 ]. Our study described lymphocyte/leucocyte ratio (14.4%) and leucocytes (8.9%) as major predictive factors of both ICU admission and mortality, thereby denoting the relevance of immunological markers in COVID-19 patients.…”

Section: Discussionmentioning

confidence: 99%

A Predictive Model and Risk Factors for Case Fatality of COVID-19

Álvarez‐Mon

Ortega

Gasulla

et al. 2021

JPM

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This study aimed to create an individualized analysis model of the risk of intensive care unit (ICU) admission or death for coronavirus disease 2019 (COVID-19) patients as a tool for the rapid clinical management of hospitalized patients in order to achieve a resilience of medical resources. This is an observational, analytical, retrospective cohort study with longitudinal follow-up. Data were collected from the medical records of 3489 patients diagnosed with COVID-19 using RT-qPCR in the period of highest community transmission recorded in Europe to date: February–June 2020. The study was carried out in in two health areas of hospital care in the Madrid region: the central area of the Madrid capital (Hospitales de Madrid del Grupo HM Hospitales (CH-HM), n = 1931) and the metropolitan area of Madrid (Hospital Universitario Príncipe de Asturias (MH-HUPA) n = 1558). By using a regression model, we observed how the different patient variables had unequal importance. Among all the analyzed variables, basal oxygen saturation was found to have the highest relative importance with a value of 20.3%, followed by age (17.7%), lymphocyte/leukocyte ratio (14.4%), CRP value (12.5%), comorbidities (12.5%), and leukocyte count (8.9%). Three levels of risk of ICU/death were established: low-risk level (<5%), medium-risk level (5–20%), and high-risk level (>20%). At the high-risk level, 13% needed ICU admission, 29% died, and 37% had an ICU–death outcome. This predictive model allowed us to individualize the risk for worse outcome for hospitalized patients affected by COVID-19.

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Clinical and laboratory features of COVID-19: Predictors of severe prognosis

Cited by 120 publications

References 23 publications

Serum albumin concentrations are associated with disease severity and outcomes in coronavirus 19 disease (COVID-19): a systematic review and meta-analysis

Serum albumin concentrations are associated with disease severity and outcomes in coronavirus 19 disease (COVID-19): a systematic review and meta-analysis

Identification of parameters in routine blood and coagulation tests related to the severity of COVID-19

A Predictive Model and Risk Factors for Case Fatality of COVID-19

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