Clinical and Laboratory Features of Human<i>Plasmodium knowlesi</i>Infection

Daneshvar, Cyrus; Davis, Timothy M. E.; Cox-Singh, Janet; Rafa'ee, Mohammad Z; Zakaria, Siti Khatijah; Divis, Paul Cliff Simon; Singh, Balbir

doi:10.1086/605439

Cited by 304 publications

(433 citation statements)

References 29 publications

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“…In Malaysian Borneo, the prevalence of mixed P. knowlesi-P. vivax infections appears to be low, with only one reported PCR-confirmed case in Sarawak (14) and 5/387 (1.3%) in our recent prospective study in Sabah (15). A separate study in Sabah reported 83 P. knowlesi-P. vivax mixed infections (35) but used earlier PCR primers that can include a false-positive P. vivax result for true P. knowlesi monoinfections (32).…”

Section: Discussionmentioning

confidence: 98%

“…In Malaysian Borneo, P. knowlesi is the most common cause of human malaria (10,11) and commonly causes severe disease, with fatal cases also reported (12)(13)(14)(15)(16). Early diagnosis of P. knowlesi infection is important; with its 24-h life cycle, it can rapidly cause high parasitemia and is three times as likely as P. falciparum to cause severe malaria (15).…”

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Combining Parasite Lactate Dehydrogenase-Based and Histidine-Rich Protein 2-Based Rapid Tests To Improve Specificity for Diagnosis of Malaria Due to Plasmodium knowlesi and Other Plasmodium Species in Sabah, Malaysia

et al. 2014

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g Plasmodium knowlesi causes severe and fatal malaria in Malaysia. Microscopic misdiagnosis is common and may delay appropriate treatment. P. knowlesi can cross-react with "species-specific" parasite lactate dehydrogenase (pLDH) monoclonal antibodies used in rapid diagnostic tests (RDTs) to detect P. falciparum and P. vivax. At one tertiary-care hospital and two district hospitals in Sabah, we prospectively evaluated two combination RDTs for malaria diagnosis by using both a pan-PlasmodiumpLDH (pan-pLDH)/P. falciparum-specific-pLDH (Pf-pLDH) RDT (OptiMAL-IT) and a non-P. falciparum VOM-pLDH/Pf-HRP2 RDT (CareStart). Differential cross-reactivity among these combinations was hypothesized to differentiate P. knowlesi from other Plasmodium monoinfections. Among 323 patients with PCR-confirmed P. knowlesi (n ‫؍‬ 193), P. falciparum (n ‫؍‬ 93), and P. vivax (n ‫؍‬ 37) monoinfections, the VOM-pLDH individual component had the highest sensitivity for nonsevere (35%; 95% confidence interval [CI], 27 to 43%) and severe (92%; CI, 81 to 100%) P. knowlesi malaria. CareStart demonstrated a P. knowlesi sensitivity of 42% (CI, 34 to 49%) and specificity of 74% (CI, 65 to 82%), a P. vivax sensitivity of 83% (CI, 66 to 93%) and specificity of 71% (CI, 65 to 76%), and a P. falciparum sensitivity of 97% (CI, 90 to 99%) and specificity of 99% (CI, 97 to 100%). OptiMAL-IT demonstrated a P. knowlesi sensitivity of 32% (CI, 25 to 39%) and specificity of 21% (CI, 15 to 29%), a P. vivax sensitivity of 60% (CI, 42 to 75%) and specificity of 97% (CI, 94 to 99%), and a P. falciparum sensitivity of 82% (CI, 72 to 89%) and specificity of 39% (CI, 33 to 46%). The combination of CareStart plus OptiMAL-IT for P. knowlesi using predefined criteria gave a sensitivity of 25% (CI, 19 to 32%) and specificity of 97% (CI, 92 to 99%). Combining two RDT combinations was highly specific for P. knowlesi malaria diagnosis; however, sensitivity was poor. The specificity of pLDH RDTs was decreased for P. vivax and P. falciparum because of P. knowlesi cross-reactivity and cautions against their use alone in areas where P. knowlesi malaria is endemic. Sensitive P. knowlesi-specific RDTs and/or alternative molecular diagnostic tools are needed in areas where P. knowlesi malaria is endemic.

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Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 99%

Combining Parasite Lactate Dehydrogenase-Based and Histidine-Rich Protein 2-Based Rapid Tests To Improve Specificity for Diagnosis of Malaria Due to Plasmodium knowlesi and Other Plasmodium Species in Sabah, Malaysia

et al. 2014

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“…Brevemente, la PCR1 se llevó a cabo en un volumen total de 50 µl de reacción conteniendo 1X de Buffer, 2 mM de MgCl 2 Los productos de PCR fueron sometidos a corrida electroforética en gel de agarosa al 2%, en buffer TAE 1X. El gel fue teñido en bromuro de etidio y visualizado en un transiluminador UV de la marca UVDI Major Science.…”

Section: Extracción Y Amplificación De Adnunclassified

“…La infección con P. ovale se ha reportado principalmente en África oriental con una prevalencia del 56%, también ha sido reportada en Bangladesh, India y países del sudeste Asiático como Vietnam, Filipinas, Indonesia, Papua Nueva Guinea, Camboya, Tailandia y Malasia (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12).…”

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Primer reporte de un caso importado de Malaria por Plasmodium ovale curtisi en Paraguay, confirmado por diagnóstico molecular

Puerto

Ozorio²,

Trinidad³

et al. 2015

Mem. Inst. Investig. Cienc. Salud

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“…The Plasmodium knowlesi parasite replicates and completes its blood stage cycle in 24 hour which leads to high parasite counts in a very short period of time, [4] which may result in massive erythrocyte destruction in patients [5] and complications such as respiratory distress, abnormal liver function including jaundice and renal failure [6]. Hunan infections of Plasmodium Knowlesi malaria has been recorded in some number of countries such as Malaysia, Thailand, China, Singapore, Philippines, Vietnam, Myanmar and Indonesian [4,7].…”

Section: Introductionmentioning

confidence: 99%

Backward bifurcation and optimal control of Plasmodium Knowlesi malaria

Abdullahi¹,

Hasan²,

Abdullah³

2014

AIP Conference Proceedings

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Abstract. A deterministic model for the transmission dynamics of Plasmodium Knowlesi malaria with direct transmission is developed. The model is analyzed using dynamical system techniques and it shows that the backward bifurcation occurs for some range of parameters. The model is extended to assess the impact of time dependent preventive (biological and chemical control) against the mosquitoes and vaccination for susceptible humans, while treatment for infected humans. The existence of optimal control is established analytically by the use of optimal control theory. Numerical simulations of the problem, suggest that applying the four control measure can effectively reduce if not eliminate the spread of Plasmodium Knowlesi in a community.

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Clinical and Laboratory Features of HumanPlasmodium knowlesiInfection

Abstract: Knowlesi malaria causes a wide spectrum of disease. Most cases are uncomplicated and respond promptly to treatment, but approximately 1 in 10 patients develop potentially fatal complications.

Cited by 304 publications

References 29 publications

Combining Parasite Lactate Dehydrogenase-Based and Histidine-Rich Protein 2-Based Rapid Tests To Improve Specificity for Diagnosis of Malaria Due to Plasmodium knowlesi and Other Plasmodium Species in Sabah, Malaysia

Combining Parasite Lactate Dehydrogenase-Based and Histidine-Rich Protein 2-Based Rapid Tests To Improve Specificity for Diagnosis of Malaria Due to Plasmodium knowlesi and Other Plasmodium Species in Sabah, Malaysia

Primer reporte de un caso importado de Malaria por Plasmodium ovale curtisi en Paraguay, confirmado por diagnóstico molecular

Backward bifurcation and optimal control of Plasmodium Knowlesi malaria

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