Clinical and laboratory features of murine typhus in central Tunisia: a report of seven cases

Létaief, A.; Kaabia, N.; Chakroun, M.; Khalifa, M.; Bouzouaïa, N; Jemni, L.

doi:10.1016/j.ijid.2004.09.011

Cited by 36 publications

(16 citation statements)

References 16 publications

(18 reference statements)

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“…16 Tunisia is also known to pose a risk for autochthonous murine typhus, although the disease is underdiagnosed or frequently misdiagnosed. 7 Others destinations have also been associated with murine typhus in travelers, including Mediterranean countries such as Crete, Spain, Italy, Cyprus, and Egypt. 13 For travelers in Southeast Asia, the countries of Thailand, Vietnam, Myanmar, Laos, India, and Nepal are also known to pose a risk.…”

Section: Discussionmentioning

confidence: 99%

“…The disease has, however, been documented as an emerging or reemerging diseases in several areas such as Hawaii, which had six cases per year before 2002 and 47 cases reported during 2002. 6 In Tunisia, Letaïef and others 7 published the first report of seven native cases of murine typhus in 2004, underlining an emergence of this probably underdiagnosed or misdiagnosed disease in that country. In Japan the first serologically diagnosed case of murine typhus was reported in 2004, showing the reemergence of this disease.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Murine Typhus in Returned Travelers: A Report of Thirty-Two Cases

Walter¹,

Botelho-Nevers²,

Socolovschi³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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Abstract. Murine typhus, caused by Rickettsia typhi and transmitted mainly by the rat fleas, Xenopsylla cheopis, has emerged in the field of travel medicine. We analyzed retrospectively the epidemiological, clinical, and biological characteristics of the 32 murine typhus cases that were diagnosed during the past 3 years at the World Health Organization Collaborative Center for Rickettsial diseases, Marseille, France. All of the cases occurred in travelers and most of them had returned from Africa (N = 13 of 32) and South-east Asia (N = 12 of 32). Exposure to rats was reported only in a few (N = 2 of 32) patients. Almost half of the cases were diagnosed in August and September. Only four patients presented the classic triad: fever, rash, and headache. Moreover, we report the first known cases of a hemophagocytic syndrome associated with this disease. Murine typhus must be considered as an etiologic agent of febrile illness in returning travelers, particularly in those with unspecific symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Murine Typhus in Returned Travelers: A Report of Thirty-Two Cases

Walter¹,

Botelho-Nevers²,

Socolovschi³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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show abstract

“…8,9 Investigation workup including serological test for syphilis, a chest x-ray, and tuberculin skin test was performed, all of which were within normal limits.…”

Section: Methodsmentioning

confidence: 99%

Visual Loss Associated with Rickettsial Disease

Kahloun

Gargouri

Abroug

et al. 2013

Ocular Immunology and Inflammation

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“…In humans, murine typhus often manifests as an acute febrile illness with a rash, 1,2 and protean clinical manifestations such as acute hepatitis, pneumonia, meningitis or in combination, have been reported in many countries. For example, aseptic meningitis is more common in the United States, 1 Thailand, 3 Tunisia, 4 Israel, 5 Spain, 6 and Greece, 7,8 and acute biochemical hepatitis is more common in Thailand and Laos. 9,10 Kidney involvement has been reported in Spain 11 and Israel.…”

Section: Introductionmentioning

confidence: 99%

Murine Typhus in Southern Taiwan during 1992–2009

Chang

Chen

Lee³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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Abstract. Clinical information regarding murine typhus in Taiwan is limited. In this study, 81 cases of serologically documented murine typhus during 1992-2009 at four referral hospitals in southern Taiwan were analyzed. There was a significant correlation between average environmental temperature and case numbers of murine typhus (r = 0.747, P = 0.005). Acute hepatitis was found in 67% of cases, and hyperbilirubinemia (serum total bilirubin 23.9 μmol/L) was found in 38%. The intervals between the initiation of appropriate therapy to defervescence were longer in patients with hyperbilirubinemia than those without hyperbilirubinemia (6.1 versus 4.1 days; P = 0.015). Nine (11.1%) showed development of severe illnesses such as acute respiratory distress syndrome (2 patients), aseptic meningitis (3), and acute renal failure (4). Only one died of acute respiratory distress syndrome. Cases of murine typhus were often found during the summer and had acute febrile hepatitis. Those patients with hyperbilirubinemia tended to have a delayed recovery even with appropriate therapy.

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Clinical and laboratory features of murine typhus in central Tunisia: a report of seven cases

Abstract: Murine typhus exists in Tunisia and its prevalence is underestimated. Further, more specific studies are needed to evaluate the true prevalence.

Cited by 36 publications

References 16 publications

Murine Typhus in Returned Travelers: A Report of Thirty-Two Cases

Murine Typhus in Returned Travelers: A Report of Thirty-Two Cases

Visual Loss Associated with Rickettsial Disease

Murine Typhus in Southern Taiwan during 1992–2009

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