Clinical and Laboratory Evaluation of a New Inhalation Agent: Compound 347 (CHF2-O-CF2-CHF Cl)

Effects of Enflurane on Haemodynamics and Oxygen Consumption in the Dog with Special Reference‐ to the Liver and Preportal Tissues

“…There is much disagreement as to the effect of enflurane on TPR. An increase in TPK following enflurane anaesthesia was found in man (DOBKIN et al 1968, HALDE-MANN et al 1975) and in the dog (THEYE & MICHENFELDER 1975, HORAN et al 1977, while T P R was reported to be unaffected in man by GRAVES & DOWNS (1974) and in the dog by KLIDE (1976) andMERIN et al (1976). Most studies showed, however, that enflurane lowered T P R in man (KARLICZEK et al 1974, LEVESQUE et al 1974, CALVERLEY et al 1975, SANTESSON et al 1978, in the monkey ( RITZMAN et al 1976), and in the dog (BEER et al 1973, PETER et al 1974, TARNOW et al 1974, which is in agreement with the findings in the present study.…”

“…The cardiovascular effects of enflurane have been extensively studied both in man and in experimental animals. Most studies in man have shown little impairment of cardiovascular function (DOBKIN et al 1968, HELRICH & CASCORBI 1969, SHIMOSATO & ETSTEN 1969, MARSHALL et al 1971, GRAVES & DOWNS 1974, LEVESQUE et al 1974, HALDEMANN et al 1975, while other studies have demonstrated a moderate (KARLICZEK et al , JORFELDT 1977 or marked (CALVERLEY et al 1975) cardiovascular depression. Surgical stimulation, however, reversed enflurane-induced circulatory de-pression (SANTESSON et al 1978).…”

Heart Rate Changes Caused by Enflurane and Halothane Anaesthesia in Man

“…(1974), but differs from the findings of both MARSHALL et al DOBKIN et al (1968). (1974), but differs from the findings of both MARSHALL et al DOBKIN et al (1968).…”

Central Blood Pooling as an Explanation for Lowered FRC during Anaesthesia? Thigh Volume Measurements by Plethysmography

“…The thigh bloodflow measurements indicated a 25% decrease in perfusion during inhalation and regional anaesthesia, findings which to some extent are at variance with results obtained during neurolept anaesthesia using the dyedilution technique (STJERNSTROM et al 1981). However, the presently measured fall in leg blood flow corresponds to the well-known fall in total cardiac output with general anaesthesia (DOBKIN et al 1968, EGEK et al 1970. A reduction of the inflow to the limb may diminish its blood volume, provided that venous outflow remains unaltered or less reduced than the inflow (a condition which, by nature, must be limited in time).…”