Clinical and laboratory characteristics of COVID-19 among adult patients admitted to the isolation centre at Abubakar Tafawa Balewa Teaching Hospital Bauchi, Northeast Nigeria

Jibrin, Yusuf Bara; Kenneth, Okon; Ibrahim, Maigari; Dunga, Jacob Amos; Ballah, Abubakar Muhammad; Umar, Mustapha Sabo; Mohammed, Aminu; Hassan, Zuwaira I

doi:10.11604/pamj.supp.2020.37.1.26162

Cited by 5 publications

(6 citation statements)

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“…Chronic medical conditions and comorbid diseases before admission for COVID-19 were not associated with increased low plasma level of potassium in this study (p>0.05) which contrast an earlier study in which chronic kidney diseases was significantly associated with low or higher plasma potassium [17]. In this study, an abnormal plasma potassium level during hospitalization was not associated with adverse patient outcomes.…”

Section: Discussioncontrasting

confidence: 96%

“…The risk of 30-day mortality during hospitalization was not significantly higher in hospitalized patients with COVID-19 who had plasma potassium value ≤3.5mmol/L. This study therefore did not support the belief that low plasma potassium unlike in other studies [17,18] significantly, and negatively impacts the outcome in patients with COVID-19.…”

Section: Discussioncontrasting

confidence: 72%

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Hypokalemia in Hospitalized COVID-19 Patients: Prevalence and Correlates

Ogunkoya

Bamidele²,

Uduagbamen³

et al. 2022

JAMMR

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Objectives: This study was designed to evaluate the prevalence, and the severity of hypokalemia, and the factors associated with hypokalemia among patients hospitalized with COVID-19. Methods: Random sampling technique was employed in this study. Socio-demographic data such as age, gender, weight (kg), height (meters) and BMI (kg/m 2 ) as well as presenting symptoms (pulmonary and extra-pulmonary), duration of admission, the need for mechanical ventilation and Original Research Articletreatment outcomes (discharged or died) as well as the plasma level of potassium (mmol/l) were extracted from the medical records of RT-PCR confirmed hospitalized cases of COVID-19 patients. Data collected were analyzed with IBM/ SPSS version 25.0 software. Discrete variables were presented as percentages and frequencies and the associations between qualitative variables tested using the Chi-square test at a level of significance of p < 0.05. Results: Hypokalaemia was detected in 61 out of 117 COVID-19 positive subjects used for this study during hospitalization. The mean serum potassium was 3.45±0.633 mmol/L. The majority of hypokalemic patients (n=35, 29.9%) patients experienced a mild decrease in serum potassium level (3-3.4 mmol/L). Risk factors for hypokalaemia were female sex and patients presenting with sneezing or/and sore throat. There was no relationship between the plasma potassium level and comorbid factors. There was no increasing trend of 30-day mortality associated with lower plasma potassium level. Conclusion: Plasma potassium levels should be monitored routinely and maintained within appropriate ranges in patients with COVID-19 especially in female patients as well as patient with significant upper respiratory symptoms such as sore throat and sneezing.

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Section: Discussioncontrasting

confidence: 96%

Section: Discussioncontrasting

confidence: 72%

Hypokalemia in Hospitalized COVID-19 Patients: Prevalence and Correlates

Ogunkoya

Bamidele²,

Uduagbamen³

et al. 2022

JAMMR

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“…In many studies, advanced age and male gender predominance and accompanying comorbidities such as DM, HT, CAD, and malignancy have been observed in patients with severe PCR (+) COVID-19 diagnosis. [10][11][12][13] Similar to the literature data, the patients followed in the intensive care unit were older and mostly male in our study and the mortality risk was statistically significantly higher, especially in those with a history of HT and malignancy. Hematological and biochemical parameters are of great importance in the evaluation of clinical picture of patients with COVID-19 diagnosis.…”

Section: Discussionsupporting

confidence: 88%

Clinical Importance of C-Reactive Protein to Albumin Ratio (Car) in Covid-19 Pneumonia

Hocanlı¹,

Kabak²

2022

Journal of Contemporary Medicine

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The course of COVID-19 infection due to SARS-CoV-2 is manifested by viral replication in the upper respiratory tract with or without lung involvement and extrapulmonary systemic hyperinflammation syndrome.Because it has a wide clinical spectrum ranging from asymptomatic cases to multiorgan failure, early identification of prognostic biomarkers is crucial to distinguish patients at risk of developing more serious disease. Our aim is to investigate the relationship between the C-reactive protein to albumin ratio (CAR), a biomarker which has both prognostic and diagnostic importance, and COVID-19 infection.

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“…So far, the literature from sub-Saharan Africa has been limited partly due to the impact of the pandemic on an already fragile healthcare system 12,13 . It is established that disease severity varies from asymptomatic to critical disease, which may require intensive care and may lead to mortality [14][15][16] . Older age and pre-existing co-morbidities such as chronic lung disease, hypertension, diabetes, and cardiovascular disease among others have been associated with more severe disease and increased mortality 7,16,17 .…”

Section: Introductionmentioning

confidence: 99%

“…, women presented to the hospital earlier than men (median [IQR], 3.0[1][2][3][4][5][6][7] days vs. 7.0[1][2][3][4][5][6][7][8][9][10][11][12][13][14] days, p<0.01). Also, male patients were more likely to have fever (62.8% vs. 44.1%, OR=2.4, 95% CI 1.1-4.1, p=0.02) and breathlessness (53.1% vs. 35.6%, OR=4.08, 95% CI 1.1-4.0, https://dx.doi.org/10.4314/mmj.v35i1.8 p=0.03), while diarrhoea was predominant among women (23.7% vs. 7.1%, OR=0.3, 95% CI 0.1-0.6 p<0.01).…”

mentioning

confidence: 99%

Demographic characteristics, clinical presentation and in-hospital outcome among patients with Covid-19 in a Nigerian tertiary hospital

et al. 2023

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BackgroundWe described the demographic/clinical characteristics and in-hospital outcome of patients with COVID-19 at the University of Nigeria Teaching Hospital (UNTH) during the first wave to inform evidence-based responses during subsequent waves in Africa. MethodologyWe conducted retrospective cohort analyses of adult patients ≥18 years with PCR or GeneXpert-confirmed SARS-CoV-2 infection. Data was extracted from patients’ medical records from 1st May to 30th September 2020. Based on disease severity, patients were either hospitalized (82) or managed at home (90). Logistic regression and cox-proportional hazard models were used to determine predictors of severe COVID-19 disease and in-hospital mortality, respectively. ResultsOf 172 cases, 113 (65.7%) were males, and the mean age was 45 ± 19 years. The majority were urban dwellers (72.1%), 19.8% had a positive history of contact with a confirmed/suspected case, 15.7% were healthcare workers while 68 (39.5%) had co-morbidities. Symptomatic patients comprised 73.3% of cases. Fever (p=0.02) and breathlessness (p=0.03) were commoner in males while diarrhoea (p<0.01) was predominant in females. On multivariate analysis, severe COVID-19 was predicted by the presence of co-morbidity (AOR= 14.44, 95% C.I= 4.79- 43.58, p <0.001)and prior antibiotic/antimalarial use (AOR= 6.35, 95% C.I= 2.24- 18.05, p =0.001) while being a non-healthcare worker (AOR= 0.18, 95% C.I= 0.04-0.78, p=0.02) was protective. However, none of the variables assessed predicted in-hospital mortality.Conclusion Our findings underscore the contributions of demographic variables in COVID-19 transmission and gender differences in clinical presentation. Underlying comorbidity likewise prior antimicrobial use increased the likelihood of severe COVID-19. The absence of mortality predictors in our study may be related to the relatively small number of deaths. Further studies are recommended to unravel the predominance of severe disease in healthcare workers.

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Clinical and laboratory characteristics of COVID-19 among adult patients admitted to the isolation centre at Abubakar Tafawa Balewa Teaching Hospital Bauchi, Northeast Nigeria

Cited by 5 publications

References 0 publications

Hypokalemia in Hospitalized COVID-19 Patients: Prevalence and Correlates

Hypokalemia in Hospitalized COVID-19 Patients: Prevalence and Correlates

Clinical Importance of C-Reactive Protein to Albumin Ratio (Car) in Covid-19 Pneumonia

Demographic characteristics, clinical presentation and in-hospital outcome among patients with Covid-19 in a Nigerian tertiary hospital

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