Clinical and Instrumental Objective Evidence of the Efficacy of a New Water-Based Nail-Strengthening Solution Containing Pistacia lentiscus and Hyaluronic Acid Applied for Up to 6 Months to Improve the Appearance of Weak, Brittle Nails

Abstract

Introduction: Brittle nails are fragile or split nails; they affect 20% of the population and may be primary or secondary to different conditions. The aim of our studies was to evaluate the efficacy and tolerability of a new waterbased nail-strengthening treatment containing hyaluronic acid and Pistacia lentiscus with daily application for a period of 1-3 months for one study (n = 30) and up to 6 months for a second study (n = 30). Methods: In total, we enrolled 60 patients of both sexes with brittle and weak nails due to primary or secondary causes and evaluated the Enhanced Digital Features To view enhanced digital features for this article go to

Application of a three‐dimensional scanner to the quantitative assessment of the nail plate condition after a hybrid manicure procedure—Preliminary study

“…The study of the nail apparatus in 3D space was conducted by Piraccini et al 16 . The study included 60 patients of both sex with brittle and weak nails due to primary or secondary causes.…”

“…The study of the nail apparatus in 3D space was conducted by Piraccini et al 16 The study included 60 patients of both sex with brittle and The applied 3D scanning technique made it possible to quantify the changes appearing after the manicure procedure. The differences in the height of the sections for the middle, proximal and distal portions of the nail show that the greatest changes concern the distal portions.…”

Impregnation of healthy nail tissue with optical clearing agents for improved optical coherence tomography imaging

“…The nail plate is formed by well‐differentiated keratinocytes that are called onychocytes, which derived from the cells of the keratogenous zone of the matrix 4,5 . On OCT images, the healthy nail plate appears as a layered structure containing horizontal homogeneous bands of varying intensity and thickness 1,6 . Generally, this band‐like structure presents three homogenous layers with a more signal‐intense layer in the middle (intermediate), showing a trilaminar aspect.…”

“…The nail plate acts as a hydrophilic membrane and is 1000 times more permeable to water than skin 7,8 . Consequently, drugs required to diffuse through the nail plate should normally have a high degree of water solubility, while topical ointments, creams, and greasy products show poor penetration and therapeutic effect 6 . The water content of healthy nails ranges between 10% and 30% and is directly related to relative humidity 9 but prolonged water immersion can raise their water content beyond physiological levels, causing the nail to swell 4,9 .…”

Lichen simplex chronicus of the scalp: dermoscopy and reflectance confocal microscopy features

“…Instrument and acquisition procedures have been described elsewhere. 4,5 Vertical VivaStack software imaging was used for the evaluation of adnexal structures from the ostium to the maximum depth. RCM images assessments were performed jointly on a highresolution monitor by two authors (V.D.M.…”