Clinical and immunological characterization of IgG subclass deficiency reveals that low levels of pneumococcal antibodies associate with need of immunoglobulin replacement therapy
Per Wågström,
Maria Hjorth,
Daniel Appelgren
et al.
Abstract:Immunoglobulin G subclass deficiencies (IgGsd) comprise a wide clinical spectrum from no symptoms to repeated respiratory infections and risk for the development of lung damage. In Sweden, immunoglobulin replacement therapy (IgRT) is considered in IgGsd patients with a high burden of infections. Our aims were to characterize immunological parameters in IgGsd on and off IgRT, and to identify factors that can predict the need of IgRT in IgGsd. Thirty-five patients with IgGsd were included in this prospective stu… Show more
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