Clinical and immunological characteristics of type 1 diabetes mellitus in a northwestern Colombian population

Tobón, Gabriel J.; Arango, Ana María Arboleda; Abad, Verónica; García, J. Luz Tovar; Cuervo, Héctor; Velásquez, Alejandro; Angel, Ivan D.; Vega, Patricia; Abad, Ángel; Anaya, Juan Manuel

doi:10.1016/j.diabres.2005.10.016

Cited by 13 publications

(7 citation statements)

References 29 publications

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“…Although CD may also be associated with T1D [26e28], this disease is extremely rare among our T1D patients [30]. However, most of the cases with CD may be subclinical or manifested at adulthood.…”

Section: Discussionmentioning

confidence: 99%

“…Cases were children with T1D all of whom fulfilled the diagnostic classification criteria proposed by the American Diabetes Association (ADA) [29] and who belonged to our T1D cohort [30]. Their information on demographics and cumulative clinical manifestations over the course of disease were obtained by both chart review and discussion with the patient and was collected in a standard data collection form.…”

Section: Demographics Of T1d Patients and Healthy Individualsmentioning

confidence: 99%

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Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus

Anaya

Castiblanco

Tobón

et al. 2006

Journal of Autoimmunity

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Section: Discussionmentioning

confidence: 99%

Section: Demographics Of T1d Patients and Healthy Individualsmentioning

confidence: 99%

Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus

Anaya

Castiblanco

Tobón

et al. 2006

Journal of Autoimmunity

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“…Their results were compared to those of FM who had no clinical diabetes, nor islet cell autoantibodies, and to those of healthy volunteers. Additional characteristics of this cohort, and results from epidemiological studies in this cohort have been described previously 11,12 …”

Section: Methodsmentioning

confidence: 99%

“…Additional characteristics of this cohort, and results from epidemiological studies in this cohort have been described previously. 11,12 Detection of Autoantibodies All samples were tested using the Bio-Rad BioPlex 2200 (Bio-Rad Laboratories, Hercules, California, USA). The BioPlex 2200 is a fully automated random-access analyzer built on a synthesis of multiplex, magnetic beads and flow cytometry technologies.…”

Section: Patientsmentioning

confidence: 99%

Anti‐infectious Antibodies and Autoimmune‐associated Autoantibodies in Patients with Type I Diabetes Mellitus and their Close Family Members

Krause

Anaya

Fraser

et al. 2009

Annals of the New York Academy of Sciences

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Type 1 diabetes mellitus (T1DM) is an autoimmune disease with complex interactions between genetic and environmental factors. We compared antibody levels to various infectious agents and of autoimmune-associated autoantibodies between Colombian T1DM patients, their close family members and healthy controls. Significantly lower levels of antibodies against several infectious agents were detected in the T1DM patients. These included Helicobacter pylori (P = 0.01), cytomegalovirus (P = 0.001), Epstein-Barr virus (P = 0.02) and Toxoplasma (P = 0.001). T1DM patients had significantly higher levels of IgG-anti-gliadin antibodies (P = 0.001) and IgG-antitissue transglutaminase antibodies (P = 0.03), and a borderline association with anticentromere antibodies (P = 0.06). The lower level of antibodies against infectious agents in T1DM patients may be related to their younger ages, but may also point to a protective role of those infections in T1DM development in susceptible individuals. Our results confirm the association between T1DM and celiac disease. A possible association with anticentromere antibody needs further studies.

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“…In T1D families, recruited cases were children all of whom fulfilled the diagnostic classification criteria proposed by the American Diabetes Association (ADA) [ 31 ] and had been previously described [ 32 ] ( Table 1 ). Their information on demographics and cumulative clinical manifestations over the course of disease were obtained by both chart review and discussion with the patient and were collected in a standard data collection form.…”

Section: Methodsmentioning

confidence: 99%

Familial Aggregation and Segregation Analysis in Families Presenting Autoimmunity, Polyautoimmunity, and Multiple Autoimmune Syndrome

Castiblanco

Sarmiento-Monroy

Mantilla

et al. 2015

Journal of Immunology Research

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Studies documenting increased risk of developing autoimmune diseases (ADs) have shown that these conditions share several immunogenetic mechanisms (i.e., the autoimmune tautology). This report explored familial aggregation and segregation of AD, polyautoimmunity, and multiple autoimmune syndrome (MAS) in 210 families. Familial aggregation was examined for first-degree relatives. Segregation analysis was implemented as in S.A.G.E. release 6.3. Data showed differences between late- and early-onset families regarding their age, age of onset, and sex. Familial aggregation of AD in late- and early-onset families was observed. For polyautoimmunity as a trait, only aggregation was observed between sibling pairs in late-onset families. No aggregation was observed for MAS. Segregation analyses for AD suggested major gene(s) with no clear discernible classical known Mendelian transmission in late-onset families, while for polyautoimmunity and MAS no model was implied. Data suggest that polyautoimmunity and MAS are not independent traits and that gender, age, and age of onset are interrelated factors influencing autoimmunity.

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Clinical and immunological characteristics of type 1 diabetes mellitus in a northwestern Colombian population

Cited by 13 publications

References 29 publications

Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus

Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus

Anti‐infectious Antibodies and Autoimmune‐associated Autoantibodies in Patients with Type I Diabetes Mellitus and their Close Family Members

Familial Aggregation and Segregation Analysis in Families Presenting Autoimmunity, Polyautoimmunity, and Multiple Autoimmune Syndrome

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