Clinical and Imaging Characteristics of Papillary Neoplasms of the Breast Associated with Malignancy: A Retrospective Cohort Study

Choi, Sang‐Hoon; Jo, Sang-Won; Kim, Dong-Hoon; Park, Jeong Seon; Choi, Y.L.; Kook, Shin Ho; Chung, Eun Chul; Lee, So‐Yeon

doi:10.1016/j.ultrasmedbio.2014.06.018

Cited by 11 publications

(11 citation statements)

References 21 publications

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“…In this study, we found patients with papillomas with high-risk or malignant lesions were older than those with benign papillomas, which was consistent with previous reports [28, 29]. Our study indicated that the risk of a papilloma with high-risk or malignant lesions in a patient being or older than 50 years was 4.506 times that equal to a patient younger than 50 years.…”

Section: Discussionsupporting

confidence: 92%

“…On MRI, 77.1% of papillomas presented as the mass in our study. We found that a mass size exceeding 10 mm was a risk indicator for a papilloma with high-risk or malignant lesions, consistent with previous studies [28, 29]. Tominaga et al [26] described four MRI types of benign papilloma as follows: oval nodule, irregular nodule, solid and cystic mass, and occult lesion.…”

Section: Discussionsupporting

confidence: 90%

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Magnetic resonance imaging features for differentiating breast papilloma with high-risk or malignant lesions from benign papilloma: a retrospective study on 158 patients

Wang

et al. 2018

World J Surg Onc

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BackgroundBenign breast papilloma is currently managed with conservative management with close observation. In contrast, papilloma with high-risk or malignant lesions warrants surgical excision. The purpose of our study was to investigate magnetic resonance imaging (MRI) features of breast papilloma and to identify imaging diagnostic indicators for papilloma with high-risk or malignant lesions.MethodsMRI features of 175 surgically confirmed papillomas on 158 patients were retrospectively reviewed. The 175 cases included 132 cases of benign papilloma and 43 cases of papilloma with high-risk or malignant lesions. The MRI features of these lesions were classified into three types: mass, non-mass enhancement (NME), and occult lesion. The occult lesion was defined as the presence of only ductal dilation without any enhanced lesions on MRI. For a mass lesion, the mixed mass-NME lesion was considered if linear, segmental or regional enhanced lesion was found adjacent to the mass. Clinical and MRI features were compared by univariate and multivariate analysis between the benign papilloma and the papilloma with high-risk or malignant lesions.ResultsMultivariate logistic regression analysis demonstrated that clinical characteristics including being or older than 50 years (odds ratio [OR] = 4.506), having bloody nipple discharge (OR = 4.499), and concurrent breast cancer (OR = 5.083) were significant indicators for papilloma with high-risk or malignant lesions. On MRI, most papillomas presented as mass (n = 135, 77.1%), and fewer as NME (n = 37, 21.1%) and occult lesion (n = 3, 1.7%). For the mass lesion, the logistic regression analysis demonstrated that a mass size exceeding 10 mm (OR = 2.956) and mixed mass-NME lesion (OR = 4.143) were independent risk indicators for a papilloma with high-risk or malignant lesions. For the NME lesion, the segmental or regional distribution was more commonly observed in the papilloma with high-risk or malignant lesions (61.5%) than the benign papilloma (12.5%) (P = 0.006). All the cases of occult lesions were benign papillomas.ConclusionsMRI features including a mass size exceeding 10 mm, mixed mass-NME lesion, and NMEs with segmental or regional distribution indicate a papilloma with high-risk or malignant lesions.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Magnetic resonance imaging features for differentiating breast papilloma with high-risk or malignant lesions from benign papilloma: a retrospective study on 158 patients

Wang

et al. 2018

World J Surg Onc

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“…The age analysis of the patients showed an average of 50.4 years; the mean in benign lesions (46 years) is lower and in malignant lesions (65 years) is higher, according to previous reviews [18][19][20][21] .…”

Section: Discussionmentioning

confidence: 65%

“…When the distance of the lesion from the nipple was analyzed, benign lesions were predominant in the central portion and malignant ones in the peripheral portion. These data were considered foreseeable in relation to previous studies [21][22][23] .…”

Section: Discussionmentioning

confidence: 81%

“…The Ki67 protein is absent in quiescent cells (G0) and is universally expressed in proliferating cells. These are advantages attributable to the possibility of distinguishing between the marker-able cell types, and thus, it is possible to differentiate a Ki67-producing inflammatory cell from a tumor cell, and because it is an inexpensive method, it can easily be included in the diagnostic routine 8,21 .…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of immunocytochemistry on the diagnosis of papillary mammary tumors by fine-needle aspiration biopsy

Mansani¹,

Bertucci²,

Netto³

et al. 2019

Mastology

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Este estudo observou a efetividade do método imunocitoquímico no diagnóstico das lesões papilares de mama a partir de amostras por punção aspirativa por agulha fina (PAAF), para validar o método que, aplicado à prática clínica, evitaria a exérese desnecessária dos pequenos papilomas intraductais da mama. Métodos: Foram analisados prontuários e exames de PAAF durante o período de 2003 a 2012 e posteriormente realizado exame imunocitoquímico com marcador de célula mioepitelial p63 e índice proliferativo Ki67, analisando-se especificidade e sensibilidade dos marcadores no diagnóstico de lesões papilares da mama. Resultados: A imunocitoquímica dos materiais das lesões papilares mamárias com os imunomarcadores Ki67 e p63 apresentou sensibilidade de 78,6% e especificidade de 73,33% na identificação das lesões benignas. Conclusões: O uso combinado desses marcadores em PAAF de lesão papilar mamária auxilia na orientação terapêutica da doença, mas novos estudos incluindo um maior número de casos devem ser realizados para melhor avaliar esse método.

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Diagnostic challenges in clinical, radiological and histopathological tests regarding papillomatous lesions of the breast

et al. 2018

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Clinical and Imaging Characteristics of Papillary Neoplasms of the Breast Associated with Malignancy: A Retrospective Cohort Study

Cited by 11 publications

References 21 publications

Magnetic resonance imaging features for differentiating breast papilloma with high-risk or malignant lesions from benign papilloma: a retrospective study on 158 patients

Magnetic resonance imaging features for differentiating breast papilloma with high-risk or malignant lesions from benign papilloma: a retrospective study on 158 patients

Evaluation of immunocytochemistry on the diagnosis of papillary mammary tumors by fine-needle aspiration biopsy

Diagnostic challenges in clinical, radiological and histopathological tests regarding papillomatous lesions of the breast

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