Clinical and histopathological staging in oral squamous cell carcinoma – Comparison of the prognostic significance

Kreppel, Matthias; Nazarli, Parvin; Grandoch, Andrea; Safi, Ali-Farid; Zirk, Matthias; Nickenig, Hans-Joachim; Scheer, Martin; Rothamel, Daniel; Hellmich, Martin; Zöller, Joachim E.

doi:10.1016/j.oraloncology.2016.07.004

Cited by 30 publications

(26 citation statements)

References 24 publications

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“…And there was tendency to associated with alcohol consumption (P=0.08). Our finding that the N classification predicts poor survival is reasonable, and is consistent with previous reports of the clinical significance of cervical lymph-node metastasis [14][15][16]. Our results also agree with many reports on the association between alcohol consumption and mortality and carcinogenesis, and with other reports indicating that alcohol is related to a poor prognosis [17][18][19][20][21][22].…”

Section: Discussionsupporting

confidence: 93%

Synaptic-Adhesion Molecules Neurexin 1 and Neuroligin 1 as Novel Prognostic Factors in Oral Squamous Cell Carcinoma

Hirohata¹,

Yanagawa²,

Takaoka³

et al. 2018

J Dents Dent Med

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Background: Synaptic adhesion molecules regulate synapse development and maintenance. Neurexins and neuroligins have been implicated in psychiatric disorders, and shown that they are related to vascular system and carcinomas in recent studies. In the present study we focused neurexin 1 and neuroligin1, and investigated the relationship between those two molecules expression and clinical features of oral cancer. Materials and methods: Fifty-six biopsy samples from oral squamous cell carcinomas (OSCCs) were analyzed semi quantitatively by immunohistochemistry. Correlations between the expression level of neurexin 1, neuroligin 1, p53, Ki67 and the clinical features of OSCCs were statistically analyzed. Results: The neurexin 1 expression group contained significantly advanced T (P < 0.05) and N classification positive cases (P < 0.01) by univariate analysis. Overall survival was compared with Kaplan-Meier analysis and the log rank statistic. The prognosis of neuroligin 1 expression group was significantly more favorable (P < 0.05). A Cox proportional hazards model was used to test the significance of survival time, and N classification positive (P < 0.05), neurexin 1 (P < 0.05) and neuroligin 1 (P < 0.01) were predictive factor for survival. Conclusions: Synaptic adhesive molecule could be useful prognosis factor for OSCC and may help to determine therapeutic policy.

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Section: Discussionsupporting

confidence: 93%

Synaptic-Adhesion Molecules Neurexin 1 and Neuroligin 1 as Novel Prognostic Factors in Oral Squamous Cell Carcinoma

Hirohata¹,

Yanagawa²,

Takaoka³

et al. 2018

J Dents Dent Med

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“…Among the significant prognostic factors in the present study, high clinical stage and poor tumor differentiation showed strong associations with risks of mortality among OSCC patients, which are traditional prognostic predictors and have been well-documented in many previous studies [ 16 ]. Cigarette smoking was found to be an independent predictor of survival in OSCC, which is consistent with other studies [ 11 ].…”

Section: Discussionsupporting

confidence: 68%

A novel prognostic index for oral squamous cell carcinoma patients with surgically treated

et al. 2017

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This study aims to develop an applicable prognostic index with conventional factors for predicting outcome of patients with oral squamous cell carcinoma (OSCC). We performed a prospective study in a large cohort of 892 OSCC patients in Fujian, China. All patients were randomly divided into a discovery group and validation group. A prognostic index was developed based on β value of each significant variable obtained from the multivariate Cox regression model. The results from discovery and validation set demonstrated thatthe model-4(included clinical stage, tumor differentiation, ill-fitting denture, oral hygiene and cigarette smoking) was the optimal model. The optimal cutoff points of prognostic index (1.88 and 2.80) were determined by X-tile program which categorized all subjects into low, middle and high risk subsets. Patients in high risk group were at the greatest risk of death compared with those in low risk group (HR: 6.02; 95%CI: 4.33-8.38). Moreover, there was a significant tendency of the worse overall survival with the higher prognostic index (Ptrend <0.001). The discriminatory capacity of prognostic index was 0.661(95%CI: 0.621-0.701). This study developed and validated a prognostic index that is an economical and useful tool for predicting the clinical outcomes of OSCC patients in Southeast China. Future randomized trials with larger cohort are required to confirm our results.

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“…In a multi‐center retrospective study about a disparity between clinical and pathological staging, the accuracy rate of clinical staging was relatively high; 78.1% in the early stage and 92.1% in the advanced stage tumors, while there was no significant difference of survivals between clinical and pathological staging . Recent study also showed that the concordance rate of two stagings was 62% for T and 59% for N classification with a higher prognostic value of pTNM than cTNM . In summary, most of previous works showed relatively low concordance rate between clinical and pathological stages without pretreatment functional imaging tools, which may cause a large diagnostic discrepancy between two staging systems.…”

Section: Discussionmentioning

confidence: 93%

“…16 Recent study also showed that the concordance rate of two stagings was 62% for T and 59% for N classification with a higher prognostic value of pTNM than cTNM. 19 In summary, most of previous works showed relatively low concordance rate between clinical and pathological stages without pretreatment functional imaging tools, which may cause a large diagnostic discrepancy between two staging systems.…”

Section: Discussionmentioning

confidence: 94%

“…Previous reports about the alteration of clinical and pathological staging did not include functional imaging (PET/CT) for initial workups of OCC, which might cause more differences between the two stagings. 16,17,19,20 A retrospective study of tongue cancer patients (N = 266) reported the concordance rate between clinical and pathological N classification was 43-79%. 17 Another multicenter prospective study including head and neck cancer patients (N = 560) revealed that the concordance rate of clinical and pathologic staging was 52% for T classification, 53.5% for N classification, and 54.9%…”

Section: Discussionmentioning

confidence: 99%

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Discrepancy between cTNM and pTNM staging of oral cavity cancers and its prognostic significance

Choi

Noh

Lee

et al. 2017

Journal of Surgical Oncology

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Clinical and histopathological staging in oral squamous cell carcinoma – Comparison of the prognostic significance

Cited by 30 publications

References 24 publications

Synaptic-Adhesion Molecules Neurexin 1 and Neuroligin 1 as Novel Prognostic Factors in Oral Squamous Cell Carcinoma

Synaptic-Adhesion Molecules Neurexin 1 and Neuroligin 1 as Novel Prognostic Factors in Oral Squamous Cell Carcinoma

A novel prognostic index for oral squamous cell carcinoma patients with surgically treated

Discrepancy between cTNM and pTNM staging of oral cavity cancers and its prognostic significance

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