Clinical and Histopathological Features of Folliculotropic Mycosis Fungoides: A Norwegian Patient Series

Mantaka, Panagiota; Helsing, Per; Gjersvik, Petter; Bassarova, Assia; Clausen, O. P. F.; Delabie, Jan

doi:10.2340/00015555-1476

Cited by 53 publications

(67 citation statements)

References 18 publications

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“…Some atypical forms of MF, such as folliculotropic MF, bullous MF and granulomatous MF, have been reported to show more aggressive behaviour than classical MF (8)(9)(10)(11)(12). In our case, the haematoma-like mass was associated with CD30* large-cell transformation.…”

Section: Discussionmentioning

confidence: 66%

A Case of Rapidly Progressive, Fatal Mycosis Fungoides Presenting as a Haematoma-like Lesion

Hattori¹,

Uchiyama²,

Tago³

et al. 2013

Acta Derm Venerol

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Mycosis fungoides usually follows an indolent clinical course. We report here a rapidly progressive case of mycosis fungoides with peculiar clinical and histological features, presenting as a haematoma-like mass on the thigh accompanied by multiple reddish brown erythematous lesions on the trunk and extremities. Histopathologically, the erythematous lesions showed epidermotropism of atypical T lymphocytes expressing CD4 and prominent syringotropism without syringometaplasia. The haematoma-like lesion consisted of diffuse and dense infiltrates of medium-to-large-sized pleomorphic lymphocytic cells expressing CD30, suggesting that CD30+ large-cell transformation had occurred. Mycosis fungoides presenting as a haematoma-like lesion is rare and may be a poor prognostic sign.

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Section: Discussionmentioning

confidence: 66%

A Case of Rapidly Progressive, Fatal Mycosis Fungoides Presenting as a Haematoma-like Lesion

Hattori¹,

Uchiyama²,

Tago³

et al. 2013

Acta Derm Venerol

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“…Da Pruritus ein Hauptsymptom der FMF ist, zeigte einer unserer Patienten dauerhafte generalisierte Exkoriationen [ 12 ] . Akneiforme FMF-Läsionen sind histologisch durch eine neoplastische Infi ltration der Zystenwand gekennzeichnet.…”

Section: Geschlecht/alter Stadium * Verwendete Behandlungen Effektivsunclassified

Underrecognized clinical features of folliculotropic mycosis fungoides: a large clinical series

Baykal

Atcı

Sarı

et al. 2017

J Deutsche Derma Gesell

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Hintergrund und Ziel: Als seltene Form der Mycosis fungoides (MF), ist die follikulotrope MF (FMF) durch ein breites Spektrum klinischer Symptome gekennzeichnet. Dazu gehören, neben den vorherrschenden follikulären Läsionen, auch viele atypische Manifestationen. Das Ziel der vorliegenden Studie war eine klinische Bewertung von FMF-Patienten, unter besonderer Berücksichtigung von vernachlässigten dermatologischen Merkmalen. Patienten und Methodik: Insgesamt wurden 27 FMF-Patienten aus dem 572 Patienten umfassenden MF-Register unserer Abteilung retrospektiv bezüglich ihrer Demographie sowie der klinischen Merkmale, Behandlungsformen, Nachsorge und Therapieergebnisse bewertet. Ergebnisse: Neben den bekannten klinischen Symptomen der FMF fanden wir Lichen-spinulosus-artige Läsionen mit begleitender Hypopigmentierung (n = 3) und Alopezie (n = 2), infiltrierte/erhabene, erythematöse Plaques im Gesicht, die zunächst als Lupus tumidus angesehen wurden (n = 2), pseudotumorale Läsionen, die klinisch eine MF im Tumorstadium vortäuschten (n = 1), dauerhafte Exkoriationen (n = 1), erythematöse, Rosazea-artige Papeln im Gesicht (n = 1) sowie kuppelförmige, asymptomatische, mit Muzin gefüllte (in der Histologie) Papeln/Knoten (n = 2), die andere krankheitsbedingte Läsionen überlagerten. Es kamen mehrere Therapieansätze mit unterschiedlichem Ergebnis zur Anwendung. Acht (29,6 %) Patienten hatten FMF im Spätstadium. Schlussfolgerungen: Das Bewusstsein für vernachlässigte klinische Symptome kann wesentlich dazu beitragen, verspätete Diagnosen dieser aggressiven MF-Variante zu verringern. SummaryBackground and Objective: A rare variant of mycosis fungoides (MF), folliculotropic MF (FMF) is characterized by a broad clinical spectrum that primarily includes follicle-based lesions but also many atypical clinical manifestations. The objective of the present study was to conduct a clinical analysis of patients with FMF, with a particular focus on highlighting underrecognized dermatological features.

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“…The pathology includes perivascular and periadnexal dermal T-cell infiltrates, with hyperchromatic and cerebriform nuclei, and sparing of the epidermis (folliculotropism instead of epidermotropism). Most cases show follicular mucinosis and cells are positive for cell surface markers in flow cytometry CD3+, CD4+, and CD8- [32,33]. Regarding treatment, it has recently been reported that psoralen plus UVA (systemic/bath) is effective [33], as well as combination with bexarotene or interferon [34,35].…”

Section: Cutaneous T-cell Lymphomamentioning

confidence: 96%

Alopecias Due to Drugs and Other Skin and Systemic Disorders

Guzmán-Sánchez¹,

Asz-Sigall²

2015

Alopecias - Practical Evaluation and Management

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In this chapter, we will discuss the most common alopecias due to drugs and other skin and systemic disorders. The following hair disorders will be analyzed: telogen effluvium (acute and chronic); anagen effluvium; folliculotropic mycosis fungoides; and folliculitis due to bacteria, fungi, parasites, human immunodeficiency virus disease, lupus erythematosus, and sarcoidosis. We will cover topics including the epidemiology, etiology, clinical picture, and diagnosis of and current treatments for each disease.

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Clinical and Histopathological Features of Folliculotropic Mycosis Fungoides: A Norwegian Patient Series

Cited by 53 publications

References 18 publications

A Case of Rapidly Progressive, Fatal Mycosis Fungoides Presenting as a Haematoma-like Lesion

A Case of Rapidly Progressive, Fatal Mycosis Fungoides Presenting as a Haematoma-like Lesion

Underrecognized clinical features of folliculotropic mycosis fungoides: a large clinical series

Alopecias Due to Drugs and Other Skin and Systemic Disorders

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