Clinical and histopathological characteristics of pityriasis alba

In, Sung Il; Yi, Sang‐Wook; Kang, Hee Young; Lee, Eun‐So; Sohn, Seonghyang; Kim, Y. C.

doi:10.1111/j.1365-2230.2008.03038.x

Cited by 42 publications

(28 citation statements)

References 12 publications

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“…Pityriasis alba has a distinctive clinical presentation as well histopathology. The lesions are typically found on the face of young children whereby the baseline histology is one exhibiting a low‐grade eczematous dermatitis without an obvious interface component . Other authors describe a variable reduction of melanin and melanocytes in the basal epidermis.…”

Section: Discussionmentioning

confidence: 99%

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Hypopigmented interface T‐cell dyscrasia: A form of cutaneous T‐cell dyscrasia distinct from hypopigmented mycosis fungoides

Magro

Hagen²,

Crowson

et al. 2014

The Journal of Dermatology

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Hypopigmentation in cutaneous T-cell lymphoproliferative disease should not always be equated with hypopigmented mycosis fungoides (MF). A form of hypopigmented pre-lymphomatous T-cell dyscrasia falling under the designation of the so-called hypopigmented interface variant of T-cell dyscrasia has recently been proposed. The aim of the present study was to establish hypopigmented interface T-cell dyscrasia as its own entity apart from other T-cell dyscrasias and MF using a patient case series. Twenty four cases of hypopigmented interface T-cell dyscrasia were identified in the dermatopathology database of Weill Medical College of Cornell University. There were 17 females and seven males (mean age, 36 years). In children and adolescents, the patients were most commonly of African American extraction. Truncal photo-protected areas manifesting as large solitary patches or multiple smaller macules were characteristic; disease progression to MF occurred in only one patient. The lesions responded to topical steroids and light therapy. The pathology was defined by a cell poor interface associated with degeneration of keratinocytes and melanocytes, and by lymphocytes whose nuclei showed low-grade cerebriform atypia, and which expressed a significant reduction in CD7 and CD62L expression. In 50% of the cases, the implicated cell type was of the CD8 subset. Clonality was not identified. Hypopigmented interface T-cell dyscrasia is a distinct entity separate from and rarely progressive to MF.

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Section: Discussionmentioning

confidence: 99%

“…Other authors describe a variable reduction of melanin and melanocytes in the basal epidermis. Ultrastructurally, degenerative changes in melanocytes and reduced number of melanosomes within keratinocytes were seen …”

Section: Discussionmentioning

confidence: 99%

Hypopigmented interface T‐cell dyscrasia: A form of cutaneous T‐cell dyscrasia distinct from hypopigmented mycosis fungoides

Magro

Hagen²,

Crowson

et al. 2014

The Journal of Dermatology

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“…Ultrastructurally, degenerative changes in melanocytes and reduced number of melanosomes within keratinocytes were seen. [32] Histopathological evaluation may be required to distinguish it from PV and leprosy.…”

Section: Pityriasis Albamentioning

confidence: 99%

Clinicopathological correlation of acquired hypopigmentary disorders

Patel¹,

Kubba²,

Kubba³

2013

Indian J Dermatol Venereol Leprol

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Acquired hypopigmentary disorders comprise a significant group of disorders that affect Indians and Asians. The pigment disturbance in darker skin individuals can be very distressing to the patient and the family. These disorders cover a wide array of pathologies including infections, autoimmune processes, lymphoproliferative disorders, and sclerosing diseases. Histological diagnosis is particularly important because treatments for these diseases are varied and specific. This review will focus on histopathological diagnosis based on clinicopathological correlation for commonly encountered disorders such as leprosy, vitiligo, lichen sclerosus, pityriasis alba (PA), and pityriasis versicolor (PV). Atypical or uncommon clinical presentation of classic diseases such as hypopigmented mycosis fungoides (HMF) and hypopigmented sarcoidosis are also included.

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“…Melanosomal transfer to keratinocytes was generally not disturbed. 24 Treatment with emollients and mild topical corticosteroids may accelerate the repigmentation in PA, but they have limited efficacy. Hyperkeratosis and parakeratosis were not consistently present, and it is unlikely that they play a significant role in the pathogenesis of the hypomelanosis.…”

Section: Discussionmentioning

confidence: 99%