Clinical and Histopathologic Features of Colorectal Adenocarcinoma in Crohn’s Disease

Galata, Christian; Hirsch, Daniela; Reindl, Wolfgang; Post, Stefan; Kienle, Peter; Boutros, Michael; Gaiser, Timo; Horisberger, Karoline

doi:10.1097/mcg.0000000000000817

Cited by 10 publications

(2 citation statements)

References 44 publications

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“…This observation agreement with previous findings [16,22]. Different pathogenetic mechanisms leading to CRC have been hypothesized in IBD [23]. Non-conventional dysplasia has been associated with low-grade tubuloglandular and mucinous adenocarcinomas in IBD [24].…”

Section: Discussionsupporting

confidence: 92%

Mucinous and Signet-Ring Cell Colonic Adenocarcinoma in Inflammatory Bowel Disease: A Case–Control Study

Neri

Mancone

Savino

et al. 2023

Cancers

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A higher frequency of mucinous and signet-ring cell colonic adenocarcinoma has been reported in inflammatory bowel disease (IBD). The primary aim was to investigate the frequency of mucinous and signet-ring cell colorectal adenocarcinoma in patients with IBD (Cases) versus age-matched non-IBD Controls. The secondary aims were to compare the characteristics of these two histotypes of colorectal cancer (CRC) in IBD patients vs. Controls and to search for specific risk factors in IBD. In a case–control study, all IBD patients with CRC diagnosed from 2000 to 2022 were enrolled and matched for age (1:2) with non-IBD Controls with CRC. The study population included 120 CRC patients (40 IBD, 80 Controls). In IBD, CRC included standard adenocarcinoma in 23 (57.5%) patients mucinous/signet-ring cell adenocarcinoma in 17 (42.5%) patients. The proportion of mucinous/signet-ring cell adenocarcinoma was higher in IBD than in Controls (17 [42.5%] vs. 18 [22.5%]; p = 0.03). In rectal CRC, the proportion of mucinous/signet-ring cell adenocarcinoma was higher than standard adenocarcinoma in IBD (8 [47.1%] vs. 4 [17.4%]; p = 0.04) but not in Controls (4 [22.2%] vs. 20 [32.2%]; p = 0.59). In rectal CRC, the proportion of these two histotypes was higher in Cases than in Controls (8/12 [66.6%] vs. 4/24 [16.6%]; p = 0.008), with no risk factors identified in IBD. CRC was more frequently represented by mucinous/signet-ring cell adenocarcinoma in IBD than in age-matched non-IBD Controls. In IBD, these two CRC histotypes were more frequent in the rectum.

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Section: Discussionsupporting

confidence: 92%

Mucinous and Signet-Ring Cell Colonic Adenocarcinoma in Inflammatory Bowel Disease: A Case–Control Study

Neri

Mancone

Savino

et al. 2023

Cancers

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“…A higher incidence of CD-RC has been observed in Asia compared with Western countries. However, we must raise awareness of the risk of CD-RC worldwide because several cases have been reported in Western countries ( 26 , 30 – 32 ).…”

Section: Discussionmentioning

confidence: 99%

Crohn's Disease–Associated Anorectal Cancer Has a Poor Prognosis With High Local Recurrence: A Subanalysis of the Nationwide Japanese Study

et al. 2023

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on behalf of the Study Group for Inflammatory Bowel Disease Associated Intestinal Cancers by the Japanese Society for Cancer of the Colon and Rectum INTRODUCTION: Colorectal cancer (CRC) is one of the major life-threatening complications in patients with Crohn's disease (CD). Previous studies of CD-associated CRC (CD-CRC) have involved only small numbers of patients, and no large series have been reported from Asia. The aim of this study was to clarify the prognosis and clinicopathological features of CD-CRC compared with sporadic CRC. METHODS:A large nationwide database was used to identify patients with CD-CRC (n 5 233) and sporadic CRC (n 5 129,783) over a 40-year period, from 1980 to 2020. Five-year overall survival (OS), recurrence-free survival (RFS), and clinicopathological characteristics were investigated. The prognosis of CD-CRC was further evaluated in groups divided by colon cancer and anorectal cancer (RC). Multivariable Cox regression analysis was used to adjust for confounding by unbalanced covariables.

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Morbus-Crohn-assoziierte kolorektale Karzinogenese

Hirsch

Gaiser

2018

Pathologe

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Clinical and Histopathologic Features of Colorectal Adenocarcinoma in Crohn’s Disease

Cited by 10 publications

References 44 publications

Mucinous and Signet-Ring Cell Colonic Adenocarcinoma in Inflammatory Bowel Disease: A Case–Control Study

Mucinous and Signet-Ring Cell Colonic Adenocarcinoma in Inflammatory Bowel Disease: A Case–Control Study

Crohn's Disease–Associated Anorectal Cancer Has a Poor Prognosis With High Local Recurrence: A Subanalysis of the Nationwide Japanese Study

Morbus-Crohn-assoziierte kolorektale Karzinogenese

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