Clinical and Histomorphometric Evaluation of Fresh Frozen Bone Allograft in Sinus Lift Surgery

Castilho, Tatiana Regina Ramos Nantes de; Tortamano, Pedro; Marotti, Juliana; Andrade, José Carlos S; Chilvarquer, Israel; Ximenez, Michel Eli Lipiec; Alves, Maria Teresa de Seixas

doi:10.1111/cid.12234

Cited by 6 publications

(4 citation statements)

References 22 publications

(47 reference statements)

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“…Besides, a study revealed that osteocyte lacunar volumes were unaffected by both age and sex [59]. In the current study the bone integrity index calculated as the ratio between osteocyte cells and osteocyte lacunae ( Figure 1D and Figure 3), as described by de Castilho [39], established osteocyte survival inside lacunae in exhumed bones. These findings are important because are related to bones inhumed between eight and twelve years in tropical soil.…”

Section: Fsi _2018supporting

confidence: 73%

See 1 more Smart Citation

The impact of burial period on compact bone microstructure: Histological analysis of matrix loss and cell integrity in human bones exhumed from tropical soil

Astolphi

Alves

Evison

et al. 2019

Forensic Science International

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Section: Fsi _2018supporting

confidence: 73%

“…Cell index was calculated as the ratio between total mean of osteocytes and osteocyte lacunae [39] in preserved areas, for each case. After scanning the HE-stained sections at a low magnification (100x), the areas of highest concentration of osteocytes in the bone were located and chosen as hot spots.…”

Section: Fsi _2018mentioning

confidence: 99%

The impact of burial period on compact bone microstructure: Histological analysis of matrix loss and cell integrity in human bones exhumed from tropical soil

Astolphi

Alves

Evison

et al. 2019

Forensic Science International

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show abstract

“…Reasons for excluding studies after full-text assessment were as follows: less than five patients included [46], less than five sinus augmentation procedures in each group [47], controlled clinical trials without randomization [48][49][50][51][52], MSFA in conjunction with additional augmentation procedures [53], alveolar ridge augmentation not involving MSFA [54], autogenous bone block graft was used as grafting material [55], histomorphometric outcome was not expressed in percentage [56], and MSFA was conducted with the use of space-maintaining mesh [57].…”

Section: Exclusion Of Studiesmentioning

confidence: 99%

Maxillary Sinus Floor Augmentation with Autogenous Bone Graft Alone Compared with Alternate Grafting Materials: a Systematic Review and Meta-Analysis Focusing on Histomorphometric Outcome

Starch‐Jensen¹,

Deluiz²,

Bruun³

et al. 2020

JOMR

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Objectives The objective of present systematic review was to test the hypothesis of no difference in histomorphometric outcome after maxillary sinus floor augmentation with autogenous bone graft alone compared with alternate grafting materials applying the lateral window technique. Material and Methods MEDLINE (PubMed), Embase and Cochrane library search in combination with hand-search of relevant journals were conducted. Human studies published in English until the 25 th of March, 2020 were included. Histomorphometric outcomes were evaluated by descriptive statistics and meta-analysis including 95% confidence interval (CI). Results Electronic search and hand-searching resulted in 1902 entries. Sixteen randomized controlled trials with unclear risk of bias fulfilled the inclusion criteria. Descriptive statistics showed comparable or improved histomorphometric outcomes with autogenous bone graft. Meta-analysis revealed a mean difference of -7.1% (CI = -11.0 to -3.2) indicating a significant higher amount of bone after maxillary sinus floor augmentation with autogenous bone graft compared with alternate grafting materials. Subgroup analysis demonstrated a non-significantly differences of -3.7% (CI = -10.9 to 3.4), -11.5% (CI = -25.9 to 2.8), 2.2% (CI = -16.9 to 21.3), and -4.6% (CI = -14.4 to 5.2), when autogenous bone graft was compared with allogeneic bone graft, xenograft, composite grafting materials involving xenograft or synthetic biomaterial mixed with autogenous bone graft, respectively. Conclusions Maxillary sinus floor augmentation with autogenous bone graft seems to facilitate improved histomorphometric outcomes compared with alternate grafting materials. However, the included studies were characterised by an unclear risk of bias and various methodological confounding factors. Hence, the conclusions drawn from the results of present study should be interpreted with caution.

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“…Allogeneic fresh frozen bone (FFB) has been widely used for years in orthopedic reconstructive surgery and reported to have different successful applications in the oral and maxillofacial district, including ridge augmentation [29][30][31][32], reconstruction of large post-traumatic or post-oncologic defects [33][34][35], and sinus floor elevation [36][37][38][39][40]. FFB is osteoconductive and weakly osteoinductive, and its main advantages compared to the autogenous bone are its unlimited availability coupled with the lower morbidity for the patient, with no necessity of second surgical site to harvest the graft.…”

Section: Discussionmentioning

confidence: 99%

Fresh Frozen Allogeneic Bone Block in Maxillary Sinus Floor Elevation: Histomorphometric Analysis of a Bone Specimen Retrieved 15 Years after Grafting Procedure

et al. 2019

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Nowadays implant-prosthetic rehabilitations are one of the best solutions for rehabilitating our patients. These allow obtaining rehabilitations with optimal functional and aesthetic performances. Often patients, who undergo implant-prosthetic therapy, have the conditions of edentulias, single or multiple, that have been going on for some time. This, according to the literature, produces resorption of the alveolar bone, a process that is complicated in the posterior area of the upper arch by a pneumatization of the maxillary sinuses. The loss of vertical height, so that the implant fixtures can be inserted, requires a maneuver called maxillary sinus floor elevation. This procedure, now safely performed with piezoelectric instruments, allows increasing bone height through bone grafting. In this study, the tissue obtained from a patient, after 15 years from the intervention, was evaluated by histological and SEM analyses. The bone healing in the patient has led to a perfect integration between the patient’s bone and the fresh frozen allograft used, however still present and detectable after 15 years.

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Clinical and Histomorphometric Evaluation of Fresh Frozen Bone Allograft in Sinus Lift Surgery

Abstract: FFB allograft was shown to be a feasible substitute for autogenous bone graft in sinus lift surgery.

Cited by 6 publications

References 22 publications

The impact of burial period on compact bone microstructure: Histological analysis of matrix loss and cell integrity in human bones exhumed from tropical soil

The impact of burial period on compact bone microstructure: Histological analysis of matrix loss and cell integrity in human bones exhumed from tropical soil

Maxillary Sinus Floor Augmentation with Autogenous Bone Graft Alone Compared with Alternate Grafting Materials: a Systematic Review and Meta-Analysis Focusing on Histomorphometric Outcome

Fresh Frozen Allogeneic Bone Block in Maxillary Sinus Floor Elevation: Histomorphometric Analysis of a Bone Specimen Retrieved 15 Years after Grafting Procedure

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