Clinical and Histological Features of Multiple Meningiomas Compared with Solitary Meningiomas

Huang, Hongyang; Buhl, Ralf; Hugo, Heinz-Hermann; Mehdorn, H. Maximilian

doi:10.1179/016164105x39932

Cited by 28 publications

(38 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are higher PR expression [11], and higher response rate (3/3) to anti-PR shown here. Tissue sample was available only for the patient 1, and demonstrated an extremely high PR expression.…”

Section: Discussionmentioning

confidence: 41%

“…Multiple meningiomas, defined as "at least two spatially separated meningiomas in a patient without signs of neurofibromatosis", are found in 1 % to 9 % of patients with meningioma according to series [11,19,21]. Compared to isolated meningiomas, multiple meningiomas have a higher female preponderance (90 %) and a stronger PR expression [11].…”

Section: Introductionmentioning

confidence: 98%

“…Compared to isolated meningiomas, multiple meningiomas have a higher female preponderance (90 %) and a stronger PR expression [11]. Whereas surgery and occasionally radiation therapy are the standard treatment for solitary meningioma, they are not suitable for meningiomatosis.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Successful treatment of multiple intracranial meningiomas with the antiprogesterone receptor agent mifepristone (RU486)

et al. 2014

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 41%

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Successful treatment of multiple intracranial meningiomas with the antiprogesterone receptor agent mifepristone (RU486)

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Multiple meningiomas occur in less than 10% of cases. 5 Most meningiomas are benign, corresponding to Grade I of the World Health Organisation (WHO) histopathologic classification 6 ; they are typically well circumscribed and slow growing. Atypical meningiomas (WHO grade II) comprise 5-7% of all cases; their pathological characteristics are an increased mitotic activity or three or more of the following features: increased cellularity; small cells with high nucleus: cytoplasm ratio; prominent nucleoli; uninterrupted pattern less or sheet-like growth; foci of spontaneous or geographic necrosis.…”

Section: Introductionmentioning

confidence: 99%

Meningioma recurrence: The efficacy and cost-effectiveness of current screening

Halliday

Fernandes

2010

British Journal of Neurosurgery

View full text Add to dashboard Cite

Scanning of post-operative meningioma patients to detect tumour recurrence is common practice. There are however no guidelines for how often this should be performed for meningiomas of differing Simpson Grades of surgical removal and World Health Organisation (WHO) histological grades. A literature search reveals no studies investigating its role in post-operative care. The objective of this study was to determine current post-operative scanning use, in particular its timing and frequency in relation to meningioma recurrence rate. We performed a retrospective analysis of the surgical records of patients that underwent meningioma excision between 1998 and 2003 in Addenbrookes Hospital, and their follow-up scans up to 9 years post-surgery. Age at surgery, Simpson grade of surgical removal, tumour location, WHO histological grade, post-surgical radiotherapy, dates of meningioma recurrences, and dates of post-operative CT and MRI scans up to present, were recorded for each patient. A total of 283 records were analysed. Using logistic regression we found that WHO grade and post-surgical radiotherapy were the strongest predictors of meningioma recurrence. We found that timing and frequency of scans between patients of the same stage and grade is highly variable. Data suggests that the role for regular short term post-operative scanning of WHO grade 1 meningioma patients, a group that form the bulk of meningioma patients, is limited, and should only be performed in select, clinically indicated cases. A time and cost analysis reveals that significant savings can be made by adopting this policy. Data from a greater number of patients with WHO grade 2 and 3 meningiomas needs to analysed before definite conclusions can be made about the regularity of post-operative scanning in these patients. Our audit study has revealed an opportunity for significant monetary and time savings to be made without any compromise of patient care.

show abstract

“…Of those, three were multiple meningiomas (23 %) [4,8,13]. Sporadic multiple meningiomas account for 9 % of all meningiomas [7]. Multiple meningiomas were initially reported to be related to the NF2 gene mutation with a clonal spread across the meninges [15], but might also correspond to mosaic NF2 cases [3,6,11].…”

mentioning

confidence: 98%

Multiple meningiomas in patients with Turner syndrome

et al. 2015

View full text Add to dashboard Cite

Dear Editor, We report two cases of multiple meningiomas in patients with Turner syndrome. Turner (Ullrich-Turner) syndrome is the most common diagnosed sex chromosome abnormality in females, affecting 1 in 2,000 live-born girls, and is characterized by complete or partial X chromosome monosomy [16]. A recent cohort study demonstrated an increased incidence of meningiomas in patients with Turner syndrome [14]. As girls diagnosed with Turner syndrome receive hormone replacement therapy and meningiomas are well-known hormone-related tumors, a possible role of hormones has been proposed to explain this association. These two cases add additional information on the relationships among Turner syndrome, hormone therapy and meningioma, stressing the possible roles of genetic and/or hormonal factors.In the first case, a 56-year-old female with a history of Turner syndrome was diagnosed with multiple meningiomas after a vaso-vagal episode: in the left pterional area (22.4 cm 3 ), in the right cerebellopontine angle (CPA) (2.95 cm 3 ) and at the floor of the middle cerebral fossa (0.8 cm 3 ). She had been under substitutive estrogen-progesterone hormonal therapy for 42 years. Three years later, the control MRI revealed a significant increase in size of the left pterional meningioma (21 %) associated with perilesional edema without associated symptoms. Subtotal resection of the left pterional meningioma was performed, while maintaining surveillance for the left CPA tumor in the absence of mass effect on the brainstem and the desire to preserved ipsilateral serviceable hearing. The final pathological diagnosis was grade I meningothelial meningioma, with a high expression of progesterone receptors. After a 9-year follow-up, the patient remained asymptomatic. MRI follow-up showed a slight increase of the APC meningioma (8.86 cm 3 ) and stability of the left temporal meningioma (1.83 cm 3 ) (Fig. 1, upper panel). In the second case, a 54-year-old patient with Turner syndrome was seen in our department for progressive right transmission deafness and tinnitus. The diagnosis magnetic resonance imaging (MRI) performed revealed multiple meningiomas: one right pterional, one left pterional and one parasagittal rolandic. As the patient was under estrogen therapy, hormonal substitution was stopped. On imaging follow-up the left pterional meningioma progressively increased in size with evidence of perilesional edema without clinical expression. This lesion was totally removed 4 years later because it had grown almost 40 % in volume, and no residual tumor was found on imaging. Microscopically, this was a WHO Grade I meningioma with a high expression of progesterone receptors. The two others meningiomas where stable on 7-year MRI follow-up (Fig. 1, lower panel).To date, 13 cases of meningiomas in patients with Turner syndrome have been published in the literature, including our cases. Of those, three were multiple meningiomas (23 %) [4,8,13]. Sporadic multiple meningiomas account for 9 % of all meningiomas [7]. Multiple meningiomas were ...

show abstract

Clinical and Histological Features of Multiple Meningiomas Compared with Solitary Meningiomas

Cited by 28 publications

References 28 publications

Successful treatment of multiple intracranial meningiomas with the antiprogesterone receptor agent mifepristone (RU486)

Successful treatment of multiple intracranial meningiomas with the antiprogesterone receptor agent mifepristone (RU486)

Meningioma recurrence: The efficacy and cost-effectiveness of current screening

Multiple meningiomas in patients with Turner syndrome

Contact Info

Product

Resources

About