Clinical and histological features of head and neck melanoma: a population-based study in France

Dabouz, F.; Barbe, Coralie; Lesage, C.; Clainche, A. Le; Arnoult, Guillaume; Hibon, E.; Bernard, Philippe; Grange, Florent

doi:10.1111/bjd.13489

Cited by 35 publications

(53 citation statements)

References 48 publications

(74 reference statements)

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“…Clinically, compared with melanoma of other skin sites, HNM, particularly scalp melanoma, is more aggressive and have an overall poorer prognosis, which may be partly explained by a late diagnosis due to hidden by hair . Our findings may also be partly attributed to the timely diagnosis among balding men compared with non‐balding men.…”

Section: Discussionmentioning

confidence: 64%

Male pattern baldness and risk of incident skin cancer in a cohort of men

Cho

Han

et al. 2016

Intl Journal of Cancer

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We examined the association between male-pattern baldness and risk of incident skin cancer, including invasive melanoma, invasive squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) in a prospective analysis, based on 36,032 participants from the Health Professionals’ Follow-up Study. In 1992, participants reported their status of male-pattern baldness at age 45 years by choosing from five crown-view pictograms based on Norwood’s classification. Diagnosis of skin cancers was reported biennially and information on melanoma and SCC was pathologically confirmed. We identified 327 melanoma cases, 1324 SCC cases, and 8438 BCC cases during the follow-up. Male-pattern baldness was not significantly associated with risk of incident melanoma, but was significantly associated with increased risk of SCC and BCC. The multivariate-adjusted hazard ratio (HR) (95% confidence interval, CI) for the highest category of baldness (frontal plus severe vertex baldness) was 1.33 (1.06–1.68) for SCC (Ptrend=0.001) and 1.23 (1.12–1.35) for BCC(Ptrend<0.0001), compared with no baldness. Analyses by body sites found significant associations between frontal plus moderate to severe vertex baldness and risk of melanoma (HR=1.83, 95% CI: 1.01–3.34) and SCC (HR=1.30, 95% CI: 1.02–1.66) at head and neck. The associations were particularly stronger for scalp melanoma (HR=7.15, 95% CI: 1.29–39.42) and scalp SCC (HR=7.09, 95% CI: 3.84–13.08), but not for non-scalp head and neck sites. Information on body sites was not available for BCC. In conclusion, male pattern baldness may be associated with increased risk of skin cancer, but the associations may only exist for those occurring at head and neck, particularly at scalp.

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Section: Discussionmentioning

confidence: 64%

Male pattern baldness and risk of incident skin cancer in a cohort of men

Cho

Han

et al. 2016

Intl Journal of Cancer

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“…In general, trunk melanomas are more common in younger patients and head and neck melanomas occur in older patients(Dabouz et al, ). Long‐term UV exposure may lead to DNA damage over time that perpetuates development of different histologic subtypes (i.e., Lentigo Maligna Melanoma, LMM; Dabouz et al, ; Gillgren et al, ; Thorn, Adami, Ringborg, Bergstrom, & Krusemo, ). We found that trunk and extremity melanomas were associated with decreased melanoma‐specific mortality in the older age‐group in the multivariable analysis ( p ‐value = 0.007 for trunk and p ‐value = 0.05 for extremities) (Table ).…”

Section: Resultsmentioning

confidence: 99%

Histopathologic variables differentially affect melanoma survival by age at diagnosis

Mishra

Barnhill

Paddock

et al. 2019

Pigment Cell Melanoma Res

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We evaluated clinical, phenotypic, behavioral, and histopathologic variables in relationship to melanoma‐specific survival by age at diagnosis among 650 population‐based melanoma patients in Connecticut, with 20 years of follow‐up. Only one variable, skin awareness, was significantly associated with melanoma mortality in both groups. The variables that differed between the age‐groups were anatomic site, Breslow thickness, histologic subtype, mitoses, tumor‐infiltrating lymphocytes (TILs), and solar elastosis. Head and neck melanoma, Breslow thickness, nodular melanoma, and solar elastosis were all significantly more likely to be associated with mortality among the older subjects; among the younger subjects, the presence of mitoses was associated with an increased probability of dying and TILs were associated with a reduced risk of mortality.

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“…Indeed, case 2 in our study was initially diagnosed as nodular melanoma. The nodular subtype of melanoma appears to be overrepresented among the melanomas arising in the head and neck (20% vs. 12% at other sites) . Nodular melanomas may lack a radial growth phase and show a nested growth pattern, like clear cell sarcoma.…”

Section: Discussionmentioning

confidence: 99%

“…The nodular subtype of melanoma appears to be overrepresented among the melanomas arising in the head and neck (20% vs. 12% at other sites). 18 Nodular melanomas may lack a radial growth phase and show a nested growth pattern, like clear cell sarcoma. In addition, melanomas with clear cell morphology are described, which may add to diagnostic confusion.…”

Section: Discussionmentioning

confidence: 99%

Primary clear cell sarcoma of the head and neck: a case series with review of the literature

et al. 2016

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Clinical and histological features of head and neck melanoma: a population-based study in France

Abstract: HNMs highly differ from MOS, and are clinically and histologically heterogeneous, possibly as a consequence of different patterns of sun exposure. These data could help to improve primary and secondary prevention messages for patients and doctors.

Cited by 35 publications

References 48 publications

Male pattern baldness and risk of incident skin cancer in a cohort of men

Male pattern baldness and risk of incident skin cancer in a cohort of men

Histopathologic variables differentially affect melanoma survival by age at diagnosis

Primary clear cell sarcoma of the head and neck: a case series with review of the literature

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