Clinical and histological features in pediatric and adolescent/young adult patients with renal disease: a cross-sectional analysis of the Japan Renal Biopsy Registry (J-RBR)

Sato, Hiroshi; Shimizu, Akira; Sugiyama, Hitoshi; Matsuoka, Katsuyoshi; Konomoto, Takao; Hasebe, Naoyuki; Nakagawa, Naoki; Shibazaki, Sekiya; Miyamoto, T; Ito, Masanori; Nishio, Saori; Nakazawa, Daigo; Okamoto, Takayuki; Sato, Yasuyuki; Suzuki, Akira; Moniwa, Norihito; Tanaka, Marenao; Fukasawa, Yuichiro; Takizawa, Hideki; Soma, Jun; Nakaya, Izaya; Kazama, Junichiro James; Tanaka, K.; Tanaka, Mizuko; Sato, Toshinobu; Sanada, Satoshi; Hashimoto, Hajime; Miyazaki, Mariko; Nagasawa, Tasuku; Okamoto, Koji; Konta, Tsuneo; Ichikawa, Kazunobu; Ogino, Daisuke; Kitamura, Hiroshi; Imasawa, Toshiyuki; Matsumura, Chieko; Akutsu, Naotake; Kamura, Koichi; Takeda, Takeshi; Ishimitsu, Toshihiko; Hiromura, Keiju; Kaneko, Yoriaki; Ikeuchi, Hidekazu; Sakairi, Toru; Nagata, Daisuke; Saito, Osamu; Akimoto, Tetsu; Maeshima, Akito; Yokoo, Takashi; Tsuboi, Nobuyuki; Koike, Kentaro; Tanno, Yudo; Yokote, Shinya; Miyazaki, Yoichi; Ueda, Hiroyuki; Okabe, Masahiro; Tanaka, Mai; Ikeda, Masato; Shimizu, Akihiro; Suzuki, Yusuke; Goda, Tomohito; Kihara, Masao; Takagi, Miyuki; Ishikawa, Masahiro; Kaname, Shinya; Karube, Miho; Fukuoka, Kazuhito; Kondo, Takahisa; Ebihara, Itaru; Sato, Chihiro; Sakai, Yukinao; Hirama, Akio; Mii, Akiko; Fuke, Yoshinobu; Abe, Masanori; Okada, Hirokazu; Inoue, Tsutomu; Iwashita, Takatsugu; Kogure, Yuta; Kanozawa, Koichi; Hasegawa, Hajime; Ubukata, Masamitsu; Shibata, Takanori; Inoue, Yoshio; Suzuki, Tomo; Ichikawa, Daisuke; Shirai, Sayuri; Shibagaki, Yugo; Wada, Takehiko; Fukagawa, Masafumi; Fujigaki, Yoshihide; Horie, Shigeo; Muto, Satoru; Kobayashi, Masaki; Hirayama, Kouichi; Shimohata, Homare; Hamada, Riku; Hataya, Hiroshi; Hattori, Motoshi; Miura, Kenichiro; Ishizuka, Kiyonobu; Kaneko, Naoto; Nitta, Kosaku; Uchida, Keiko; Moriyama, Takahito; Ubara, Yoshifumi; Suwabe, Tatsuya; Hoshino, Junichi; Hayami, Noriko; Nangaku, Masaomi; Tanaka, Tetsuhiro; Hamasaki, Yoshifumi; Honda, Kenjiro; Harita, Yutaka; Kanda, Shoichiro; Kajiho, Yuko; Yamagata, Kunihiro; Usui, Joichi; Kawamura, Tetsuya; Tamura, Kouichi; Wakui, Hiromichi; Kanaoka, Tomohiko; Kobayashi, Ryu; Hirawa, Nobuhito; Saka, Sanae; Fujiwara, Akira; Narita, Ichiei; Goto, Shin; Itoh, Yumi; Imai, Naofumi; Kamijo, Yuji; Hashimoto, Koji; Yamaguchi, Akinori; Sonoda, Kosuke; Takahashi, Kazuya; Furuya, Fumihiko; Kitagawa, Kiyoki; Yokoyama, Hitoshi; Fujimoto, Keiji; Hayashi, Norifumi; Koya, Daisuke; Kitada, Munehiro; Kuroshima, Yuka; Wada, Takashi; Furuichi, Kengo; Shimizu, Miho; Sakai, Norihiko; Katou, Yasuhiro; Yamamura, Yuta; Koshino, Yoshitaka; Takaeda, Chikako; Yoshida, Haruyoshi; Horiguchi, Takayasu; Shinozaki, Yukiko; Kurabayashi, Masahiko; Ota, Satoshi; Ishida, Yoh-ichi; Iwano, Masayuki; Takahashi, Naoki; Kasuno, Kenji; Mikami, Daisuke; Yamazaki, Hidenori; Fujita, Naoya; Hibino, Satoshi; Tanaka, Kazuki; Ito, Yasuhiko; Nagai, Takuhito; Kuriyama, Takayuki; Nobata, Hironobu; Kimura, Shogo; Soga, Yuka; Sakakima, Masanori; Yuzawa, Yukio; Tsuboi, Naotake; Hayashi, Hiroki; Takahashi, Kazuo; Yasuda, Hideo; Ohashi, Naro; Sato, Taichi; Takeda, Asami; Otsuka, Yasuhiro; Ono, Minamo; Tomonari, Tatsuya; Fukuda, Michio; Mizuno, Masashi; Suzuki, Taisei; Kominato, Satoru; Kasuga, Hirotake; Maruyama, Shoichi; Yasuda, Yoshinari; Kosugi, Tomoki; Ishimoto, Takuji; Mori, Noriko; Tanaka, Satoshi; Murata, Tetsuya; Fujimoto, Mika; Katayama, Kan; Hazu, Yokkaichi; Mizutani, Yasuhide; Kodera, Hitoshi; Miyake, Masato; Oka, Kunihiro; Kajiwara, Nobuyuki; Tsukamoto, Tatsuo; Endo, Tokiko; Muso, Eri; Nishi, Shinichi; Goto, Shunsuke; Iijima, Kazumoto; Nozu, Kandai; Yamamura, Takehira; Adachi, Yoko; Nishihara, Takaaki; Kamezaki, Michitsugu; Seta, Koichi; Yahata, Kensei; Tamagaki, Keiichi; Kusaba, Tetsuro; Shiotsu, Yayoi; Yanagita, Motoko; Yokoi, Hideki; Sakai, Kaoru; Ishii, Akira; Tsuruya, Kazuhiko; Samejima, Ken-ichi; Yoshihara, Fumiki; Mori, Katsuhito; Tsuda, Akihiro; Nakatani, Shinya; Konishi, Yoshio; Morikawa, Takashi; Kitabayashi, Chizuko; Fujimaru, Rika; Hayashi, Terumasa; Tanaka, Shōji; Yamamoto, Katsusuke; Ashida, Akira; Sugawara, Akira; Koshikawa, Masao; Ogawa, Yoshihisa; Kawanishi, Tomoko; Yamauchi, Atsushi; Nagatoya, Katsuyuki; Mori, Daisuke; Haga, Ryota; Isaka, Yoshitaka; Yamamoto, Ryohei; Namba, Tomoko; Nishio, Takeshi; Araki, Shin‐ichi; Shoji, Shigeichi; Yamakawa, Kenjiro; Okuno, Senji; Fukunaga, Masao; Shima, Yuko; Hama, Taketsugu; Sügimura, Takashi; Ohya, Masaki; Kashihara, Naoki; Asano, Kenichiro; Kanzaki, Motoko; Fukuoka, Kosuke; Takao, Masaki; Doi, Shigehiro; Nakashima, Ayumu; Doi, Toshiki; Yamazaki, Kan; Sugiyama, Nobuyoshi; Inaba, Yuichiro; Ozeki, Kouji; Hiramatsu, Masayuki; Maruyama, Kouichi; Momoki, Noriya; Morinaga, Hiroshi; Akiyama, Ayu; Uchiyama, Natsumi; Nishiwaki, Mariko; Imai, Tsuyoshi; Ito, Takafumi; Egawa, Masahiro; Fukunaga, Shohei; Okada, Shinichi; Kitamoto, Koichi; Yokoyama, Hiroyuki; Yamada, Yuko; Sofue, Tadashi; Minamino, Tetsuo; Ibuki, Emi; Terada, Yoshio; Horino, Taro; Shimamura, Yuto; Matsumoto, Tatsuki; Fujieda, Mikiya; Imamura, Masayuki; Kubo, Shoji; Urushihara, Maki; Kinoshita, Yukiko; Abe, Hideharu; Nagai, Kojiro; Masutani, Kosuke; Yasuno, Tetsuhiko; Ito, Kenji; Hatae, Ken; Nishimura, Manao; Maruyama, Hiroyo; Matsumoto, Koji; Mukoyama, Masashi; Adachi, Masataka; Fukami, Kei; Yano, Junko; Nakano, Toshiaki; Tsuchimoto, Akihiro; Yamada, S.; Matsukuma, Yuta; Kiyohara, Yutaka; Ninomiya, Toshiharu; Nagata, Michio; Yokota-Ikeda, Naoko; Kodama, Keiko; Taguchi, Takashi; Nishino, Tomoya; Obata, Yoko; Uramatsu, Tadashi; Katafuchi, Ritsuko; Nakayama, Masaru; Yasumori, Ryokichi; Miyazono, Motoaki; Nonaka, Eriko; Rikitake, Shuichi; Fukuda, Makoto; Higashi, Harumichi; Fujimoto, Shouichi; Sato, Yuji; Kikuchi, Masao; Minakawa, Akihiro; Tamura, Masahito; Miyamoto, Tetsu; Ohya, Yusuke; Kohagura, Kentaro

doi:10.1007/s10157-021-02077-w

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…Data from other regions showed that IgAN accounted for more than 25% of kidney biopsies from Japanese children [ 3 ] and 20% of European children with biopsy-proven glomerular diseases [ 4 , 5 ]. IgAVN is still the most prevalent cause of secondary glomerulonephritis, including lupus nephritis and HBV infection-related glomerulonephritis, as it is detected in nearly 20% of Japanese children [ 3 ] and 11.6% of Italian children [ 26 ]. A lower proportion of IgAN or IgAVN was found in biopsies from Chinese children (see Supplementary Tables 1 and 2 ); this might be attributed to ethnic disparities or indications of biopsy.…”

Section: Epidemiology Of Igan and Igavn In Chinese Childrenmentioning

confidence: 99%

“…It has been reported in 11.2% and 51.2% of kidney biopsies in Chinese children, by studies of 33 hospitals and national hospitalization data, respectively [ 1 , 2 ]. Additionally, it has been detected in more than 25% of kidney biopsies from Japanese children [ 3 ] and in 20% of European children with biopsy-proven glomerular diseases [ 4 , 5 ]. IgAN is defined as the predominant deposition of IgA in the glomerulus, as determined by immunofluorescence staining.…”

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Diagnosis and treatment of IgA nephropathy and IgA vasculitis nephritis in Chinese children

Zhong

Ding

2022

Pediatr Nephrol

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IgA nephropathy (IgAN) and IgA vasculitis-associated nephritis (IgAVN) are among the most frequent childhood glomerular diseases and are characterized by significant variability in clinical manifestations, pathological presentation and long-term outcomes. IgAVN, alternatively called purpura nephritis, is pathologically indistinguishable from kidney-limited IgAN. In Chinese children, the clinical presentations and pathological manifestations of IgAN and IgAVN are variable. The severity of proteinuria and abnormalities in kidney function and blood pressure of children in China are comparable to those of children in Europe, the USA, and Japan. Compared to Caucasian children and Japanese children, crescents were more common in Chinese children with IgAN or IgAVN. Approximately 10–20% of childhood IgAN or IgAVN progresses to impaired kidney function in China. Since 2007, a series of guidelines on the diagnosis and treatment of pediatric kidney diseases has been published following the principles of evidence-based medicine. However, a large difference exists between the Chinese evidence-based guidelines and the guidelines developed by Kidney Disease: Improving Global Outcomes (KDIGO) in 2021. Chinese children with IgAN or IgAVN were more likely to be treated with steroids or immunosuppressive agents. Further studies exploring the optimal treatment regimen for childhood IgAN or IgAVN are needed in the future.

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Section: Epidemiology Of Igan and Igavn In Chinese Childrenmentioning

confidence: 99%

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confidence: 99%

Diagnosis and treatment of IgA nephropathy and IgA vasculitis nephritis in Chinese children

Zhong

Ding

2022

Pediatr Nephrol

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Renal pathology in adult and paediatric population of Japan: review of the Japan renal biopsy registry database from 2007 to 2017

Goto,

Imaizumi,

Hamada

et al. 2023

J Nephrol

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Background The Japan Renal Biopsy Registry (J-RBR), a nationwide, web-based, registry system, started in 2007. This study aimed to summarise the epidemiology of biopsy-diagnosed kidney disease in Japan over 10 years. Methods We analysed the J-RBR database, from 2007 to 2017. Patients’ clinical data collected at the time of biopsy and histopathological diagnoses were used for epidemiological and clinicopathologic analyses. Results The predominant renal biopsy diagnoses were immunoglobulin A nephropathy (39.2%), lupus nephritis (6.5%) and minimal change disease (6.0%) in younger adults (19–64 years), and membranous nephropathy (17.4%), antineutrophil cytoplasmic antibody-associated vasculitis or anti-glomerular basement membrane glomerulonephritis (13.0%), and immunoglobulin A nephropathy (12.5%) in older adults (≥ 65 years). The percentages of patients diagnosed with membranoproliferative glomerulonephritis and immunoglobulin A nephropathy decreased, whereas those with immunoglobulin A vasculitis and diabetic nephropathy increased over the decade. In paediatric patients (< 19 years), immunoglobulin A nephropathy (36.1%), minimal change disease (17.6%), and immunoglobulin A vasculitis (8.6%) were the predominant diagnoses. The percentage of patients diagnosed with immunoglobulin A vasculitis increased over the decade. Based on the sex distribution, minimal change disease and membranous nephropathy were predominant in men aged < 20 and > 40 years, respectively, whereas immunoglobulin A vasculitis and antineutrophil cytoplasmic antibody-associated vasculitis or anti-glomerular basement membrane glomerulonephritis were predominant in women in their 20s and 30s and aged < 50 years, respectively. Immunoglobulin A nephropathy was predominant in men at most ages and in women in their 20s to 40s. Conclusions This study describes the distribution and changes in kidney biopsy diagnoses over 10 years in Japan and paves the way for future research on kidney diseases in adults and children. Graphical abstract

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Childhood nephrotic syndrome

Vivarelli,

Gibson,

Sinha

et al. 2023

The Lancet

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Clinical and histological features in pediatric and adolescent/young adult patients with renal disease: a cross-sectional analysis of the Japan Renal Biopsy Registry (J-RBR)

Cited by 3 publications

References 22 publications

Diagnosis and treatment of IgA nephropathy and IgA vasculitis nephritis in Chinese children

Diagnosis and treatment of IgA nephropathy and IgA vasculitis nephritis in Chinese children

Renal pathology in adult and paediatric population of Japan: review of the Japan renal biopsy registry database from 2007 to 2017

Childhood nephrotic syndrome

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