Clinical and Histological Characteristics of Papillary Thyroid Microcarcinoma: Results of a Retrospective Study in 243 Patients

Roti, Elio; Rossi, Roberta; Trasforini, Giorgio; Bertelli, F.; Ambrosio, Maria Rosaria; Busutti, L.; Pearce, Elizabeth N.; Braverman, Lewis E.; Uberti, Ettore C. degli

doi:10.1210/jc.2005-2372

Cited by 238 publications

(235 citation statements)

References 28 publications

Supporting

Mentioning

194

Contrasting

Unclassified

Order By: Relevance

“…Papillary microcarcinomas may present with up to 35% multifocality, 24 up to 30% lymph node metastasis, 3 up to 28% extrathyroidal extension 3 and up to 2% distant metastases. 2 In our study, some features were even more prevalent: multifocality was found in 32% of the papillary microcarcinomas, extrathyroidal extension in 35% and regional lymph node metastasis in 37%, although direct comparison would be inappropriate, because a large number of our cases were non-incidental papillary microcarcinoma with lymph node dissection. Moreover, some authors have insisted that there was no statistically significant difference between papillary microcarcinomas and papillary thyroid carcinomas at clinical follow-up.…”

Section: Discussionmentioning

confidence: 53%

“…1 It is the most common form of papillary carcinoma, 1 comprising almost half of the papillary thyroid carcinomas reported in recent studies. [2][3][4] Most papillary microcarcinomas remain silent and have a slow clinical course, but some behave aggressively, with local recurrence [5][6][7] and early distant metastasis, 5,7 giving rise to clinically significant disease. Furthermore, a papillary microcarcinoma may occasionally be the primary lesion of a lymph node metastasis presenting clinically as a neck mass.…”

mentioning

confidence: 99%

See 1 more Smart Citation

S100A4 expression is associated with lymph node metastasis in papillary microcarcinoma of the thyroid

et al. 2008

View full text Add to dashboard Cite

The detection of papillary microcarcinomas of the thyroid is increasing due to frequent use of ultrasound and fine-needle aspiration biopsy. Although most of the papillary microcarcinomas remain quiescent and follow an indolent clinical course, some behave aggressively and metastasize early, giving rise to clinically significant disease. There have been few studies concerning factors predictive of lymph node metastasis in papillary microcarcinomas. We analyzed the expression of S100A4, cyclin D1, p27 and MUC1, the presence of the BRAF V600E mutation and the clinicopathological features of the tumors, including patient age, tumor size (Z5 vs o5 mm), extrathyroidal extension, multifocality, histological subtype, sclerosis and encapsulation, in a series of 198 papillary microcarcinomas in relation to lymph node metastasis to determine the predictive factors of lymph node metastasis. On univariate analysis, tumor size of 5 mm or more, extrathyroidal extension, multifocality, sclerosis and the expression of S100A4 and cyclin D1 predicted lymph node metastasis, whereas patient age, expression of p27 and MUC1 and the BRAF V600E mutation did not. Moreover, tumor size 5 mm or more, multifocality and expression of S100A4, especially its strong expression in the invasive fronts, were significantly associated with macrometastasis and lateral node metastasis. On multivariate analysis, multifocality and expression of S100A4 were found to be common independent predictive factors of lymph node metastasis, macrometastasis and lateral node metastasis. In conclusion, S100A4 expression in papillary microcarcinomas may indicate the presence of nodal metastasis. Thus, S100A4 immunohistochemistry may be valuable for predicting metastatic potential in papillary microcarcinomas.

show abstract

Section: Discussionmentioning

confidence: 53%

mentioning

confidence: 99%

S100A4 expression is associated with lymph node metastasis in papillary microcarcinoma of the thyroid

et al. 2008

View full text Add to dashboard Cite

show abstract

“…2.3Current investigations show there are two different varieties of PTMC, tumors with benign biological and clinical courses and those aggressive tumors in terms of lymph node and distant metastasis (Lin et al, 1997;Roti et al, 2006). These aggressive tumors have some characteristics such as larger tumor size, multifocality , extrathyroid invasion and so on.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Nodal Metastasis in cN0 Papillary Thyroid Microcarcinoma

Zhang¹,

Liu²,

Liu³

et al. 2015

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…They highlight the need for thyroid function investigations and ultrasound scans followed by FNAB of thyroid nodules when required, every 1-3 years, depending on the presence or absence of thyroid dysfunction, small nodules, and duration of follow-up. This screening should begin at the time of TBI, to provide baseline information, and extend over a followup period of at least 30 years, to facilitate the detection of microcarcinomas that have a more favorable prognosis than larger tumors (53). However, evidencebased rational strategies concerning the duration of follow-up, the time interval between screening events by ultrasound scan, and thyroid function assessments detecting even subtle thyroid dysfunction and treatment are lacking, and little is known about risk/benefit ratio for health outcomes.…”

Section: Discussionmentioning

confidence: 99%

Malignant and benign thyroid nodules after total body irradiation preceding hematopoietic cell transplantation during childhood

Vivanco

Dalle²,

Alberti³

et al. 2012

European Journal of Endocrinology

View full text Add to dashboard Cite

Background: The risk of radiation-induced benign and malignant thyroid nodules is well known. Objective: The aim of this study was to determine the occurrence of thyroid nodules and carcinomas after fractionated total body irradiation (TBI) preceding hematopoietic stem cell transplantation (HSCT) for malignant hematological disease during childhood. Methods: We conducted a retrospective university hospital-based observational study. The participants were 76 patients receiving fractionated TBI between 1989 and 2009 as part of the conditioning regimen for HSCT to treat malignant hematological disease, with a median age of 8.2 (5.7-11.4) years, for whom the last ultrasound examination was performed at a median age of 14.2 (11.2-17) years. The main outcome measure was cumulative incidence of thyroid nodules detected by ultrasound scans followed by biopsy if necessary. Results: Thyroid nodules were examined in 21 (28%) patients, six (29%) of whom were diagnosed with thyroid carcinoma at the age of 2.2-18.6 years after TBI. The cumulative incidence of nodule occurrence increased with increasing time from diagnosis. The 10-year cumulative incidence of benign and malignant thyroid nodules was 16% (95% confidence interval (CI) 4-27%) and 8% (95% CI 0-16%) respectively. Seventeen (22%) patients had hypothyroidism (compensated nZ12, in five patients it was transient). No significant independent risk factors were identified in the multivariable competing risk model as a function of nodule occurrence. Conclusion: Short-term and life-long monitoring, with screening for nodules of the thyroid gland using ultrasound scans, is recommended for survivors subjected to TBI for HSCT during childhood.

show abstract

Clinical and Histological Characteristics of Papillary Thyroid Microcarcinoma: Results of a Retrospective Study in 243 Patients

Abstract: PTMC is prevalent in the population. Among patients with PTMC, tumor size more than 8 mm is associated with more aggressive disease.

Cited by 238 publications

References 28 publications

S100A4 expression is associated with lymph node metastasis in papillary microcarcinoma of the thyroid

S100A4 expression is associated with lymph node metastasis in papillary microcarcinoma of the thyroid

Risk Factors for Nodal Metastasis in cN0 Papillary Thyroid Microcarcinoma

Malignant and benign thyroid nodules after total body irradiation preceding hematopoietic cell transplantation during childhood

Contact Info

Product

Resources

About