Clinical and Histological changes after ridge preservation with two xenografts: preliminary results from a multicentre randomized controlled clinical trial

Barone, Antonio; Toti, Paolo; Quaranta, A. Alberigi; Alfonsi, Fortunato; Cucchi, Alessandro; Negrí, Bruno; Felice, Roberto Di; Marchionni, Silvia; Calvo-Guirado, José Luís; Covani, Ugo; Nannmark, Ulf

doi:10.1111/jcpe.12655

Cited by 56 publications

(103 citation statements)

References 30 publications

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“…Results showed that the use of collagen membrane alone or associated to porcine-derived bone improves the healing bone process, compared to that of extraction sites spontaneously healed. These outcomes are in agreement with data reported by other studies [17,18], and confirm that porcine-derived bone and reabsorbable membrane are effective in maintaining the post-extractive ridge volume, compared to spontaneously healed extraction sites. As previously reported [16] the comparative clinical results between the three experimental groups, showed that at 4 months re-entry surgery, extraction sockets without severe walls deficiencies and with vestibular bone thickness ≥ 1.5 mm, grafted with porcine-derived bone and/or covered by collagen membrane have significantly lower vertical and horizontal bone changes compared to extraction sockets left to heal spontaneously.…”

Section: Discussionsupporting

confidence: 92%

“…Contradictory considerations are reported in literature on the “biological meaning” of residual graft particles present in biopsy samples harvested from regenerated extraction sockets. Highlighting that the almost complete incorporation of the residual graft particles in bone creates a dense and hard tissue network with particles completely surrounded by vital bone, some authors [17,18] suggested that, once the biomaterial particles are embedded in mineralized bone, they acted similarly to the host bone, providing a similar biologic support. On the contrary, other authors [31,32] having identified the presence of multinucleated cells and of osteoclastic activity around xenogenic bone residual particles suggested that these may influence the remodelling process and delay the socket healing.…”

Section: Discussionmentioning

confidence: 99%

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Bone Healing in Extraction Sockets Covered With Collagen Membrane Alone or Associated With Porcine-Derived Bone Graft: a Comparative Histological and Histomorphometric Analysis

Guarnieri

Testarelli

Stefanelli

et al. 2017

JOMR

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ObjectivesThe present paper reports data of a randomized study aimed to analyse and compare the histologic and histomorphometric aspects of bone healing in extraction sites covered with collagen membrane alone or associated with porcine-derived bone graft.Material and MethodsThirty patients, with single extraction sockets without severe bone wall defects in the premolar/molar region, were included. Ten extraction sockets were grafted with porcine-derived bone and covered with collagen membrane (group 1), 10 sites were covered with collagen membrane alone (group 2), and 10 sites healed spontaneously (group 3). After 4 months of healing, 26 (8 in group 1, 9 in group 2, and 9 in group 3) bone core specimens were harvested for histologic evaluation, then dental implants were placed.ResultsSites in the group 1 and in the group 2 showed similar histologic and histomorphometric results without significantly differences in the percentage of vital bone (57.43% [SD 4.8] vs. 60.01% [SD 3.2]), and non-mineralized connective tissue 22.99% (SD 5.3) vs. 18.53% (SD 6.2). In group 1 a 16.57% (SD 3.8) of residual material was found. ConclusionsResults showed that the use of collagen membrane alone or associated to porcine-derived bone improves the healing bone process compared to that of extraction sites spontaneously healed. Moreover, histomorphometric data related to bone quality, indicated that extraction sites without severe walls defects and with a vestibular bone thickness > 1.5 mm, treated with a low resorbtion rate collagen membrane alone, do not need more than 4 months for dental implant insertion.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Bone Healing in Extraction Sockets Covered With Collagen Membrane Alone or Associated With Porcine-Derived Bone Graft: a Comparative Histological and Histomorphometric Analysis

Guarnieri

Testarelli

Stefanelli

et al. 2017

JOMR

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“…Analysis of primary outcomes revealed no significant histological differences in mean vital bone formation between ridge preservation with cancellous bovine xenograft and cancellous porcine xenograft after 18 to 20 weeks of healing. For the porcine group, vital bone formation of 31.3% in the current study was similar to previously reported results for ridge preservation using cortical and collagenated cortico‐cancellous porcine xenograft showing vital bone formation of 36.8% and 41.4%, respectively, after 3 months of healing . Conversely, the ridge preservation study of Guarnieri et al .…”

Section: Discussionsupporting

confidence: 91%

Ridge preservation following tooth extraction using bovine xenograft compared with porcine xenograft: A randomized controlled clinical trial

Lai

Michalek

Liu

et al. 2019

Journal of Periodontology

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Background The primary purpose of this study was to histologically determine if there is a significant difference in new bone formation, residual graft material, and connective tissue/other when ridge preservation is accomplished using a bovine versus a porcine xenograft. Methods Forty‐four patients needing a single rooted tooth extraction and ridge preservation in preparation for dental implant placement were recruited in the study. After minimally traumatic tooth extraction, alveolar ridge dimensions were measured using a custom‐fabricated acrylic stent. Patients were then randomized 1:1 to receive ridge preservation using either bovine or porcine xenograft material. A trimmed dense polytetrafluoroethylene (d‐PTFE) membrane was overlaid on the graft material, the mucoperiosteal flaps were replaced, and the surgical site was sutured. After 18 to 20 weeks of wound healing, sites were surgically re‐entered, ridge dimensions were again measured using the previously fabricated acrylic stents and a bone core sample of the grafted site was harvested for histomorphometric analysis. Results Thirty eight of the 44 enrolled patients completed the study, 17 from the bovine group and 21 from the porcine group. Histologically, there were no statistically significant differences between the groups for mean percentage of vital bone formation (bovine = 36.21%, porcine = 31.27%, P = 0.49), residual graft material (bovine = 20.47%, porcine = 19.52%, P = 0.82) and connective tissue/other (bovine = 43.32%, porcine = 49.21%, P = 0.19). For secondary outcomes, there were no significant differences between the groups for mean change in buccal ridge height, lingual ridge height, and ridge width. However, a higher number of patients in the porcine group had additional grafting at the time of implant placement, either because of thin buccal plate or failure of implant stability. Conclusion The findings suggest that ridge preservation with porcine xenograft results in comparable histomorphometric outcomes and dimensional stability with bovine xenograft.

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“…To minimize this physiologic process, several therapeutic attempts have been investigated, a concept defined as “alveolar ridge preservation” (ARP) . Over the past 2 decades, studies have used different techniques and materials, all aimed at reducing the post‐extraction alveolar ridge atrophy . Among many different materials that have been used throughout the literature, the autogenous bone has been regarded as the gold standard for replacing or regenerating the resorbed alveolar ridge due to the fact that it consists of all necessary properties required in bone regeneration (osteoconduction, osteoinduction, and osteogenesis) .…”

Section: Introductionmentioning

confidence: 99%

Time analysis of alveolar ridge preservation using a combination of mineralized bone‐plug and dense‐polytetrafluoroethylene membrane: A histomorphometric study

Wen

Barootchi

Huang

et al. 2019

Journal of Periodontology

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Background The objective of this study was to histologically evaluate and compare vital bone formation, residual graft particles, and fraction of connective tissue (CT)/other tissues between three different time points at 2‐month intervals after alveolar ridge preservation with a cancellous allograft and dense‒polytetrafluoroethylene (d‐PTFE) membrane. Methods Ridge preservation with a cancellous allograft and d‐PTFE membrane was performed at 49 extraction sockets (one per patient). Volunteers were assigned to implant placement at three different time points of 2, 4, and 6 months, at which time core biopsies were obtained. Histomorphometric analysis was performed to determine the percentages of vital bone, residual graft particles, and connective tissue/other non‐bone components, and subjected to statistical analyses. Results There was a statistically significant difference in the amount of vital bone at every time point from 28.31% to 40.87% to 64.11% (at 2‐, 4‐, and 6‐month groups, respectively) (P < 0.05). The percentage of residual graft particles ranged from 44.57% to 36.16% to 14.86%, showing statistical significance from 4 to 6 months (21.29%, P < 0.001), and 2 to 6 months (29.71%, P < 0.001), while there were no significant differences for the amount of CT/other tissue among the different time points. Conclusions This study provided the first histologic comparison of alveolar ridge preservation using a cancellous allograft and d‐PTFE membrane at three different time points. Extraction sockets that healed for 6 months produced the highest amount of vital bone in combination with the least percentage of residual graft particles, while similar results were observed for the fraction of CT/other tissues between the three time points.

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Clinical and Histological changes after ridge preservation with two xenografts: preliminary results from a multicentre randomized controlled clinical trial

Abstract: The ridge preservation procedures had significantly better outcomes when compared to natural healing. The biomaterials did not differ for maintenance of bone width; even though, the bone height seemed to be better preserved with the cortical porcine bone.

Cited by 56 publications

References 30 publications

Bone Healing in Extraction Sockets Covered With Collagen Membrane Alone or Associated With Porcine-Derived Bone Graft: a Comparative Histological and Histomorphometric Analysis

Bone Healing in Extraction Sockets Covered With Collagen Membrane Alone or Associated With Porcine-Derived Bone Graft: a Comparative Histological and Histomorphometric Analysis

Ridge preservation following tooth extraction using bovine xenograft compared with porcine xenograft: A randomized controlled clinical trial

Time analysis of alveolar ridge preservation using a combination of mineralized bone‐plug and dense‐polytetrafluoroethylene membrane: A histomorphometric study

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