Clinical and histological assessment of neo-adjuvant chemotherapy including CDDP for oral cancer. 1. Possibility of a reductive excision in CR cases.

健, 和田; 昌和, 原田; 展雄, 森田; 和幸, 宮田; 忠幸, 坂本

doi:10.5843/jsot.5.278

Cited by 2 publications

(1 citation statement)

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“…Preoperative chemotherapy and radiotherapy are possible treatment strategies for progressive oral SCC [36,37], and in this series of cases, many advanced stage (stages III and IV) patients had been treated with preoperative therapy. It was reported that even if tumor size was reduced by preoperative therapy in clinical assessment, there was insufficient reduction in postoperative pathological specimens [38][39][40]. Therefore, many investigators suggested that reduction surgery was not indicated in oral SCC.…”

Section: Discussionmentioning

confidence: 99%

Risk factors in securing successful surgical resection of oral squamous cell carcinoma

Nakanishi

Yamada

Nishizawa

et al. 2018

Oral Science International

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The purpose of this retrospective study was to analyze the factors that had a significant effect on securing a successful surgical resection (surgical margin) in oral cancer surgery. One hundred forty‐eight consecutive patients who underwent planned radical resection of oral squamous cell carcinoma (SCC) were analyzed. Successful resection was judged if pathological examination of the surgical specimen revealed a clear surgical margin (no SCC within 5 mm, n = 116), while an unsuccessful resection was judged if there was a close and involved surgical margin (SCC within 5 mm, n = 21; and SCC at margin, n = 11). Univariate analyses showed that gender, age, and T‐classification had significant influence on successful surgical resection. The results of multivariate logistic regression analysis showed that age (odds ratio [OR] = 1.042, 95% CI = 1.001‐1.084), T‐classification (OR = 1.656, 95% CI = 1.060‐2.587), and the presence of preoperative treatment (OR = 2.868, 95% CI = 1.047‐7.85) had significant effects on successful surgical resection. The results of this study suggested that successful resection of oral SCC was difficult in patients with either older age or advanced (T4) tumor. It is also suggested that preoperative therapy had a positive effect on securing a pathologically clear surgical margin.

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Section: Discussionmentioning

confidence: 99%