Clinical and haematological findings in 70 naturally occurring cases of canine babesiosis

Sudi, Abdullahi; Mohammed, Abdullahi; Trimnell, A.R.; Sannusi, A.; Alafiatayo, Ruth

doi:10.1111/j.1748-5827.1990.tb00750.x

Cited by 32 publications

(24 citation statements)

References 3 publications

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“…infections typically comprises a syndrome characterised by hyperthermia, anaemia and haemoglobinuria [2,7], although in many hosts subclinical or mild infection is common. Similarly to other "small" babesia, in dogs, B. annae infection causes severe illness.…”

Section: Introductionmentioning

confidence: 99%

Serum protein response and renal failure in canine Babesia annae infection

Camacho¹,

Guitian

Pallas

et al. 2005

Vet. Res.

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-Babesia annae piroplasms have recently been recognised as a cause of infection and disease among dogs in Europe. The pathogenesis and clinical implications of this emerging disease remain poorly understood. We conducted this study to describe the electrophoretic profiles associated with the infection and to determine if B. annae associated azotaemia is caused by renal failure. We examined by microscopy 2 979 canine blood samples submitted to a diagnostic laboratory in NW Spain between September 2001 and April 2002. Small ring-shaped piroplasms were detected in blood smears of 87 samples and the identity of 58 of these presumptive cases were confirmed by PCR. This group of 58 infected dogs and a reference group of 15 healthy non-infected dogs were our study population. For all the dogs, serum protein response to -albumin, alpha-1 globulin, alpha-2 globulin, beta globulin and gamma globulin-was measured by capillary electrophoresis. The response of infected and non-infected dogs was compared and within infected dogs, the response of those with azotaemia (19) was compared with that of non-azotaemic dogs (39). Infected dogs presented a significant elevation of total proteins and all the different globulin fractions, and significantly lower levels of albumin compared to non-infected dogs. Among infected dogs, those presenting azotaemia had significantly lower concentrations of total proteins, albumin, beta and gamma globulins, and significantly higher values of alpha-2 globulin. Specific gravity was below the threshold of 1 025 for all dogs with azotaemia for which a urine sample was available (7) suggesting that azotaemia, in these dogs was of renal origin. Azotaemic dogs had higher concentrations of cholesterol and triglycerides, probably as a result of a liver compensatory response to the loss of proteins. We conclude that serum protein response in B. annae infected dogs corresponds to the pattern of a haemolytic syndrome with intense inflammatory reaction and that the azotaemia associated to the infection is very likely of renal origin. serum proteins / Babesia annae / azotaemia / renal failure

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Section: Introductionmentioning

confidence: 99%

Serum protein response and renal failure in canine Babesia annae infection

Camacho¹,

Guitian

Pallas

et al. 2005

Vet. Res.

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“…Peracute infection is rare and characterized by signifi cant tissue damage and high mortality rate. Acute babesiosis is characterized by fever, tachycardia with hyperdynamic pulse pressures, lethargy, varying degrees of hemolytic anaemia, pallor, anorexia, vomiting, dehydration, splenomegaly, lymphadenomegaly, thrombocytopenia, jaundice, pigmenturia, hypotension and water hammer pulse [21,[125][126][127][128][129]. Chronic infections are often asymptomatic, since many "carrier" dogs do not have any clinical signs as a result of premunition or concomitant immunity unless their health deteriorates, as a consequence of immunosuppressive therapy, splenectomy, or any other immune-compromised situation [130].…”

Section: Clinical Signs and Clinicopathological Abnormalities Of Babementioning

confidence: 99%

Canine Babesiosis: Where Do We Stand?

et al. 2018

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Canine babesiosis is a tick-borne disease caused by protozoal haemoparasites of different Babesia species. Babesiosis is one of the most important globally extended and quickly spreading tick-borne infections of dogs. This comprehensive review gives an in-depth overview of Babesia species currently identifi ed in dogs together with relevant vector tick species and their geographical distribution, life cycle and transmission of parasite. The main mechanisms in the pathogenesis of babesiosis are described and elucidated by recent literature overview. As Babesia infection causes a disease with very variable clinical manifestations, special attention is given to clinical signs, laboratory features and clinicopathological fi ndings. The diagnosis of canine babesiosis by microscopy, serological and molecular methods is reviewed, together with recent advances in mass spectrometry based assays. Accurate detection and species recognition are important for the selection of the appropriate therapy, monitoring and prediction of the outcome of the disease. Finally, guidelines for the treatment and prevention of canine babesiosis are given.

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“…Η αναιμία, η ουδετεροφιλική λευκοκυττάρωση (σπα νιότερα και λευχαιμοειδής αντίδραση) και η θρομβοκυτ-ταροπενία αποτελούν τα συχνότερα αιματολογικά ευρή ματα, ενώ η λεμφοκυττάρωση και η εωσινοφιλία είναι λι γότερο συχνά 32 ' 35ΜΜ . Η αναιμία τις περισσότερες φορές εί ναι αναγεννητικού τΰπου, ενώ η συχνά θετική άμεση κα τά Coomb δοκιμή και η δοκιμή της αυτοαιμοσυγκόλλησης επιβεβαιώνουν την ανοσολογική της φΰση 13 32 .…”

Section: κλινικα και εργαστηριακα ευρηματαunclassified

Canine babesiosis

MYLONAKIS¹,

BILLINIS²,

KOUTINAS³

et al. 2018

J Hellenic Vet Med Soc

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The causative agents of canine babesiosis are Babesia canis and B. gibsoni which are transmitted by various hard tick species and blood transfusions. In the hyperacute form of the disease hypothermia, shock, severe metabolic acidosis and disseminated intravascular coagulation usually precede the death of the dog occuring in less than 24 hours. Severe anemia, icterus, splenomegaly and peripheral lymphadenopathy characterize the acute form of the disease. Intermittent fever and progressive loss of body weight may be noticed in the chronic form of babesiosis, while its many atypical clinical manifestations (e.g. ascites, gastrointestinal signs, CNS disease, subcutaneous edema, masticatory myositis) often cause diagnostic confusion. The organism detection on RBC in thin blood smears made from the buffy coat is a must for definitive diagnosis. The IFA test is a good choice for screening large numbers of dogs for detecting the asymptomatic carriers. Complete parasitological cure can be obtained with imidocarb dipropionate, pentamidine isethionate or diminazene aceturate, while metronidazole and clindamycin have been recently suggested as good alternatives. Supportive care is considered crucial for the survival of the severely affected animals. While effective tick control is the mainstay of prevention, doxycycline and imidocarb may also play a significant role to that goal. The effectiveness of a killed vaccine is still a matter of controversy.

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Clinical and haematological findings in 70 naturally occurring cases of canine babesiosis

Cited by 32 publications

References 3 publications

Serum protein response and renal failure in canine Babesia annae infection

Serum protein response and renal failure in canine Babesia annae infection

Canine Babesiosis: Where Do We Stand?

Canine babesiosis

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