Clinical and Genetic Risk Factors for Perianal Crohn's Disease in a Population-Based Cohort

Abstract

This study suggests that younger age at diagnosis, complicated disease behavior, and ileal disease location are risk factors for perianal CD. In addition, this paper represents the first report of an association of the NCF4 gene with perianal disease.

The Spectrum of Perianal Crohn’s Disease in a Population-Based Cohort

“…This approach has also already allowed meaningful investigation of the factors predisposing to PCD in this cohort. 23 The challenge for future research remains to better define both these factors and those governing response to emerging medical and surgical therapies for PCD.…”

Predictors of response to infliximab in paediatric perianal Crohn's disease

“…1,2 Treatment of perianal lesions has long been dismaying, with high rates of recurrence and proctectomy in adult population-based studies before the era of biologic therapies. 3 Infliximab (IFX) was the first anti-TNF agent to show efficacy in fistula closure.…”

The role of NOD1/CARD4 and NOD2/CARD15 genetic variations in lung cancer risk

“…This NOD2/CARD15 variant is generally investigated in Crohn's disease [22][23][24] but has also been studied in some cancer types [5,18]. Forrest et al reported that the p.Leu1007fsX1008 polymorphism may influence the risk of non-Hodgkin lymphoma by altering host immune responsiveness to microbial agents [18].…”