Clinical and Genetic Factors Associated With the Breast Cancer-Related Sleep Disorders: The “CAGE-Sleep” Study–A Cross-Sectional Study

Hajj, Aline; Hachem, Roula El; Khoury, Rita; Nehme, Tamara; Hallit, Souheil; Nasr, Fady; Karak, Fady El; Chahine, Georges; Kattan, Joseph; Khabbaz, Lydia Rabbaa

doi:10.1016/j.jpainsymman.2021.02.022

Cited by 9 publications

(3 citation statements)

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“…As the dependent variable was not normally distributed and the sample size was small ( n = 67), non-parametric tests were used: the Mann-Whitney test to compare means between two groups, Kruskal-Wallis test to compare three or more groups (with post hoc analysis), and Spearman correlation to correlate between continuous, ordinal, or count variables. DNA sampling as well as genotyping assays were performed as previously prescribed [ 51 ]. The genotype alleles were taken once as three categories, then combined and checked for any significant association with the dependent variable.…”

Section: Methodsmentioning

confidence: 99%

Fatigue in breast cancer patients on chemotherapy: a cross-sectional study exploring clinical, biological, and genetic factors

et al. 2022

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Background Cancer-related fatigue (CRF) is one of the most common and distressing complaints reported by cancer patients during chemotherapy considerably impacting all aspects of a patient’s life (physical, psychosocial, professional, and socioeconomic). The aim of this study was to assess the severity of cancer-related fatigue in a group of breast cancer patients undergoing chemotherapy and explore the association between fatigue scores and sociodemographic, clinical, biological, psychiatric, and genetic factors. Methods A cross-sectional pilot study carried out at the oncology outpatient unit of Hôtel-Dieu de France University Hospital recruited 67 breast cancer patients undergoing chemotherapy between November 2017 and June 2019 to evaluate fatigue using the EORTC QLQ-C30 scale (European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire). Genotyping for seven gene polymorphisms (COMT, DRD2, OPRM1, CLOCK, PER2, CRY2, ABCB1) was performed using the Lightcycler® (Roche). Results The prevalence of fatigue was 46.3%. Multivariable analysis taking the fatigue score as the dependent variable showed that a higher number of cycles and a lower hemoglobin level were significantly associated with higher odds of exhibiting fatigue. Moreover, having at least one C allele for DRD2 SNP (vs. TT) was significantly associated with a 4.09 higher odds of expressing fatigue compared to TT patients. Finally, patients with at least one C allele for CLOCK SNP tended to display higher fatigue levels than TT patients. Conclusions Our study showed that anemic breast cancer patients with a high number of chemotherapy cycles and those carrying at least one C allele for DRD2 and CLOCK SNPs are at greater risk of exhibiting fatigue. Since no previous research has reported such genetic results, future studies are necessary to confirm our findings.

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Section: Methodsmentioning

confidence: 99%

Fatigue in breast cancer patients on chemotherapy: a cross-sectional study exploring clinical, biological, and genetic factors

et al. 2022

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“…The number of cycles was recorded as the "number of chemotherapy cycles". More details are described elsewhere [39].…”

Section: Patient's Sociodemographic and Clinical Informationmentioning

confidence: 99%

Clinical and genetic factors associated with anxiety and depression in breast cancer patients: a cross-sectional study

et al. 2021

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Background Despite the progress in assessment and treatment of breast cancer, being diagnosed with it or receiving chemotherapy treatment is still conceived as a traumatic experience. Women develop negative thoughts about life and death with detrimental effects on their daily physical functioning/activities, emotional state and overall quality of life. The aim of our study was to evaluate the level of anxiety and depression among breast cancer patients receiving chemotherapy and explore the correlation between these psychological disorders, clinical, sociodemographic and genetic factors. Methods A cross-sectional study was conducted among breast cancer patients undergoing intravenous chemotherapy at the oncology outpatient unit of Hôtel-Dieu de France hospital (November 2017–June 2019; Ethical approval number: CEHDF1016). All patients gave their written informed consent and completed several validated scales, including the Hospital Anxiety and Depression scale (HADS) for the assessment of anxiety and depression. Sleep quality, insomnia, cognitive function, fatigue and pain were also evaluated. Genotyping for certain gene polymorphisms (CLOCK, PER2, CRY2, OPRM1, ABCB1, COMT, DRD2) was performed using the Lightcycler® (Roche). Results A total of 112 women was included. The prevalence of depression was 43.4%, and 56.2% of the patients reported anxiety (based on the HADS classification). Multivariable analysis showed that higher cognitive scores and taking fosaprepitant were significantly associated with lower depression and anxiety scores. Moreover, being married compared to single was also associated with lower depression scores, whereas higher PSQI scores (worse sleep quality) and having the PER2 AA variant genotype compared to GG were significantly associated with higher depression scores. Finally, reporting a more severe insomnia and having the COMT Met/Met genotype were significantly associated with a higher anxiety score. Conclusions Our study demonstrated a strong relationship between depression scores and cognitive impairment, sleep quality, marital status, fosaprepitant intake, and PER2 polymorphism, while anxiety scores were correlated to cognitive impairment, insomnia severity, fosaprepitant intake, and COMT polymorphism. The association with PER polymorphism was not previously reported. Identification of genetic and clinical risk factors for anxiety and depression would help clinicians implement an individualized management therapy aiming at preventing and alleviating the burden of these symptoms in breast cancer patients, hence improving their overall quality of life.

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“…The sample size was calculated using Open EPI software and similar previous studies. 16 , 17 The participants were selected according to the inclusion criteria from the female patients referring to the cancer research centre of Shohadaye Tajrish Hospital in Tehran, Iran. The inclusion criteria included females with confirmed BC, diagnosed recently, age between 35 and 70 years and consent to participate in the study.…”

Section: Methodsmentioning

confidence: 99%

The association between fat mass and obesity‐associated (FTO) genotype and serum vitamin D level in breast cancer patients

Mokhtari

Doaei

Jalili

et al. 2021

J Cellular Molecular Medi

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Clinical and Genetic Factors Associated With the Breast Cancer-Related Sleep Disorders: The “CAGE-Sleep” Study–A Cross-Sectional Study

Cited by 9 publications

References 49 publications

Fatigue in breast cancer patients on chemotherapy: a cross-sectional study exploring clinical, biological, and genetic factors

Fatigue in breast cancer patients on chemotherapy: a cross-sectional study exploring clinical, biological, and genetic factors

Clinical and genetic factors associated with anxiety and depression in breast cancer patients: a cross-sectional study

The association between fat mass and obesity‐associated (FTO) genotype and serum vitamin D level in breast cancer patients

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