Abstract:Background: Little is known about clinical and genetic factors that predict the long-term response of anti-TNF therapy are limited in Japanese patients with Crohn’s disease (CD).
Methods: Association between clinical factors and cumulative clinical relapse-free rates were investigated in 464 patients with CD (373 anti-TNF naïve and 91 anti-TNF switch patients). A genome-wide association study (GWAS) was performed using Cox proportional hazards model. Genotype data of 5,657,947 SNPs from 275 anti-TNF naïve pati… Show more
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