Clinical and genetic characterization of severe influenza B-associated diseases during an outbreak in Taiwan

Li, Wen Chen; Shih, Shin Ru; Huang, Yhu Chering; Chen, Guang-Wu; Chang, Shih Cheng; Hsiao, Mei Jen; Tsao, Kuo Chien; Lin, Tzou Yien

doi:10.1016/j.jcv.2007.11.026

Cited by 46 publications

(34 citation statements)

References 20 publications

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“…This needs careful interpretation. We have very limited data on gastrointestinal tract symptoms, and no association was reported between clinical symptoms and influenza genetic variation in previous influenza B virus and pandemic A/H1N1 studies (41,53,54). A better understanding of the association between demographic and clinical features and virus genetic variation will require additional data and long-term studies from other places.…”

Section: Discussionmentioning

confidence: 97%

Differing Epidemiological Dynamics of Influenza B Virus Lineages in Guangzhou, Southern China, 2009-2010

Tan

Guan

Lam

et al. 2013

J Virol

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The epidemiological and evolutionary dynamics of the two cocirculating lineages of influenza B virus, Victoria and Yamagata, are poorly understood, especially in tropical or subtropical areas of Southeast Asia. We performed a phylogenetic analysis of the hemagglutinin (HA) and neuraminidase (NA) sequences of influenza B viruses isolated in Guangzhou, a southern Chinese city, during 2009 to 2010 and compared the demographic and clinical features of infected patients. We identified multiple viral introductions of Victoria strains from both Chinese and international sources, which formed two phylogenetically and antigenically distinct clades (Victoria 1 and 2), some of which persisted between seasons. We identified one dominant Yamagata introduction from outside China during 2009. Our phylogenetic analysis reveals the occurrence of reassortment events among the Victoria and Yamagata lineages and also within the Victoria lineage. We found no significant difference in clinical severity by influenza B lineage, with the exceptions that (i) the Yamagata lineage infected older people than either Victoria lineage and (ii) fewer upper respiratory tract infections were caused by the Victoria 2 than the Victoria 1 clade. Overall, our study reveals the complex epidemiological dynamics of different influenza B lineages within a single geographic locality and has implications for vaccination policy in southern China.

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Section: Discussionmentioning

confidence: 97%

Differing Epidemiological Dynamics of Influenza B Virus Lineages in Guangzhou, Southern China, 2009-2010

Tan

Guan

Lam

et al. 2013

J Virol

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“…Influenza A and B viruses can cause annual epidemics and severe illnesses in patients. Although the morbidity and mortality rates due to influenza B infection are generally lower than those for influenza A infections, the former strain is commonly associated with gastrointestinal symptoms and viral myocarditis [15,20]. Unlike influenza A, influenza B is not divided into subtypes based on hemagglutinin (HA) and neuraminidase (NA), but it has two phylogenetically and antigenically distinct lineages (the B/Victoria/2/87-like [Victoria] lineage and, since 1983, the B/Yamagata/16/88-like [Yamagata] lineage) [17,27].…”

Section: Introductionmentioning

confidence: 99%

Molecular epidemiology and evolution of influenza A and B viruses during winter 2013-2014 in Beijing, China

et al. 2015

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In this study, we investigated the molecular epidemiology and evolution of influenza viruses from patients infected during the 2013-2014 influenza season in Beijing. A phylogenetic analysis of the hemagglutinin (HA) and neuraminidase (NA) sequences of influenza A and B viruses from 18 patients (6 A(H1N1)pdm09, 4 H3N2, and 8 influenza B virus) was performed. Among the influenza A viruses, A(H1N1)pdm09 was the dominant subtype, whereas the B/Yamagata lineage was predominant for influenza B. The influenza B HA and NA strains in Beijing were dominated by reassortants derived from the Yamagata lineage and the Victoria lineage, respectively. All six A(H1N1)pdm09 strains fell into the 6B genetic group with amino acid substitutions D97N, S185T, K163Q, and A256T; the four H3N2 strains fell into genetic group 3C.3 with substitutions T128A, R142G, N145S, and V186G, and the eight influenza B strains were categorized into subgroup 3.1 and harbored an N217S mutation. Two new mutations (K180Q and G187E at the Sa and Ca antigenic sites of the H1 segment, respectively), which were not detected during the preceding influenza season, were identified. Mutations N131K, S165I, N181Y, and D212N in HA of influenza B mapped to the 120-loop, 150-loop, 160-loop, and 190-helix, respectively. Our results reveal the molecular epidemiology and phylogenetic characteristics of influenza viruses within a single geographic location and can have implications for vaccination selection in northern China.

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“…Influenza is associated with a wide spectrum of complications such as croup, tracheobronchitis, bronchiolitis, pneumonia [35], acute otitis media [43], sinusitis [52], acute exacerbations in asthmatic children [33], febrile seizures [6], myositis [25], myocarditis [15], encephalitis [27] and Reye's syndrome [4]. Several studies have demonstrated that influenza disease in children has considerable socioeconomic impact on the children themselves and concerning families [18,36].…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of influenza A and B in German infants and adolescents

Sauerbrei

Schmidt-Ott

Hoyer³

et al. 2009

Med Microbiol Immunol

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The objective of this study was to provide seroepidemiological information on influenza A and B antibodies in children and adolescents. Viral immunoglobulin G antibodies were determined retrospectively using enzyme-linked immunosorbent assays in a group of 1,111 children and adolescents. Sera (809) from healthy adult blood donors served as controls. In children, the prevalence of antibodies against influenza A was 82.0% and against influenza B 9.6%, whereas in adults the prevalence of antibodies against influenza A was calculated as 99.4% and against influenza B 56.7%. After decline of maternal antibodies during the first year of life, there was an increase of prevalence of influenza A antibodies up to 100% by the age of 12 years. In contrast, only 1-2% of children up to 9 years had influenza B antibodies increasing to 25% by the age of 18 years and to 70% among adults aged 30 years. Children aged 0-6 years had significantly lower concentrations and >12-15-year-old adolescents had significantly higher concentrations of antibodies against influenza A than adults. For all age groups of children and adolescents, significantly lower antibody concentrations against influenza B were measured in comparison to the blood donor control group. In conclusion, the annual influenza vaccination in children and adolescents may improve considerably the protection against influenza virus infection occurring during epidemics.

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Clinical and genetic characterization of severe influenza B-associated diseases during an outbreak in Taiwan

Cited by 46 publications

References 20 publications

Differing Epidemiological Dynamics of Influenza B Virus Lineages in Guangzhou, Southern China, 2009-2010

Differing Epidemiological Dynamics of Influenza B Virus Lineages in Guangzhou, Southern China, 2009-2010

Molecular epidemiology and evolution of influenza A and B viruses during winter 2013-2014 in Beijing, China

Seroprevalence of influenza A and B in German infants and adolescents

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