Clinical and Genetic Characteristics of Thymoma Patients With Autoimmune Hepatitis and Myocarditis

Yu, Xin-tao; Yu, Lei; Du, Xin; Yu, Zhen; Yang, Xingguo; Jiang, Yi

doi:10.3389/fonc.2021.746304

Cited by 3 publications

(2 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thymus is a crucial immune organ that has an impact on T-cell homeostasis and function. Thymic tumors such as thymoma have been associated with various autoimmune diseases, including myasthenia gravis (MG), Good's syndrome, dermatomyositis, Addison's disease, and rheumatoid arthritis [12]. These associations may be related to abnormalities in T-cell function.…”

Section: Resultsmentioning

confidence: 99%

The level of IL-8 in TMERA cells as a biomarker for hormonotherapy in thymoma

Yu,

Cui

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

Thymoma is the most common type of neoplasm in the anterior mediastinum. However, it can be challenging to differentiate thymoma from other anterior mediastinum tumors in this region through imaging examinations. Therefore, the identification of a reliable, unique characteristic for the further study of thymoma is crucial. Our study confirms an increase in TEMRA cells in type B thymoma and suggests that the level of IL-8 in TEMRA cells may be a biomarker indicating hormonotherapy can be an effective treatment for patients with type B1 and B2 thymoma patients.

show abstract

Section: Resultsmentioning

confidence: 99%

The level of IL-8 in TMERA cells as a biomarker for hormonotherapy in thymoma

Yu,

Cui

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recently, the accumulation of intrahepatic CD8 + CD103 + perforin + T cells, the so-called tissue resident memory T cells, have been observed in pediatric patients with AIH, particularly in indeterminate acute liver failure ( 31 ). Moreover, a cohort study of 13 patients with hypertransaminasemia and thymoma demonstrated significantly decreased frequencies of CD8 T cells and an elevated CD4/CD8 ratio after thymectomy ( 32 ). As observed in the present case, liver histopathology showed predominant infiltration of CD8 T cells ( Fig.…”

Section: Discussionmentioning

confidence: 99%

Concurrent <i>de novo</i> Thymoma-associated Paraneoplastic Type 1 Autoimmune Hepatitis and Pure Red Cell Aplasia after Thymectomy: A Case Report and Literature Review

et al. 2023

View full text Add to dashboard Cite

The precise manipulation of immune tolerance is the holy grail of immunotherapies for both autoimmunity and cancer immunity. Thymomas are well known to be associated with autoimmune diseases. The exact mechanism by which autoreactivity is induced after thymectomy remains to be elucidated. We herein present the case of a 50-year-old lady with concurrent de novo type 1 autoimmune hepatitis (AIH) and pure red cell aplasia (PRCA), 1 month after undergoing a successful total thymectomy for combined squamous cell carcinoma and thymoma (Masaoka stage II). Corticosteroids yielded short-term effects for both AIH and PRCA. Literature on thymoma-associated AIH, an extremely rare immune-related comorbidity, was also reviewed.

show abstract

An unusual ectopic thymoma clonal evolution analysis: A case report

Zhang

et al. 2023

Open Life Sciences

View full text Add to dashboard Cite

Thymomas and thymic carcinomas are rare and primary tumors of the mediastinum which is derived from the thymic epithelium. Thymomas are the most common primary anterior mediastinal tumor, while ectopic thymomas are rarer. Mutational profiles of ectopic thymomas may help expand our understanding of the occurrence and treatment options of these tumors. In this report, we sought to elucidate the mutational profiles of two ectopic thymoma nodules to gain deeper understanding of the molecular genetic information of this rare tumor and to provide guidance treatment options. We presented a case of 62-year-old male patient with a postoperative pathological diagnosis of type A mediastinal thymoma and ectopic pulmonary thymoma. After mediastinal lesion resection and thoracoscopic lung wedge resection, the mediastinal thymoma was completely removed, and the patient recovered from the surgery and no recurrence was found by examination until now. Whole exome sequencing was performed on both mediastinal thymoma and ectopic pulmonary thymoma tissue samples of the patient and clonal evolution analysis were further conducted to analyze the genetic characteristics. We identified eight gene mutations that were co-mutated in both lesions. Consistent with a previous exome sequencing analysis of thymic epithelial tumor, HRAS was also observed in both mediastinal lesion and lung lesion tissues. We also evaluated the intratumor heterogeneity of non-silent mutations. The results showed that the mediastinal lesion tissue has higher degree of heterogeneity and the lung lesion tissue has relatively low amount of variant heterogeneity in the detected variants. Through pathology and genomics sequencing detection, we initially revealed the genetic differences between mediastinal thymoma and ectopic thymoma, and clonal evolution analysis showed that these two lesions originated from multi-ancestral regions.

show abstract

Clinical and Genetic Characteristics of Thymoma Patients With Autoimmune Hepatitis and Myocarditis

Cited by 3 publications

References 24 publications

The level of IL-8 in TMERA cells as a biomarker for hormonotherapy in thymoma

The level of IL-8 in TMERA cells as a biomarker for hormonotherapy in thymoma

Concurrent <i>de novo</i> Thymoma-associated Paraneoplastic Type 1 Autoimmune Hepatitis and Pure Red Cell Aplasia after Thymectomy: A Case Report and Literature Review

An unusual ectopic thymoma clonal evolution analysis: A case report

Contact Info

Product

Resources

About