Clinical and functional impact of central sensitization on patients with familial Mediterranean fever: a cross-sectional study

Yücel, Feyza Nur; Gezer, Halise Hande; Jandaulyet, Janbubi; Öz, N.; Kasman, Sevtap Acer; Duruöz, Mehmet Tuncay

doi:10.1007/s00296-022-05181-6

Cited by 6 publications

(6 citation statements)

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“…Even in healthy subjects, one-night total sleep deprivation was found to develop anxiety, mechanical pain sensitivity and hyperalgesia [ 48 ]. A recent cross-sectional study found that sleep impairment and psychological status were important confounders of the severity of CS in patients with familial Mediterranean fever [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Biopsychosocial factors should be considered when evaluating central sensitization in axial spondyloarthritis

et al. 2023

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To identify the determinants of central sensitization (CS) in patients with axial spondyloarthritis (axSpA). Central Sensitization Inventory (CSI) was used to determine CS frequency. Disease-related variables including Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Ankylosing Spondylitis Disease Activity Score (ASDAS-CRP/-ESR), Maastricht Ankylosing Spondylitis Enthesitis Score (MASES), Bath Ankylosing Spondylitis Functional Index (BASFI), Ankylosing Spondylitis Quality of Life Questionnaire (ASQoL) and Numeric Rating Scale (NRS) GLOBAL were assessed. Biopsychosocial variables were evaluated by the Multidimensional Scale of Perceived Social Support (MSPSS), Brief Illness Perception Questionnaire (B-IPQ), Hospital Anxiety and Depression Scale (HADS) and subscales for Anxiety (HADS-A) and Depression (HADS-D), and Jenkins Sleep Evaluation Scale (JSS). To determine the predictors of the development and severity of CS, multiple linear and logistic regression analyses were performed. The frequency of CS was 57.4% in the study population ( n = 108). CSI score was correlated with the duration of morning stiffness, BASDAI, ASDAS-CRP, ASDAS-ESR, NRS GLOBAL , BASFI, MASES, ASOoL, JSS, HADS, and B-IPQ total scores ( ρ ranged from 0.510 to 0.853). Multiple regression analysis indicated that BASDAI (OR: 10.44, 95% CI: 2.65–41.09), MASES (OR: 2.47, 95% CI: 1.09–5.56) and HADS-A (OR: 1.62, 95% CI: 1.11–2.37) were independent predictors of the development of CS. Additionally, higher NRS GLOBAL , JSS, HADS-D, and HADS-A scores appeared to determine the severity of CS. This study confirms that worse disease activity, more enthesal involvement, and anxiety independently predict the development of CS. Additionally, higher patient-perceived disease activity, sleep impairment and poor mental health significantly contribute to the severity of CS.

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Section: Discussionmentioning

confidence: 99%

Biopsychosocial factors should be considered when evaluating central sensitization in axial spondyloarthritis

et al. 2023

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“…In the literature, it has been determined that CSI scores are correlated with high disease activities in axSpA and FMF diseases, as well as with biopsychosocial parameters [ 8 , 9 ]. The objective of this study was to assess the correlation between the level of CS and several clinical and functional indicators in individuals diagnosed with FMF, axSpA, and axSpA/FMF.…”

Section: Discussionmentioning

confidence: 99%

“…The study done by Yücel et al aimed to assess the presence of CS in a sample of 100 patients diagnosed with FMF [ 9 ]. The researchers examined many factors including disease activity, anxiety levels, depression levels, sleep quality, and functional status.…”

Section: Discussionmentioning

confidence: 99%

“…Restless leg syndrome and depression have been observed to have a significantly greater prevalence in individuals diagnosed with Behçet's disease when compared to a control group, indicating the presence of CS syndromes in this patient population [ 30 ]. The most common CS syndrome in FMF patients is tension headaches/migraines, and it was found to be significantly higher in the group with a high CS score [ 9 ]. In our study, fibromyalgia was found most frequently in axSpA patients, and chronic fatigue syndrome and fibromyalgia were the most common in FMF patients.…”

Section: Discussionmentioning

confidence: 99%

“…Concurrent pain sensitivity affects pain-related parameters in patient-based activity scores and impairs health-related measures [ 8 ]. Insufficient research has been conducted to adequately assess the impact of CS on disease activity among persons diagnosed with axSpA and FMF [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Central Sensitization in Patients with Familial Mediterranean Fever, Axial Spondyloarthritis, and Both Diseases

Kaya,

Kılıç,

Doğan

et al. 2023

Cureus

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Objective: Our aim in this study was to evaluate the level of central sensitization (CS) in patients having familial Mediterranean fever (FMF), axial spondyloarthritis (axSpA), and both diseases (axSpA/FMF). Methods: This study included 30 FMF, 30 axSpA, 30 axSpA/FMF patients, and 30 healthy controls (HCs). The presence of CS was investigated by the Central Sensitization Inventory (CSI) questionnaire. In order to evaluate the effect of CS on patient groups, clinical features, disease activity, quality of life, sleep quality, depression, and anxiety frequency were examined. The patients were divided into groups according to the presence and severity of CS and their results were compared. Results: The mean age of all participants was 28.4±5.7 years and 67 (55.8%) of them were male. The erythrocyte sedimentation rate (ESR) value was significantly higher in axSpA and axSpA/FMF groups than in FMF and HCs groups (p<0.001). ESR value was significantly higher in the FMF group than in the HCs group (p<0.001). C-reactive protein (CRP) value was significantly higher in the axSpA/FMF group than in the axSpA and HCs groups (p=0.001). CSI-Part A value was significantly higher in the axSpA, FMF, and axSpA/FMF group than in the HCs group (p<0.001). CSI-Part A value did not differ significantly between axSpA/FMF, axSpA, and FMF groups (p>0.05). The presence of chronic fatigue syndrome was found to be significantly higher in the FMF group than in the axSpA and HCs groups (p<0.05). Fibromyalgia syndrome was significantly higher in the axSpA/FMF group than in the axSpA, FMF, and HCs groups (p<0.05). Conclusions: In this study, the CS score was found to be significantly higher in axSpA and FMF patients compared to the HCs group. There was no difference between the disease groups in terms of CS score.

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The relation of psychological status and type D personality with central sensitization in knee osteoarthritis: everything is in your mind!

Sariyildiz,

Coskun Benlidayi,

Olmez Engizek

et al. 2023

Rheumatol Int

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Clinical and functional impact of central sensitization on patients with familial Mediterranean fever: a cross-sectional study

Cited by 6 publications

References 44 publications

Biopsychosocial factors should be considered when evaluating central sensitization in axial spondyloarthritis

Biopsychosocial factors should be considered when evaluating central sensitization in axial spondyloarthritis

Effect of Central Sensitization in Patients with Familial Mediterranean Fever, Axial Spondyloarthritis, and Both Diseases

The relation of psychological status and type D personality with central sensitization in knee osteoarthritis: everything is in your mind!

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