Clinical and forensic signs related to ethanol abuse: a mechanistic approach

Dinis-Oliveira, Ricardo Jorge; Magalhães, Teresa; Moreira, Roxana; Proença, Jorge Brandão; Pontes, Helena; Santos, Agostinho; Duarte, José Alberto; Carvalho, Félix

doi:10.3109/15376516.2013.869782

Cited by 22 publications

(12 citation statements)

References 281 publications

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“…In contrast to previous studies, we did not find associations for other determinants, including smoking, alcohol and education (Table ). None of these previous studies adjusted for the important seborrhoeic dermatitis predictors such as sex, age or skin colour, leading to residual confounding and spurious associations, especially because differences in smoking and alcohol consumption between men and women are well known .…”

Section: Discussioncontrasting

confidence: 99%

“…those with a decreased barrier function), is causal in the development of seborrhoeic dermatitis . Several other determinants have been studied as well, including older age, male sex, obesity, skin colour, stress, depression, winter climate, alcohol consumption, tobacco exposure, hypertension, HIV and Parkinson disease . However, some of these studies were small (less than 100 participants), or conducted in a selected population (e.g.…”

mentioning

confidence: 99%

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Prevalence and determinants of seborrhoeic dermatitis in a middle‐aged and elderly population: the Rotterdam Study

et al. 2017

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SummaryBackground Seborrhoeic dermatitis is a chronic relapsing inflammatory skin disease with unclear pathophysiological mechanisms. Objectives To establish which lifestyle and physiological determinants are associated with seborrhoeic dermatitis. Methods Seborrhoeic dermatitis was diagnosed by a trained physician during a full-body skin examination within the Rotterdam Study, a prospective population-based cohort study in middle-aged and elderly people. The current design is a comparative cross-sectional study embedded in the Rotterdam Study. Potential factors were identified from the literature and analysed in a multivariable logistic regression, including: age, sex, obesity, skin colour, stress, depression, education level, hypertension, climate, xerosis cutis, alcohol and tobacco use. Results Of the 5498 participants, 788 participants were diagnosed with seborrhoeic dermatitis (14Á3%). We found associations between seborrhoeic dermatitis and male sex [adjusted odds ratio (OR) 2Á09, 95% confidence interval (CI) 1Á77-2Á47], darker skin (adjusted OR 0Á39, 95% CI 0Á22-0Á69), season (summer vs. winter: adjusted OR 0Á63, 95% CI 0Á48-0Á82) and generalized xerosis cutis (adjusted OR 1Á41, 95% CI 1Á11-1Á80). Conclusions Seborrhoeic dermatitis is one of the most common inflammatory dermatoses in middle-aged and elderly individuals, especially during winter. Men, and people with a light and dry skin were most likely to have seborrhoeic dermatitis.

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Section: Discussioncontrasting

confidence: 99%

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confidence: 99%

Prevalence and determinants of seborrhoeic dermatitis in a middle‐aged and elderly population: the Rotterdam Study

et al. 2017

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“…Epidemiological and experimental studies have documented that heavy ethanol consumption causes more than 60 types of diseases and is, in a dose-dependent manner, a contributing cause to a large number of other medical conditions [3, 4, 7, 9, 17, 38, 39]. Several studies have provided a wealth of data linking heavy ethanol consumption to the development of hypertension [4-13].…”

Section: Discussionmentioning

confidence: 99%

Heavy Alcohol Consumption Effects on Blood Pressure and on Kidney Structure Persist After Long-Term Withdrawal

Leal

Jorge

Barbosa

et al. 2017

Kidney Blood Press Res

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Background/Aims: Heavy ethanol consumption is a risk factor for hypertension and prompts organ damage. There is no information regarding the impact of long-term heavy ethanol consumption on kidney structure and function linking to their hypertensive effects nor the repercussions after withdrawal. Methods: Rats were exposed to ethanol for 24 weeks and, afterwards, a group was assigned to withdrawal for 8 weeks. Blood pressure (BP) was measured and serum biochemical parameters were quantified. Glomerular volume density, areal density of glomerular tuft and renal corpuscles were determined. Angiotensin II type 1 receptor (AT1R) protein expression was evaluated. Results: Twenty-four weeks of ethanol consumption causes atrophy of renal corpuscles and glomeruli and reduces the volume of glomeruli. Glomerular changes induced by ethanol consumption were still evident after withdrawal. Renal AT1R levels were increased in ethanol-treated rats and returned to control levels during withdrawal. Ethanol consumption also induced an increase in BP, uric acid and albumin levels. Upon withdrawal, systolic and mean arterial pressures decreased, but were still higher than in controls rats. Conclusion: Ethanol consumption induces changes in glomerular morphology associated with increased BP and AT1R expression. Long-term withdrawal was inefficient to restore the structural integrity of renal corpuscles and in lowering systolic pressure.

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“…In children whose mothers drank alcohol there are functional difficulties that are difficult to diagnose and classify, and often sensory integration dysfunction. For these children SI therapy is necessary and effective [10][11][12][13][14][15][16][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]. This work, because of the breadth of statistical analysis, only shows the effects of SI therapy on gross motor function.…”

Section: Discussionmentioning

confidence: 99%

The impact of sensory integration therapy on gross motor function in children after prenatal exposure to alcohol

Wilczyński¹,

Zawada²

2015

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Słowa kluczowe: fizjoterapia, integracja sensoryczna, dzieci po prenatalnej ekspozycji na alkohol. AbstractIntroduction: In Poland there are 900 cases of full-blown foetal alcohol syndrome (FAS) in neonates per year, and in 9000 children there are some symptoms of it. Aim of the research: To analyse the impact of sensory integration (SI) therapy on gross motor skills function in children after prenatal exposure to alcohol. Material and methods: The study was conducted on a group of 20 children aged 4-5 years with information from an interview about prenatal exposure to alcohol. The diagnosis of sensory integration disorder consisted of two 60-minute diagnostics meetings. Twelve trials with clinical observations were performed by Ayres: finger to nose, cocontraction, prone extension posture, flexed position supine, asymmetrical tonic neck reflex (ATOS), symmetrical tonic neck reflex (STOS), muscle tension, Schilder test, dynamic balance, static balance, gravitational insecurity, and trunk stabilisation. The therapeutic program included: normalisation of the vestibular and proprioceptive system, normalisation of the touch system, strengthening muscle tension, development of motion planning, development of oculomotor performance, development of motor coordination, hand therapy, integration of ATOS, STOS, development of locomotion and balance functions, and improving efficiency of gross and small motor skills. Results and conclusions: High efficiency of SI therapy has been shown in children after prenatal exposure to alcohol on the example of gross motor skills. Positive effects of SI therapy have been shown for tests: finger to nose, in the erect position on the stomach, the flexural position on the back, ATOS, STOS, Schilder test, dynamic balance, static balance, and the uncertainty of gravity and trunk stabilisation. Only cocontraction and muscle tension tests showed no efficacy of SI therapy. The a-Cronbach position analysis showed high reliability of the performed tests both before and after the therapy. It is advisable to continue the study on a larger sample and observation of the functional status of children after therapy.

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Clinical and forensic signs related to ethanol abuse: a mechanistic approach

Cited by 22 publications

References 281 publications

Prevalence and determinants of seborrhoeic dermatitis in a middle‐aged and elderly population: the Rotterdam Study

Prevalence and determinants of seborrhoeic dermatitis in a middle‐aged and elderly population: the Rotterdam Study

Heavy Alcohol Consumption Effects on Blood Pressure and on Kidney Structure Persist After Long-Term Withdrawal

The impact of sensory integration therapy on gross motor function in children after prenatal exposure to alcohol

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