Clinical and experimental substantiation of the effect of hypoxia on the wall of the small and large intestine in newborns

Karpova, Irina Yuryevna; Паршиков, В. В.; Prodanets, N.N.; Solovieva, Tatyana Ivanovna; Pyatova, Evgenia Dmitrievna; Молчанова, Д. В.; Бебенина, А. А.

doi:10.18499/2070-478x-2018-11-4-268-274

Cited by 2 publications

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“…Тихоновой и соавт. [41] при проведении окклюзии сосудов брыжеечной аркады дистального отдела подвздошной кишки у маловесных поросят в течение 48 ч морфологическая картина характеризовалась широким диапазоном изменений: от минимальных в виде эрозий слизистой оболочки и десквамации единичных эпителиальных клеток, до выраженных -с некрозом стенки, пневмотозом, перфорацией и развитием перитонита. При окклюзии только лимфатических сосудов морфологическая картина НЭК отмечалась лишь у особей с очень низкой массой тела, а при окклюзии только артерий морфологическая картина отличалась отсутствием пневматоза стенки кишки.…”

Section: использование свиней для моделирования нэк в эксперименте In...unclassified

Experimental modeling of necrotic enterocolitis: A review

Severinov,

Lipatov,

Gavrilyuk

et al. 2023

Russian Journal of Pediatric Surgery, Anesthesia and Intensive

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Neonatal necrotizing enterocolitis (NEC) is a multifactorial disease of unspecified etiology. The lack of data on etiological factors and the complexity of pathogenetic mechanisms determine the complexity of NEC modeling. The authors involved in the study of the pathogenesis of NEC and the development of current treatments seek to model in the experiment the conditions that occur in clinical practice. Thus, this study aimed to analyze the options for the experimental modeling of neonatal NECs described in the public domain. Thus, more than 50 relevant scientific publications in databases such as Google Scholar, PubMed, Scopus (publishers Elsevier), and eLibrary (from 2000 to 2022) were reviewed. This paper describes the most current methods of modeling NEC, including in vitro (using cells and cell cultures), in vivo (in laboratory animals such as mice, rats, rabbits, and pigs), and ex vivo (using cadaver material) experiments.

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Section: использование свиней для моделирования нэк в эксперименте In...unclassified

Experimental modeling of necrotic enterocolitis: A review

Severinov,

Lipatov,

Gavrilyuk

et al. 2023

Russian Journal of Pediatric Surgery, Anesthesia and Intensive

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Posthypoxic Changes in Rat Offspring under the Intestinal Wall Transformation

Karpova

Bugrova

Vasyagina

et al. 2021

VECS

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The aim of research is to study posthypoxic transformation of the colon wall using light and electron microscopy in an experimental model of rat offspring. Materials and methods. Chronic hypobaric hypoxia at different stages of pregnancy was simulated experimentally in 24 female white mongrel rats using a vacuum flow chamber with a rise to a height of 5000 m at a speed of 25 m/sec for 40 minutes. After delivery, the offspring were examined, subjected to hexenal anesthesia, and then removed from the experiment using decapitation. For light microscopy, resected sections of the small intestine and colon were stained with hematoxylin-eosin, and studied on Topic (Belgium, 2000) and Bio Blue (the Netherlands, 2013). Electron microscopic analysis was performed in a Morgagni 268D transmission electron microscope (FEI, USA). Results. Chronic hypoxia, simulated in the first trimester of pregnancy, led to significant changes in the intestinal mucosa in combination with the growth of the connective tissue component in the muscle layer. The risk of developing dynamic intestinal obstruction occurred in the offspring of all groups, this was supported by an increase in the fibrous tissue of the intestinal wall. Pronounced changes in the microcirculatory bed were detected in animals of groups II and III, as they were predisposed to develop pre-ulcer and ulcerative defects in the wall of the small intestine. At the submicroscopic level, it was detected that both adaptive and destructive processes occurred in the wall ultrastructure of the descending colon of the rat offspring after hypoxic exposure in the prenatal period in animals of all experimental groups. In the microcirculatory bed, there was an increased venous congestion, with the most pronounced changes observed in the third trimester. Conclusion. Thus, the study of hypoxia in the experiment allows investigating more about all the mechanisms of the pathological process and to translate theoretical knowledge into practical medicine.

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Clinical and experimental substantiation of the effect of hypoxia on the wall of the small and large intestine in newborns

Cited by 2 publications

References 0 publications

Experimental modeling of necrotic enterocolitis: A review

Experimental modeling of necrotic enterocolitis: A review

Posthypoxic Changes in Rat Offspring under the Intestinal Wall Transformation

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