Clinical and experimental study on treatment of Psoriasis Maculata by Leyin

Abstract

Objective: To observe the therapeutic effect of Leyin (~, LY) in treating psoriasis maculata (PM) and its effects on cellular immunity and vaginal epithelial cell mitosis in experimental mice. Methods: In this clinical study, 260 out-patients of PM were randomly divided into the observed group (n = 160) and the control group (n= 100), who were treated with oral intake of LY and Yinxieling granule (YXL, /~,l~,~ilJ) respectively to observe the therapeutic effect and the adverse reaction. And a followup study was also conducted on them. In the experimental study, delayed allergic model mice were treated with immunosuppressor(cyclophosphamide) and LY separately to observe the effects on their immune function and inhibition of vaginal epithelial cell proliferation. Results: In the observed group, 8 patients (5%) were cured, 32 (20~) basically cured, 48 (30~) markedly improved, 48 (30~) improved and 24 (15 ~) unchanged, the total effective rate being 85 ~, while in the control group, the corresponding numbers were 4, 8, 14, 38, 36 and 64~ respectively, with the comparison of the total effective rate between the two groups showing significant difference(P%0.01). Adverse reactions were not found in the study. Experimental study showed that LY could enhance the immune function of mice and had a certain inhibitory effect on vaginal epithelial cell proliferation. Conclusion: LY could treat PM effectively and shows immune enhancing and anti-mitosis effect in mice. KEY WORDS Leyin, macular psoriasis, cellular immunity, mice * This article is supported by the fund of Integrated Chinese Traditional and Western Medicine from Health Bureau of Tianjin City (No. 98012)