Clinical and Experimental Observations on the Significance of Endotoxemia

Kass, Edward H.; Porter, P.; McGill, Michael W.; Vivaldi, E

doi:10.1093/infdis/128.supplement_1.s299

Cited by 16 publications

(5 citation statements)

References 3 publications

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“…3) a sigmoid curve is obtained which shows that a relative uptake of 17.5% is associated with 100% mortality. Similar results were obtained in rabbits by Kass et al [22]. These differences in mortality can be attributed to the different techniques used.…”

Section: Discussionsupporting

confidence: 86%

Experimental hemorrhagic shock in dogs: Standardization

1983

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The purpose of the present study was to design a standardized model of hemorrhagic shock in dogs as a prerequisite for future studies on the pathogenesis of this syndrome. Hemorrhagic shock was induced in 86 mongrel dogs submitted to a systemic hypotension of 45 mm Hg by means of a constant pressure reservoir procedure. The following blood volumes (ml/kg) were measured during the evolution of shock: (1) initial bleeding volume, (2) secondary bleeding volume, (3) maximum bleeding volume, (4) automatic reinfusion volume, and (5) duration of the hypotensive period (min). The corresponding mortalities were submitted to a statistical analysis which yielded the following conclusions: (a) the initial, secondary, and maximum bleeding volumes do not correlate with mortality, (b) the duration of the hypotensive period is of only relative importance, and (c) the automatic reinfusion volumes shows a high degree correlation with the fatal outcome.

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Section: Discussionsupporting

confidence: 86%

Experimental hemorrhagic shock in dogs: Standardization

1983

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“…'Suprarenal apoplexy' (Waterhouse, 1911) is an unlikely cause of death as shown by the high cortisol levels, clinical findings, and ineffectiveness of corticosteroid treatment. Endotoxaemia as detected in our patients was also of no prognostic significance; perhaps the Limulus test lacks clinical value (Stumacher et al, 1973), or endotoxin is not the central issue after all (Kass et al, 1973).…”

Section: Discussionmentioning

confidence: 56%

Prognostic factors in acute meningococcaemia.

Lewis¹

1979

Archives of Disease in Childhood

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SUMMARY During a meningococcal (group A) epidemic, 47 Nigerian children with acute meningococcaemia without meningitis were studied. Their mortality rate was 43 % compared with 8 % during the whole epidemic. Those presenting with coma and shock had a mortality of 93 %, but without shock or coma mortality was only 6%. Coma or shock occurring alone carried an intermediate prognosis. The outcome correlated with initial serum antigen titre, but not with the serum levels of endotoxin, cortisol, or fibrin degradation products. Chloramphenicol was as effective as penicillin. A predictor of expected mortality, based on serum antigen titre and the presence of coma or shock, may allow new forms of treatment to be assessed.

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“…The cell wall of gram-negative bacteria consists largely of a lipopolysaccharide (LPS) known as endotoxin (21). Its multiple effects on the higher organisms have been extensively studied (15,16). One of the properties of LPS is its mitogenicity for B-lymphocytes (2,3,9,29,34,36).…”

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confidence: 99%

Mitogenic stimulation of murine spleen cells: relation to susceptibility to Salmonella infection

Jeney¹,

Günther²,

Jann³

1977

Infect Immun

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The screening of several inbred strains of mice suggested that the capacity of their spleen cells to respond to the mitogenic effect of lipopolysaccharide (LPS) of gram-negative bacteria was correlated with their resistance to intraperitoneal infection with Salmonella typhimurium. An injection of LPS into mice caused changes in the in vitro responsiveness of their spleen cells to the mitogenic effects of LPS and phytohemagglutinin. Pretreatment of mice with whole ultraviolet (UV)-killed bacteria led to a marked rise in the in vitro response of the spleen cells to UV-killed bacteria, but not to LPS or phytohemagglutinin. This enhanced response to UV-killed bacteria was not specific for the 0 antigens of the bacteria.

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Clinical and Experimental Observations on the Significance of Endotoxemia

Cited by 16 publications

References 3 publications

Experimental hemorrhagic shock in dogs: Standardization

Experimental hemorrhagic shock in dogs: Standardization

Prognostic factors in acute meningococcaemia.

Mitogenic stimulation of murine spleen cells: relation to susceptibility to Salmonella infection

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