Clinical and Epidemiological Study of Disease Caused by Mycobacterium kansasii in the Metropolitan Area of Bilbao, Spain

Arranz, M.; Gaafar, Ayman; Barañano, Miren Josebe Unzaga; Notario, J.; Cáncer, R. Cisterna; Cebrián, F. García

doi:10.1016/s1579-2129(06)60424-2

Cited by 7 publications

(6 citation statements)

References 24 publications

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“…In most places, M. kansasii ranks second, behind only Mycobacterium avium complex, as a cause of NTM lung disease [8]. The annual rates of infection due to M. kansasii reported in the general population fall within the range of 0.2 to 0.3 cases per 100 000 [4], yet significant geographical variability exists [9–12]. In Poland, among the cases of NTM disease, whose number has been increasing remarkably in recent years, those attributable to M. kansasii are in the majority [13].…”

Section: Introductionmentioning

confidence: 99%

Short Communication: Subtyping ofMycobacterium kansasiiby PCR-Restriction Enzyme Analysis of thehsp65Gene

Bakuła

Safianowska

Nowacka-Mazurek

et al. 2013

BioMed Research International

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Mycobacterium kansasii is one of the most common causes of pulmonary disease resulting from nontuberculous mycobacteria (NTM). It is also the most frequently isolated NTM species from clinical specimens in Poland. The aim of this study was to investigate the distribution of M. kansasii subtypes among patients suspected of having pulmonary NTM disease. Fifty clinical isolates of M. kansasii recovered from as many patients with suspected mycobacterial lung disease between 2000 and 2010 in Poland were genotyped by PCR-restriction enzyme analysis (PCR-REA) of partial hsp65 gene. Mycobacterium kansasii subtype I was the only genotype to be identified among the isolates, both disease-associated and non-disease-associated. Isolation of M. kansasii subtype I from clinical specimens may be indicative of infection but may also merely represent colonization.

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Section: Introductionmentioning

confidence: 99%

Short Communication: Subtyping ofMycobacterium kansasiiby PCR-Restriction Enzyme Analysis of thehsp65Gene

Bakuła

Safianowska

Nowacka-Mazurek

et al. 2013

BioMed Research International

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“…Our patient presented with many of these features: fevers, night sweats, and myalgias. Extrapulmonary disease is rare, with rates ranging between 0.6% and 9% . M. kansasii is thought to be one of the most pathogenic NTM .…”

Section: Discussionmentioning

confidence: 99%

Chronic laryngitis caused by Mycobacterium Kansasii in a traveler

et al. 2019

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Chronic laryngitis commonly presents with dysphonia, and infectious causes include tuberculosis and endemic mycoses. We present a 58-year-old female with laryngitis for 5 years, fevers, chills, fatigue, malaise, myalgias, anterior neck pain, and night sweats after multicontinent exposure. Bronchoscopy cultures were negative. Bilateral microflap excision of vocal fold lesions demonstrated thickened epithelium and a deep vocal fold mass. Biopsy showed necrotizing granulomatous inflammation with acid-fast bacilli. Mycobacterium kansasii was identified. Treatment led to improvement in dysphonia, systemic symptoms, and vocal fold irritation. To our knowledge, this is the first case of isolated nontuberculous mycobacterial vocal fold infection.

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“…The disease was more frequent in male patients, individuals who were HIV negative, and in urban areas. Nowadays, although M. kansasii is the second mycobacteria isolated in Bizkaia after M. tuberculosis, the number of isolations has decreased very significantly [2][3][4]. The natural reservoirs of non-primary pathogenic mycobacteria include aquatic and terrestrial environments.…”

Section: Discussionmentioning

confidence: 99%

“…Large regional differences have been detected in the incidence of M. kansasii infection. In Spain, M. kansasii is the NTM that causes pulmonary disease most frequently; in some series, M. kansasii caused up to 4% of all mycobacterial infections [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

A Case of Severe Mycobacterium kansasii Infection Complicated with the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)

Caceda¹,

Garros²,

Unzaga³

et al. 2015

Mycobact Dis

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We present a case of severe Mycobacterium kansasii infection due to the clinical and radiological progression and complicated with syndrome of inappropriate antidiuretic hormone secretion (SIADH). This 54-year-old male alcoholic and heavy smoker as predisposing factors presented severe anorexia, asthenia and cachexia. Abundant acid-fast bacilli (AFB) were observed in the patient's sputum and pleural fluid after Ziehl-Neelsen (ZN) staining. The strain was identified as M. kansasii by culture. A treatment with isoniazid, pyrazinamide, ethambutol, clarithromycin and moxifloxacin were then initiated. The course of the illness includes impaired consciousness, behavioural disturbances and agitation; we believe was a consequence of SIADH, because of the severe hyponatremia with low serum osmolality condition. Also, generalized or local infections are important and unregarded causes of SIADH. Multiple infectious diseases are associated with this syndrome [1]. An awareness of this pathogen with clinical, radiologic, and microbiologic parameters are all needed to establish the diagnosis of this infection and the eradication of disease requires prolonged combination drug therapy.

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Clinical and Epidemiological Study of Disease Caused by Mycobacterium kansasii in the Metropolitan Area of Bilbao, Spain

Cited by 7 publications

References 24 publications

Short Communication: Subtyping ofMycobacterium kansasiiby PCR-Restriction Enzyme Analysis of thehsp65Gene

Short Communication: Subtyping ofMycobacterium kansasiiby PCR-Restriction Enzyme Analysis of thehsp65Gene

Chronic laryngitis caused by Mycobacterium Kansasii in a traveler

A Case of Severe Mycobacterium kansasii Infection Complicated with the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)

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