Clinical and epidemiological characteristics of a patient infected with H5N6 avian influenza A virus

Li, Kuibiao; Liu, Hui; Yang, Zhicong; Li, Tiegang; Di, Biao; Chen, Zongqiu; Lu, Jianyun; Chen, Guangyan; Zhao, Ping; Yang, Lei; Su, Wenzhe; Xiao, Xue; Luo, Lei; Li, Weiqiang; Lin, Chuangming; Li, Gongli; Mei, Xiaoqing; Tang, Xiaoping; Wang, Ming; Zheng, Bo‐Jian

doi:10.1016/j.jcv.2016.06.004

Cited by 8 publications

(7 citation statements)

References 10 publications

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“…1,2 Migratory birds play an important role in the occurrence of avian influenza A viruses in domestic poultry, thus, various subtypes of HPAI have spread in Asian countries including China, Vietnam, Laos, Japan, and Republic of Korea. 3 Because poultry-human transmission of HPAI H5 is likely to occur by direct contact with infected poultry, 1,4,5 early detection and depopulation of infected poultry flocks are commonly used to control the spread of HPAI virus in poultry and to prevent human infections. 6 Starting November 20, 2016, poultry infections by HPAI (H5N6) virus were reported in Gyeonggi Province, Republic of Korea.…”

Section: Introductionmentioning

confidence: 99%

Low risk of avian influenza A (H5N6) transmission to depopulation workers in Korea

Ryu

Lim

Cowling

et al. 2018

Influenza Resp Viruses

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An outbreak of highly pathogenic avian influenza A (H5N6) virus occurred between November 20, 2016, and March 1, 2017 in poultry farms, in the Gyeonggi Province, Republic of Korea. To identify the risk of transmission of H5N6 to depopulation workers, active and passive surveillance was conducted. Virological testing of respiratory swabs with real‐time reverse transcription‐polymerase chain reaction was performed for workers who reported respiratory symptoms. Among 4633 depopulation workers, 22 reported respiratory symptoms, but all tested negative for H5N6. Personal protective equipment in addition to antiviral prophylaxis was adequate to limit transmission of H5N6 from poultry to humans.

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Section: Introductionmentioning

confidence: 99%

Low risk of avian influenza A (H5N6) transmission to depopulation workers in Korea

Ryu

Lim

Cowling

et al. 2018

Influenza Resp Viruses

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“…Improvement in survival was observed among H5N1 infected patients treated with oseltamivir compared to those without treatment [29,30]. More recent zoonotic HPAIV H5N6 strains have been shown susceptible to NAIs [31,32]. In contrast, more recent HPAIV H5N8 has shown reduced susceptibility to NAIs [33–35].…”

Section: Fda Approved Antiviralsmentioning

confidence: 99%

Influenza antivirals and animal models

et al. 2022

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Influenza A and B viruses are among the most prominent human respiratory pathogens. About 3–5 million severe cases of influenza are associated with 300 000–650 000 deaths per year globally. Antivirals effective at reducing morbidity and mortality are part of the first line of defense against influenza. FDA‐approved antiviral drugs currently include adamantanes (rimantadine and amantadine), neuraminidase inhibitors (NAI; peramivir, zanamivir, and oseltamivir), and the PA endonuclease inhibitor (baloxavir). Mutations associated with antiviral resistance are common and highlight the need for further improvement and development of novel anti‐influenza drugs. A summary is provided for the current knowledge of the approved influenza antivirals and antivirals strategies under evaluation in clinical trials. Preclinical evaluations of novel compounds effective against influenza in different animal models are also discussed.

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“…There have also been small-scale epidemics, such as the avian influenza virus A (H5N1) outbreak in Hong Kong in 1997, in which 18 individuals were infected and 6 died (WHO 2004). In addition to the avian influenza virus A H5N1, highly pathogenic avian influenza virus A H5N2 (Yang et al 2015; Zhan et al 2012), avian influenza virus A H5N5 (Gu et al 2011), H5N6 (Li et al 2016; Qi et al 2014), H5N8 (Wang et al 2016; Zhao et al 2013), and H5N9 (Yu et al 2015) have also been isolated or confirmed from avian, mice, dog, or humans in China since 2000. It is noteworthy that the first human avian influenza A H5N6 infections were reported in Sichuan province (Nations and F.a.A.O.o.t.U.…”

Section: Introductionmentioning

confidence: 99%

Genotyping and detection of common avian and human origin-influenza viruses using a portable chemiluminescence imaging microarray

et al. 2016

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Background Influenza viruses are divided into three types, A, B, and C. Human influenza A and B viruses can cause seasonal epidemics, but influenza C causes only a mild respiratory illness. Influenza A virus can infect various host species. In 2013, human-infectious avian influenza A (H7N9) was first reported in China. By the second week of 2014, there were 210 laboratory-confirmed human cases in the country, and the mortality rate eventually reached 22 %. Rapid and accurate diagnosis of influenza viruses is important for clinical management and epidemiology. MethodsIn this assay, a cost-effective chemiluminescence (CL) detection oligonucleotide microarray was developed to genotype and detect avian influenza A (H7N9), avian influenza A (H5N1), 2009 influenza A (H1N1), seasonal influenza A (H1N1), and seasonal influenza A (H3N2). Influenza A viruses and influenza B viruses were also generally detected using this microarray.ResultsThe results of detection of 40 cultivated influenza virus strains showed that the microarray was able to distinguish the subtypes of these influenza viruses very well. The microarray possessed similar or 10 fold higher limit of detection than the real-time RT-PCR method. Sixty-six clinical swab samples were detected using this microarray and verified with real time RT-PCR to evaluate the efficiency of this microarray for clinical testing.ConclusionsA reliable CL detection oligonucleotide microarray had been developed to genotype and detected these influenza viruses.

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Clinical and epidemiological characteristics of a patient infected with H5N6 avian influenza A virus

Cited by 8 publications

References 10 publications

Low risk of avian influenza A (H5N6) transmission to depopulation workers in Korea

Low risk of avian influenza A (H5N6) transmission to depopulation workers in Korea

Influenza antivirals and animal models

Genotyping and detection of common avian and human origin-influenza viruses using a portable chemiluminescence imaging microarray

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