Clinical and epidemiological characteristics of Chagas disease in an endemic area of Sergipe State, Brazil

Glass, Ivani Rodrigues; Santos, Allan Dantas dos; Varjão, Ana Elisabeth Leal; Costa, Isabela Soares; Correia, Dalmo; Silva, Angela Maria

doi:10.1590/0037-8682-0067-2018

Cited by 7 publications

(10 citation statements)

References 9 publications

(9 reference statements)

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“…Most patients recalled having been bitten by the triatomine bug, reinforcing the hypothesis of infection via vector transmission. These findings were similar to those published by others 20 .…”

Section: Discussionsupporting

confidence: 93%

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Epidemiological features, echocardiographic findings, and parasite load in patients with Chagas disease

Arruda

Ribeiro

Silva

et al. 2019

Rev. Soc. Bras. Med. Trop.

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Introduction: Chagas disease is a major public health problem that is endemic in Brazil and Latin America. This study aimed to determine the socioeconomic, demographic, and clinical characteristics of 171 patients (mean age, 45 years; female, 65%) with Chagas disease at Hospital Universitário de Brasília, Federal District, Brazil. Methods: We implemented this cross-sectional study using a clinical epidemiological questionnaire, electrocardiography, echocardiography, and quantitative detection of Trypanosoma cruzi DNA in blood using qRT-PCR. Results: Among the patients, 26.3% had a full elementary education, and 13.2% were illiterate. Most (63.6%) were economically classified as class C, and 51.5% were born in Bahia state. A total of 62.0% participants reported previous contact with the triatomine bug. The clinical forms of the disease were indeterminate (69.51%), cardiac (15.24%), digestive (10.37%), and mixed (4.88%). The most common electrocardiographic abnormality was complete right bundle branch block in association with a divisional anterosuperior block. Only 14.6% of the patients complied with benznidazole medication for at least 60 days, and 164 of them were assessed by echocardiography. The parasite load was positive in 56% of the patients. Conclusions: Chagas disease affected mostly women, with the indeterminate chronic form of the disease.

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Section: Discussionsupporting

confidence: 93%

“…Our patients had an average education duration of four years, and were thus better educated than those in previous studies ( Table 1) 19,20 .…”

Section: Discussionmentioning

confidence: 65%

Epidemiological features, echocardiographic findings, and parasite load in patients with Chagas disease

Arruda

Ribeiro

Silva

et al. 2019

Rev. Soc. Bras. Med. Trop.

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“…With their own expertise, they contributed from the initial conception of the project, helped to choose Minas Gerais cities and changed project identification from CE XXI to CE21. Low level of education is a general profile of CD seropositive individuals [56][57][58], as observed in the present study. Most CD affected persons have a low income, and restricted access to education opportunities.…”

Section: Chagas Disease Affected Persons As Main Actors In Chagas Express XXIsupporting

confidence: 85%

“Chagas Express XXI”: A new ArtScience social technology for health and science education—A case study in Brazilian endemic areas of Chagas disease with an active search of chronic cases

et al. 2021

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Background Chagas Disease (CD) affects 6–7 million people worldwide and is related to poverty-promoting conditions. Chronic asymptomatic cases are mostly invisible to health systems. Aiming (1) to translate CD discoveries into education/information practices to raise alertness and empowerment of affected people; and (2) to perform an active search of CD cases, articulating intersectoral actions to improve the access of infected people to the local health service for the treatment of CD; our research group developed and tested under field conditions as innovative social technology: an itinerant education interdisciplinary setting named “Chagas Express XXI” (CE21). Methodology CE21 was created as an “imaginary train” with ~40 ArtScience workshops, games, laboratory activities and conversation circles. An entry/exit plus six activity modules combined associations of affected people, microscopic observations, One Health education, and wellness activities. CE21 was conceived as a social technology, since all the processes were co-created with CD patients and inter-sector local partners. Descriptive statistics showed quantitative data collected throughout the expeditions (CD knowledge, serological results). Qualitative data accessed the public perceptions about the education activities. Principal findings CE21 was exhibited in local educational institutions (schools, universities) in four cities, engaging 2,117 people that evaluated the 41 activities carried out. Citizens and health professionals enjoyed acquisition of information related to blood, parasites, vectors, reservoirs, environmental changes, and social determinants of CD. Further, local legacies of 600 participants volunteer for health promotion groups and CD associations, local empowerment groups to fight for better health conditions, and 05 mural paintings. We observed that 81% of the participants ignored the possibility of treating CD while 52% of the participants requested a blood test for CD showing seropositivity in 20% of them. Conclusions CE21 is a social technology potentially useful for health and science education and active search of asymptomatic CD chronic cases. Moreover, this technology may be adapted to understand and to cooperate in other potentially epidemic situations, especially NTDs related.

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“…Most municipalities are in rural areas, with unhealthy housing, inadequate basic sanitation and mud huts, all of which facilitate the reproduction and maintenance of triatomines. A pilot study in 2016 showed 12.1% of seropositivity for T. cruzi infection in the city of Umba uba [8].…”

Section: Discussionmentioning

confidence: 99%

“…With a rate of 5.0%, Brazil's southeastern and northeastern regions have the highest prevalence of the disease [6, 7]. The state of Sergipe has some municipalities at high risk for the transmission of Chagas infection [8]. However, the spatial dynamics and the delimitation of potential risk areas for mortality due to CD are not known, and analyses of the various factors associated with the occurrence of CD and related mortality are needed that take into consideration socio‐environmental and economic aspects.…”

Section: Introductionmentioning

confidence: 99%

Spatial patterns and temporal tendency of mortality related to Chagas disease in an endemic area of northeastern Brazil

Góes

Andrade

Carvalho

et al. 2020

Tropical Med Int Health

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objective To analyse spatial patterns and the temporal tendency of mortality related to Chagas disease, in order to identify priority control areas in the state of Sergipe, Northeast Brazil. methods We conducted an ecological and time-series study with spatial analysis techniques on deaths from Chagas disease in the state of Sergipe (1996-2016). We used data from the Mortality Information System (SIM). The temporal analysis was performed using a statistical technique capable of describing changes in the trend pattern for the period. Thematic maps were elaborated from point and polygonal analyses. results There were 247 deaths related to Chagas disease, with a mean of 11.7 deaths/year, most of them male (64%), and aged 50-59 years (21%) and 60-69 years (26%). Two segments with increasing, non-constant and significant trends were identified: 1996-2005 (APC = 21.6%; P = 0.01) and 2005-2016 (APC = 4.4%; P = 0.01), with APPC = 11.8% (P = 0.01). A positive and significant spatial autocorrelation with areas of higher risk of death was found in the southern region of the state. conclusions The trend of mortality related to Chagas disease in the state of Sergipe was increasing during the period analysed, with a heterogeneous distribution of cases. A main risk area was identified in the southern region of the state.

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Clinical and epidemiological characteristics of Chagas disease in an endemic area of Sergipe State, Brazil

Cited by 7 publications

References 9 publications

Epidemiological features, echocardiographic findings, and parasite load in patients with Chagas disease

Epidemiological features, echocardiographic findings, and parasite load in patients with Chagas disease

“Chagas Express XXI”: A new ArtScience social technology for health and science education—A case study in Brazilian endemic areas of Chagas disease with an active search of chronic cases

Spatial patterns and temporal tendency of mortality related to Chagas disease in an endemic area of northeastern Brazil

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