Clinical and epidemiological aspects related to the detection of adenovirus or respiratory syncytial virus in infants hospitalized for acute lower respiratory tract infection

Ferone, Eduardo A.; Berezin, Eitan N.; Durigon, Giuliana Stravinskas; Finelli, Cristiane; Felício, Maria C.C.; Storni, Juliana Gamo; Durigon, Edison L.; Oliveira, Danielle Bruna Leal

doi:10.1016/j.jpedp.2013.05.004

Cited by 6 publications

(12 citation statements)

References 25 publications

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“…During the study period, viral infections were detected in 78.1% of the cases of ALRI, with the lowest positive rate in the third season (p < 0.05). In the PCRbased surveys conducted in various countries, the percentages of proven viral infections in cases of ALRI varied greatly, i.e., 83.2% in China [17], 75.2% in Spain [18], 50.3% in Brazil [19], and 36.7% in Turkey [20], due to differences in climatic and geographic conditions, the study population, and the range of respiratory agents investigated. In our population, the proportion of viral infections in the cases of bronchiolitis and pneumonia was 82.6% and 70.1%, respectively.…”

Section: Discussionmentioning

confidence: 99%

Viral pathogens associated with acute lower respiratory tract infections in children younger than 5 years of age in Bulgaria

et al. 2018

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Acute lower respiratory infections (ALRIs) are a leading cause of morbidity and hospital admissions in children. This study aimed to determine the viral etiology of these infections in children aged < 5 years during three successive epidemic seasons in Bulgaria. Nasopharyngeal and throat specimens were collected from children with bronchiolitis and pneumonia during the 2015/ 2016, 2016/2017, and 2017/2018 seasons. The viral etiology was determined by individual real-time PCR assays against 11 respiratory viruses. Of the 515 children examined, 402 (78.1%) were positive for at least one virus. Co-infections with two and three viruses were found in 64 (15.9%) of the infected children. Respiratory syncytial virus (RSV) was the predominant pathogen (37.5%), followed by rhinoviruses (13.8%), metapneumovirus (9.1%), adenoviruses (7%), bocaviruses (7%), influenza A(H1N1)pdm09 (4.9%), A(H3N2) (4.3%), type B (4.1%), and parainfluenza viruses 1/2/3 (2.9%). RSV-B were more prevalent than RSV-A during the three seasons. At least one respiratory virus was identified in 82.6% and 70.1% of the children with bronchiolitis and pneumonia, respectively. Respiratory viruses, especially RSV, are principal pathogens of ALRIs in children aged < 5 years. Diagnostic testing for respiratory viruses using molecular methods may lead to the reduced use of antibiotics and may assist in measures to control infection.

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Section: Discussionmentioning

confidence: 99%

Viral pathogens associated with acute lower respiratory tract infections in children younger than 5 years of age in Bulgaria

et al. 2018

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“…There were no differences in hospitalization time and mechanical ventilation needs among RSV+ patients and Adenovirus+ in the nasopharyngeal secretion (Ferone, 2014).…”

Section: Clinical Aspectsmentioning

confidence: 78%

“…Fever was found in 70,2% of hospitalized children for LRTI by RSV, proving to be a frequently sign. Temperatures upper to 39° C were found in 23,1% of children (Ferone, 2014).…”

Section: Clinical Aspectsmentioning

confidence: 94%

“…Cough, tachypnea, and wheezing were the most common clinical signs described in children with lower respiratory tract infection (LRTI) (Ferone 2014, Wright & Piedimonte 2011, Thomazelli 2007, Diniz 2005. Other studies showed shortness of breath (Salomão Júnior et al 2011) and cyanosis (Riccetto et al 2006) were more frequently in RSV positive patients than RSV negative.…”

Section: Clinical Aspectsmentioning

confidence: 99%

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Respiratory Syncytial Virus: From Discovery to Treatment

Chong-Silva¹

2014

VR&R

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To review the epidemiology, identifi cation, clinical patterns and treatment of respiratory syncytial virus infection. Raised available studies in the MEDLINE database using the keywords respiratory syncytial virus, respiratory infection, bronchiolitis and indirect immunofl uorescence in international studies since 1980. Respiratory Syncytial Virus (RSV) was fi rst time isolated in 1956 and became the most frequently agent found, especially in the lower respiratory tract of children. It is responsible for signifi cant morbidity and mortality in children younger than 18 months with risk factors such as prematurity and heart disease. It shows well-defi ned distribution along the year. Histopathology, immunohistochemistry and standardized molecular techniques to identify the virus have been described. Th e specifi c treatment of RSV infection is still limited. Antiviral agents as ribavirin showed limited eff ectiveness and restricted to use in a few patients with severe heart disease. Vaccines needs further studies before marketed. Humanized monoclonal antibody -palivizumab -is safe, well tolerated and the most cost-eff ective when used in children at risk for severe RSV infection. Th e high rate of children hospital admissions by RSV infection is a public health issue. Treatment is yet supportive and non specifi c according to severity. Epidemiologic surveillance, routine virus identifi cation and acessibility to health centers are the key points to control infection by this virus.

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“…Other parts of the world reported different values like Kenya 14% [23], Korea 10.3% [24], Australia 7.3% [25], and Peru 6.2% [26]. In contrast, a high incidence of HAdVs was recorded of 83.5% in Taiwanese children with respiratory tract infections [27]. Table 1.…”

Section: Resultsmentioning

confidence: 96%

Molecular Diagnosis of Human Adenovirus in Children with Upper Respiratory Tract Infections

Khalaf¹,

Fadhil²,

Auf³

et al. 2017

IOSRJPBS

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Clinical and epidemiological aspects related to the detection of adenovirus or respiratory syncytial virus in infants hospitalized for acute lower respiratory tract infection

Cited by 6 publications

References 25 publications

Viral pathogens associated with acute lower respiratory tract infections in children younger than 5 years of age in Bulgaria

Viral pathogens associated with acute lower respiratory tract infections in children younger than 5 years of age in Bulgaria

Respiratory Syncytial Virus: From Discovery to Treatment

Molecular Diagnosis of Human Adenovirus in Children with Upper Respiratory Tract Infections

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