Clinical and epidemiological aspects of a hepatitis E outbreak in Bangui, Central African Republic

Goumba, Alice I; Konamna, Xavier; Komas, Narcisse

doi:10.1186/1471-2334-11-93

Cited by 37 publications

(36 citation statements)

References 38 publications

(39 reference statements)

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“…Turkey is a country in the European Union, and socioeconomic conditions there are better than those in the community where this study was done. Goumba et al [16] found a prevalence rate of 78% during an epidemic of HEV infection in Bangui, Central African Republic. The prevalence of hepatitis E in an epidemic period would obviously be higher than in a non-epidemic period.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence and predictors of hepatitis E infection in Nigerian children

Ekanem

Ikobah

Okpara

et al. 2015

J Infect Dev Ctries

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Introduction: Hepatitis E is a hepatotropic virus transmitted through the fecal-oral route and is prevalent in developing countries where sanitation is still a public health issue. There is no epidemiological data about this virus in Nigerian children. All the existing studies are hospital based, with obvious limitations. This study was conducted to establish the seroprevalence and predictors of viral hepatitis E antibody in children in Akpabuyo Local Government Area of Cross River State, Nigeria. Methodology: This was a community-based, cross-sectional study. A multi-staged sampling technique was used to select ten communities from which 406 children were recruited. The study period was April to June 2012. A structured interviewer-administered questionnaire was used for data collection. Blood samples were screened for anti-HEV IgG antibody using the enzyme-linked immunoassay technique. Multivariate logistic regression was used to identify factors that independently predicted the occurrence of the anti-HEV IgG antibody. A p value of < 0.05 was considered significant. Results: The seroprevalence rate of anti-HEV IgG antibody was 7.7% (95% CI = 5.1-10.3). The study population mainly (94.1%) comprised the lower social class. Levels of social amenities in these communities were generally poor, with virtually no piped water and modern sewage disposal systems. After multivariate analysis, the predictor of infection was the duration of residence in the study communities. Conclusions: HEV infection was prevalent in the study population. Educational campaigns and provision of good sewage disposal and piped water are of high necessity.

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Section: Discussionmentioning

confidence: 99%

Seroprevalence and predictors of hepatitis E infection in Nigerian children

Ekanem

Ikobah

Okpara

et al. 2015

J Infect Dev Ctries

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“…HEV outbreaks have been reported from 14 countries: Egypt, 66 Kenya, 67,68 Sudan and South Sudan, [69][70][71][72][73][74][75][76] Central African Republic (CAR), [77][78][79] Uganda, [80][81][82][83][84] Chad, 73,76,[85][86][87][88][89] Republic of Djibouti, 90 Algeria, 85,86,89,91 Namibia, 92,93 Morocco, 94,95 Somalia, 96,97 Ethiopia, 98 South Africa, 99 and Cameroon 100 (Fig. 2 and Table S2).…”

Section: Africamentioning

confidence: 99%

The global burden of hepatitis E outbreaks: a systematic review

Hakim

Wang

Bramer

et al. 2016

Liver International

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Hepatitis E virus (HEV) is responsible for repeated water-borne outbreaks since the past century, representing an emerging issue in public health. However, the global burden of HEV outbreak has not been comprehensively described. We performed a systematic review of confirmed HEV outbreaks based on published literatures. HEV outbreaks have mainly been reported from Asian and African countries, and only a few from European and American countries. India represents a country with the highest number of reported HEV outbreaks. HEV genotypes 1 and 2 were responsible for most of the large outbreaks in developing countries. During the outbreaks in developing countries, a significantly higher case fatality rate was observed in pregnant women. is reported in the population of pregnant women after infection with genotype 1.

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“…50 In addition to this outbreak, laboratory-confirmed outbreaks have occurred in Chad (1983Chad ( -1984 involving French soldiers, 51 and among natives of Mostaganem, Algeria, during 1979-1980. 52 Since 2000, outbreaks have occurred in Central African Republic, 53,54 Chad, 55 Democratic Republic of Congo, 56 Sudan, 57 and Uganda. 58 Several of these outbreaks have occurred in refugee camps in Uganda 59 and Darfur, Sudan.…”

Section: Africamentioning

confidence: 99%

Epidemiology of Hepatitis E in Low- and Middle-Income Countries of Asia and Africa

et al. 2013

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Hepatitis E is an acute, viral hepatitis primarily transmitted through the fecal-oral route. The first major epidemic of hepatitis E virus (HEV) was reported in 1955 in Delhi, India. Since that time, numerous epidemics have been reported across the low- and middle-income countries in Asia and Africa. Even in the absence of large-scale outbreaks, hepatitis E is an important cause of clinical hepatitis. Serologic studies across Asia and Africa show a high prevalence of anti-HEV antibodies. Interest in hepatitis E has increased over the last two decades. However, there are many unanswered questions about the epidemiology of hepatitis E, including a low clinical illness rate in children and the high case fatality rate in pregnant women. Widespread usage of a hepatitis E vaccine may serve to relieve the burden of HEV disease in low- and middle-income countries in Africa and Asia.

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Clinical and epidemiological aspects of a hepatitis E outbreak in Bangui, Central African Republic

Cited by 37 publications

References 38 publications

Seroprevalence and predictors of hepatitis E infection in Nigerian children

Seroprevalence and predictors of hepatitis E infection in Nigerian children

The global burden of hepatitis E outbreaks: a systematic review

Epidemiology of Hepatitis E in Low- and Middle-Income Countries of Asia and Africa

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