Clinical and epidemiological analysis of keloids in Chinese patients

Abstract

Keloids are common abnormally raised fibroproliferative lesions that can occur following even minor cutaneous trauma. There are limited data on Chinese patients with keloids, and the purpose of our study was to investigate the clinical and epidemiological features of keloids in Chinese patients. Assessment was performed by unified, designed questionnaires. A total of 715 patients were enrolled and statistical analysis and heritability were performed using EPI INFO 6.0, SPSS13.0 and Falconer's method. Keloids occurred typically between the ages of 10 and 30 years, and the mean age of initial onset was 21.14 ± 13.45 years in females and 22.55 ± 11.36 years in males. The difference in the mean age of onset was not significant between males and females (p > 0.05). A greater severity of keloids was observed in the positive history family group than in the negative history family group, and this difference was statistically significant (χ (2) = 10.889, p < 0.05). The formation of keloids in multiple anatomical sites was found to be significant in the positive family history group. This difference was statistically significant (χ (2) = 15.47, p < 0.001). The prevalence of keloids in first-, second- and third-degree relatives of the proband with keloids was 7.62, 0.38 and 0.035 %, respectively. These results were higher than those in controls and the difference of the prevalence rates of first- and second-degree relatives between probands and controls was significant (χ (2) = 224.63 and 12.078, respectively, p < 0.001). The heritability of keloids in first-, second- and third-degree relatives was 72.45, 40.55 and 17.07 %, respectively. Our findings revealed that the most severe forms of keloids were observed in the probands with positive family history, and the heritability in first-degree relatives of probands was 72.45 %. It is certain, therefore, that genetic factors play a role in the hereditary composition of keloids.

The dermatology life quality index as a means to assess life quality in patients with different scar types

“…Patients often showed a positive family history for keloids (19.7%) as is common with this affliction and keloids developing in the wake of severe acne. 25 Apart from the physiological scar group and the self-harm scar group the gender distribution of our patient clientele appeared relatively balanced indicating no significant differences in the need for scar treatment between different genders. However, the size of our patient groups limits our ability to draw further conclusions in this regard.…”

Pharmacologic inhibition of JAK-STAT signaling promotes hair growth

“…Keloid lesions show increased IL-4/IL-13 signaling and respond to Th2-targeting dupilumab therapy Editor Keloids are benign growths representing a disrupted wound healing process involving abnormal collagen proliferation. Keloids are most prevalent in African American (AA) 1 and Asian populations, 2 and greatly impact quality of life. 3 Keloids show high recurrence rates and current therapies (intralesional steroids, bleomycin, surgical excision, etc.)…”

“…The effectiveness of long-pulsed Nd:YAG laser in the treatment of venous lakes lies in the fact that its 1064 nm wavelength is preferentially absorbed by methemoglobin and has deep surface penetration of 4-7 mm. [2][3][4][5] Its photocoagulating effect allows therefore the specific targeting of the venous tissue, decreasing the possibility of relapse, and presents sufficient penetration for the treatment of deep-seated lesions. Several types of lasers have been used for the treatment of venous lakes of the lips and vascular malformations of the oral mucosa, including diode laser, 6 pulse-dye laser 7 and argon laser.…”

Reconstruction of a large defect of the female chest following keloid excision with use of the rectus abdominis myocutaneous flap

“…They often occur epidemiologically in young people, especially in females. [6,7] Keloids frequently form on the chest, shoulder, and lower mandible of the face secondary to acne.…”