Clinical and Epidemiologic Characteristics of Human Bocavirus in Danish Infants

Linstow, Marie‐Louise von; Høgh, Mette; Høgh, Birthe

doi:10.1097/inf.0b013e3181757b16

Cited by 103 publications

(118 citation statements)

References 29 publications

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“…21,27,28,64 Studies of nasopharyngeal samples have shown persistence of HBoV1 DNA for several months. [65][66][67][68] HBoV1 seroprevalence ranges from 25% in infants younger than 1 year to 93% and 100% in children of 3 (ref. 28) to 7 (ref.…”

Section: Discussionmentioning

confidence: 99%

“…Other reasons for PCR negativity may be the short duration of HBoV1 viremia, as well as the fact that these children may not have had respiratory infections due to their separation from other children (especially day-care) during the chemotherapy and HSCT. 66 In this study the incidences of B19V, PARV4 and HBoV1 viremias were evaluated using quantitative real-time PCR techniques in a pediatric HSCT cohort. One-third of the patients were PCR positive for B19V without correlation with clinical symptoms (including anemia).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Human parvoviruses B19, PARV4 and bocavirus in pediatric patients with allogeneic hematopoietic SCT

Rahiala

Koskenvuo

Norja

et al. 2013

Bone Marrow Transplant

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Among the immunocompetent, infections with parvovirus B19 (B19V) and human bocavirus (HBoV) 1 range clinically from asymptomatic to severe, while following allogeneic hematopoietic SCT (HSCT) B19V can cause a persistent severe illness. The epidemiology and clinical impact of HBoV1 and the other emerging parvovirus 4 (PARV4) among immunocompromised patients have not been established. To determine the occurrence and clinical spectrum of B19V, PARV4 and HBoV1 infections, we performed a longitudinal molecular surveillance among 53 allogeneic HSCT recipients for pre-and post-HSCT DNAemias of these parvoviruses. Quantitative real-time PCR showed B19V DNA in sera of 16 (30%) patients, at mean levels of 4.6 Â 10 3 , 9.9 Â 10 7 , 1.1 Â 10 10 and 1.6 Â 10 2 B19V DNA copies/mL pre-HSCT (9/53), and at 1 (6/53), 2 (4/53) and 3 months (1/25) post HSCT, respectively. However, no clinical manifestation correlated with the presence of B19V viremia. All B19V sequences were of genotype 1. None of the sera investigated contained PARV4 or HBoV1 DNAs. Our data demonstrate B19V viremia to be frequent among pediatric allogeneic HSCT recipients, yet without apparent clinical correlates. PARV4 or HBoV1 viremias were not seen in these immunocompromised patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Human parvoviruses B19, PARV4 and bocavirus in pediatric patients with allogeneic hematopoietic SCT

Rahiala

Koskenvuo

Norja

et al. 2013

Bone Marrow Transplant

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“…Data from the present study also support the notion that HRV infection is common among the human population. HBoV pathogenesis has been a recent subject of contention; a birth cohort longitudinal study of Danish children detected HBoV frequently in both symptomatic and asymptomatic infants (3,14). In the present study, the pathogenic potential of HBoV in infants with no underlying diseases was unclear.…”

mentioning

confidence: 61%

Longitudinal Study on Respiratory Viral Co-Infections in the Presence or Absence of Clinical Manifestation in Infants Aged 0–2 Years

et al. 2014

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SUMMARY:We conducted a long-term follow-up study between December 2005 and February 2007 on 4 immunocompetent infants, who repeatedly presented with respiratory symptoms, using PCR-based techniques targeting 14 viruses related to acute respiratory tract infection. Of 38 specimens, 30 were collected from symptomatic infants and 8 were collected when respiratory symptoms were absent. Overall, one or more respiratory viruses were detected in 94.7z (36/38) of the specimens. Of the 36 PCR-positive specimens, 77.8z (28/36) were positive for more than one virus. Most of these co-infections were double infections (55.6z or 20/36). Of note, co-infections with 4 and 3 viruses were observed in 3 (8.3z or 3/36) and 5 (13.9z or 5/36) specimens, respectively. Of the 8 specimens collected from the 4 infants when apparent respiratory symptoms were absent, 7 (87.5z) were positive for respiratory viruses. Respiratory viral co-infections were also frequent and found in 5 of the specimens (62.5z). However, apparent correlation between disease severity and co-infection was undetectable due to the limit of the number of cases studied. Taken together, this longitudinal study revealed that respiratory viral co-infections were not infrequent in infants aged 0-2 years, regardless of the presence of respiratory symptoms (62.5-77.8z).

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“…In one of study, Caccia et al 18 reported that HBoV positivity was found in children with respiratory infections who had underlying risk factors as heart disease. In another study, maternal smoking and being born in winter season were found to be associated with HBoV infection 19 .…”

Section: Discussionmentioning

confidence: 99%

İstanbul’da human bocavirüs enfeksiyonu

Demirci¹,

Akın²,

Midilli³

et al. 2016

Cukurova Medical Journal (Çukurova Üniversitesi Tıp Fakültesi Dergisi)

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Clinical and Epidemiologic Characteristics of Human Bocavirus in Danish Infants

Abstract: Asymptomatic carriage of HBoV is common in infants <1 year of age, and an HBoV-positive test result does not imply that HBoV is the cause of the illness.

Cited by 103 publications

References 29 publications

Human parvoviruses B19, PARV4 and bocavirus in pediatric patients with allogeneic hematopoietic SCT

Human parvoviruses B19, PARV4 and bocavirus in pediatric patients with allogeneic hematopoietic SCT

Longitudinal Study on Respiratory Viral Co-Infections in the Presence or Absence of Clinical Manifestation in Infants Aged 0–2 Years

İstanbul’da human bocavirüs enfeksiyonu

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Clinical and Epidemiologic Characteristics of Human Bocavirus in Danish Infants

Abstract: Asymptomatic carriage of HBoV is common in infants <1 year of age, and an HBoV-positive test result does not imply that HBoV is the cause of the illness.

Cited by 103 publications

References 29 publications

Human parvoviruses B19, PARV4 and bocavirus in pediatric patients with allogeneic hematopoietic SCT

Human parvoviruses B19, PARV4 and bocavirus in pediatric patients with allogeneic hematopoietic SCT

Longitudinal Study on Respiratory Viral Co-Infections in the Presence or Absence of Clinical Manifestation in Infants Aged 0&ndash;2 Years

İstanbul’da human bocavirüs enfeksiyonu

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Longitudinal Study on Respiratory Viral Co-Infections in the Presence or Absence of Clinical Manifestation in Infants Aged 0–2 Years