Clinical and endocrine responses to treatment with deslorelin acetate implants in ferrets with adrenocortical disease

Wagner, Robert A.; Piché, Claude A.; Jöchle, W.; Oliver, Jack W.

doi:10.2460/ajvr.2005.66.910

Cited by 64 publications

(43 citation statements)

References 12 publications

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“…Rosenthal and Peterson, 1996). Some of these hormones might have an effect on the behaviour of the affected ferret and it is mentioned that ferrets with hyperadrenocorticism are indeed more aggressive and that these symptoms can be decreased by using a GnRH agonist (Wagner et al, 2005). In some other species, androstenedione is also considered to elevate aggressive behaviour (Swiss-Webster mice: Luttge and Hall, 1973;golden hamster: Payne, 1974).…”

Section: Discussionmentioning

confidence: 99%

The effects of surgical and chemical castration on intermale aggression, sexual behaviour and play behaviour in the male ferret (Mustela putorius furo)

Vinke

Deijk

Houx

et al. 2008

Applied Animal Behaviour Science

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The ferret (Mustela putorius furo) has become an increasingly popular pet animal, yet little is known about their behaviour and welfare. Inter-and intra-specific aggression and the intense musky scent are the two main reasons why male ferrets are normally surgically castrated. However, it is this neutering that is thought to play an important role in the development of hyperadrenocorticism, a hyperfunctioning of the adrenal cortex due to neoplastic changes, a common disease in domestic ferrets. An alternative to surgical castration might be the slow releasing GnRH agonist deslorelin implant (chemical castration).The present study aimed to examine the effects of the deslorelin implant and surgical castration on the occurrence of intermale aggression, sexual behaviour and play behaviour in male ferrets. Therefore, 21 male domestic ferrets received either an implant containing deslorelin (n = 7), a placebo implant (n = 7), or were surgically castrated (n = 7).Our data showed that: (1) chemical castration with the GnRH agonist deslorelin results in a decrease in the occurrence of aggressive behaviour between male ferrets both in the presence and absence of a receptive female. In addition, our data showed that a deslorelin castration had more effect on the reduction of aggression than surgical castration; (2) sexually motivated behavioural patterns were reduced in the deslorelin and surgical castrated group in the male-female confrontation; (3) the deslorelin group, and to a lesser extent the surgically castrated group, had a higher incidence of play behaviour in comparison to intact males in the intermale confrontation tests. Author's personal copy for surgical castration, and may even be preferred due to the serious medical problems associated with surgical castration in ferrets. Especially the increase of play behaviour might be indicative for an improved welfare of the ferrets. #

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Section: Discussionmentioning

confidence: 99%

The effects of surgical and chemical castration on intermale aggression, sexual behaviour and play behaviour in the male ferret (Mustela putorius furo)

Vinke

Deijk

Houx

et al. 2008

Applied Animal Behaviour Science

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“…93 A single implant appears to have a significant increase in duration of effect over leuprolide acetate treatment; however, similarly to leuprolide acetate, it does not seem to deter tumor growth or metastasis. 94 Although currently only labeled for ferrets in the United States for ACD, the 4.7-mg implant has also been evaluated to assess contraceptive efficacy. Plasma follicle-stimulating hormone and testosterone concentrations, size of testicles, and spermatogenesis were all suppressed after the use of a deslorelin implant in male ferrets.…”

Section: Other Drugs _______________________________ Deslorelin Acetatementioning

confidence: 99%

Advances in Exotic Mammal Clinical Therapeutics

Hawkins

2014

Journal of Exotic Pet Medicine

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“…This study described that deslorelin significantly reduced serum concentrations of 17 beta-estradiol and progesterone as compared with untreated cows. Wagner et al (2005) reported a study in which 15 ferrets with NHA were subcutaneously treated with a single 3-mg implant of deslorelin acetate. Compared with findings before treatment, vulvar swelling and pruritus were reduced or eliminated completely within two weeks after implant insertion.…”

Section: Discussionmentioning

confidence: 99%

“…Adrenocortical disease has been recognized for almost 20 years as a common disease affecting pet ferrets in the US and in European countries (Hillyer, 1992;Lipman et al, 1993;Rosenthal et al, 1993;Rosenthal, 1997;Weiss and Scott, 1997;Wheler and Kamieniecki, 1998;Weiss et al, 1999;Schoemaker et al, 2000Schoemaker et al, , 2002Schoemaker et al, , 2004Wagner et al, 2001Wagner et al, , 2005Schoemaker, 2003;Bielinska et al, 2006). It has been supposed that competent cells in the ferret adrenal cortex undergo neoplastic transformation and adopt features of gonadal steroidogenic cells in response to the hormonal changes that follow gonadectomy.…”

mentioning

confidence: 99%

Deslorelin treatment of hyperoestrogenism in neutered ferrets (Mustela putorius furo): a case report

2009

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Hyperoestrogenism causing progressive alopecia in neutered ferrets may be induced by ovarian remnant syndrome (ORS) and nodular hyperplasia of the adrenocortex (hyperadrenocorticism, NHA). The objective of the study was to determine whether a slow-release implant of a gonadotropin releasing hormone (GnRH) analogue, deslorelin, has any value in therapy of hyperoestrogenism of adrenocortical origin (NHA). Three supposed cases of NHA with alopecia and other clinical signs of hyperoestrogenism (n = 2 spayed females in oestrous and n = 1 castrated male) were treated with a subcutaneous implant of 4.7 mg deslorelin acetate. Blood samples were collected, and plasma levels of estradiol (E 2 ) were determined just before, and some weeks after treatment. For realistic monitoring, blood samples for E 2 determination were also taken from intact, healthy (untreated control) females after the beginning of heat (n = 5), or 9-21 days after, with hCG induced ovulation (n = 6), or out of breeding season (n = 3). Before treatment, all three alopecic ferrets showed elevated E 2 concentrations (99.45-139.9 pmol/l) similar to the untreated control females in oestrous (61.6-123.02 pmol/l) (P = 0.229). Some weeks after the deslorelin administration, the hair of these ferrets began to grow again and the elevated E 2 concentrations significantly decreased compared to the pre-treatment values (P = 0.035). E 2 concentrations reached the basal level (12.89-16.08 pmol/l) typical for that of the untreated control females in anoestrus or in luteal phase (12.0-30.58 pmol/l) (P = 0.137). All treated ferrets were examined again 19-21 months after implant insertion (the implant still being present) and all of them had normal hair and were clinically healthy. These observations prove that deslorelin can suppress the E 2 production of NHA, and is therefore a useful tool in the therapy of hormonal alopecia neutered ferrets.

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Clinical and endocrine responses to treatment with deslorelin acetate implants in ferrets with adrenocortical disease

Cited by 64 publications

References 12 publications

The effects of surgical and chemical castration on intermale aggression, sexual behaviour and play behaviour in the male ferret (Mustela putorius furo)

The effects of surgical and chemical castration on intermale aggression, sexual behaviour and play behaviour in the male ferret (Mustela putorius furo)

Advances in Exotic Mammal Clinical Therapeutics

Deslorelin treatment of hyperoestrogenism in neutered ferrets (Mustela putorius furo): a case report

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