Clinical and electrophysiological study of the peripheral nervous system in the elderly

Bouché, P; Cattelin, F; Saint-Jean, Olivier; Léger, Jean‐Marc; Queslati, S.; Guez, David; Moulonguet, A; Brault, Y.; Aquino, J. P.; Simunek, P.

doi:10.1007/bf00838158

Cited by 92 publications

(65 citation statements)

References 27 publications

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“…16 In our study, SNAP amplitudes of median, right ulnar and radial nerves were lower in the older age group as compared to the younger ones. 22 Fujimaki et al in their study also found the similar decrease in SNAP amplitude of the median, ulnar, superficial radial, superficial peroneal and sural nerves with advancing age. 5 This may be due to loss of large nerve fibers in older individuals.…”

Section: Discussionmentioning

confidence: 54%

“…10 Also, in our study smaller CMAP amplitude was significantly related to advancing age. 22 Kurokawa et al in their study found lower CMAP amplitude in the older age as compared to the younger ones, 11 however, the CMAP duration did not differ among the two age groups. In contrast to their study, our study showed statistically significant effect of age on CMAP duration.…”

Section: Discussionmentioning

confidence: 83%

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Nerve Conduction study in healthy individuals, a preliminary age based study

Thakur

Paudel

Jha

2012

Kathmandu Univ. Med. J.

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 83%

Nerve Conduction study in healthy individuals, a preliminary age based study

Thakur

Paudel

Jha

2012

Kathmandu Univ. Med. J.

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“…Most common was a reduced/absent ankle jerk (67%) followed by muscle weakness (55%) and reduced pinprick sensation (52%). However, similar abnormal leg neurological findings may be encountered in asymptomatic elderly people without reflecting pathology [22]. Hence, clinical findings on the whole are not specifically diagnostic.…”

Section: Discussionmentioning

confidence: 99%

The Clinical Syndrome Associated with Lumbar Spinal Stenosis

Goh¹,

Khalifa

Anslow

et al. 2004

Eur Neurol

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Lumbar spinal stenosis is well defined in patho-anatomical terms but its clinical features are heterogeneous. We carried out a comprehensive retrospective review of the clinical features, radiological changes and outcome of 75 patients with radiologically diagnosed lumbar spinal stenosis in order to define its clinical spectrum. The presenting complaints were of weakness, numbness/tingling, radicular pain and neurogenic claudication in almost equal proportions. The commonest symptom was numbness or tingling of the legs. Neurogenic claudication eventually occurred in only 61%. Ninety-three per cent showed abnormalities on neurological examination, but these were generally mild with reduced ankle jerks being commonest. Imaging of the lumbar spine showed that moderate to severe central spinal stenosis correlated with complaints of weakness and abnormal motor power on clinical examination. Patients were reviewed at a mean of 4 years after diagnosis and 65% had undergone surgical decompression; this was not a prospective comparison of different treatment modalities. Overall, a third of patients felt that their symptoms had improved while a quarter felt that they had worsened. More than half had satisfactory neurological function at the time of review. Thirty-nine per cent of those treated surgically, and 25% of those managed conservatively, reported improved symptoms. A poorer functional status at review correlated with complaints of motor weakness and associated comorbid disease. Degenerative lumbar stenosis is a clinically heterogeneous neurological disorder of the lower limbs in the elderly with variable longer-term outcome. A high index of suspicion is required and neuroimaging should be obtained to confirm the diagnosis.

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“…To identify how these degenerative changes occur, several studies of human and rodent have compared electrophysiological and anatomical properties of young and aged neurons, peripheral nerves and target tissues. In humans, electrophysiological measures have found lower nerve conduction velocity in older individuals, suggesting impairment in axon structure and function [9,37]. Analysis of nerve fibers in aging mice from 20 months of age onward, showed both myelinated and unmyelinated fibers to be reduced in number, which in the very old mouse (33 months) approaches 50% loss [13].…”

Section: Introductionmentioning

confidence: 99%

Reduced thermal sensitivity and Nav1.8 and TRPV1 channel expression in sensory neurons of aged mice

Wang

Davis

Zwick³

et al. 2006

Neurobiology of Aging

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Sensory neurons in aging mammals undergo changes in anatomy, physiology and gene expression that correlate with reduced sensory perception. In this study we compared young and aged mice to identify proteins that might contribute to this loss of sensation. We first show using behavioral testing that thermal sensitivity in aged male and female mice is reduced. Expression of sodium channel (Nav1.8 and Nav1.9) and transient receptor potential vanilloid (TRPV) channels in DRG and peripheral nerves of young and old male mice was then examined. Immunoblotting and RT-PCR assays showed reduced Nav1.8 levels in aged mice. No change was measured in TRPV1 mRNA levels in DRG though TRPV1 protein appeared reduced in the DRG and peripheral nerves. The GFRα3 receptor, which binds the growth factor artemin and is expressed by TRPV1-positive neurons, was also decreased in the DRG of aged animals. These findings indicate that loss of thermal sensitivity in aging animals may result from a decreased level of TRPV1 and Nav1.8 and decreased trophic support that inhibits efficient transport of channel proteins to peripheral afferents.

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Clinical and electrophysiological study of the peripheral nervous system in the elderly

Cited by 92 publications

References 27 publications

Nerve Conduction study in healthy individuals, a preliminary age based study

Nerve Conduction study in healthy individuals, a preliminary age based study

The Clinical Syndrome Associated with Lumbar Spinal Stenosis

Reduced thermal sensitivity and Nav1.8 and TRPV1 channel expression in sensory neurons of aged mice

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