Clinical and EEG features of acute intrathecal baclofen overdose

Sauneuf, Bertrand; Totouom, H. Kamga; Savary, Benoît; Varin, Laurent; Dupeyrat, Julien; Ramakers, Sophie; Hanouz, Jean‐Luc

doi:10.1016/j.clineuro.2011.07.028

Cited by 13 publications

(12 citation statements)

References 9 publications

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“…ITB overdose can mimic symptoms associated with sepsis, intracranial hemorrhage, hypoglycemia, Cushing's triad, electrolyte imbalance, and seizure disorder . Overdose symptoms may include nausea and vomiting, dizziness, respiratory depression, hypothermia, rostral progression of hypotonia, and somnolence that have advanced to seizures and coma requiring ventilatory support . Several authors have reported EEG findings in ITB overdose, specifically an increase of slow wave activity and periodic shape waves associated with epileptiform discharges .…”

Section: Diagnostic Evaluation Processmentioning

confidence: 99%

Best Practices for Intrathecal Baclofen Therapy: Troubleshooting

Saulino

Anderson

Doble

et al. 2016

Neuromodulation: Technology at the Neural Interface

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Section: Diagnostic Evaluation Processmentioning

confidence: 99%

Best Practices for Intrathecal Baclofen Therapy: Troubleshooting

Saulino

Anderson

Doble

et al. 2016

Neuromodulation: Technology at the Neural Interface

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“…The outcome of baclofen intoxication is generally good, and a large number of studies have reported a complete recovery of patients even after episodes of coma [41,42,43,44,45,46,47,48,49,50,51]. However, baclofen intoxication can be life-threatening, and fatal cases of baclofen intoxication have also been described [40,52].…”

Section: Pharmacological Features Of Baclofenmentioning

confidence: 99%

Efficacy and Tolerability of Baclofen in Substance Use Disorders: A Systematic Review

Agabio¹,

Preti

Gessa

2013

Eur Addict Res

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Background: It has been reported that baclofen, a drug used in the treatment of spasticity, reduces the severity of withdrawal symptoms and substance use disorders (SUDs) for some psychoactive drugs. Aims and Methods: To evaluate the effectiveness and safety of baclofen in the treatment of withdrawal syndrome and/or SUDs, providing (1) an outline of its pharmacological features; (2) a summary of studies that have suggested its possible effectiveness in the treatment of SUDs, and (3) a review of randomized, controlled trials (RCTs) on baclofen and SUDs. Results: Baclofen tolerability is generally considered to be good. Eleven RCTs investigated its effectiveness in the treatment of SUDs. Of these, 5 RCTs found that baclofen is effective, 5 RCTs found that it is ineffective and the results of 1 RCT were not appreciable because it did not achieve the preplanned level of participation. Conclusions: The number of RCTs on baclofen and SUDs is still low, and their results are divergent. Further RCTs should be undertaken, particularly with higher doses of baclofen. Its administration may be suggested in patients who fail to respond to other approved drugs or who are affected by liver disease that prevents their administration, or in patients affected by SUDs for which no approved drugs are available. Treatment should be conducted under strict medical supervision.

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“…The usual fi nd ing dur ing intrathecal baclofen overdose is a reversible increase of slow wave activity, with periodic shape waves as sociated with periodic epileptic discharges [8]. Other abnormalities such as triphasic waves and burst suppressions have been described in cases of oral overdose [1,9]. Our patient was found at a bus stop in generalized convulsion and coma.…”

Section: Discussionmentioning

confidence: 63%

“…It binds to presynaptic GABA-B receptors within the brainstem and dorsal horn of the spinal cord. It acts by restrict ing calcium infl ux into the presynaptic nerve terminal, thereby reduc ing release of presynaptic trans mitters [1]. Baclofen is used in the treatment of muscle spasticity in patients w i t h s p i n a l o r c e r e b r a l d i s o r d e r s [ 2] .…”

Section: Discussionmentioning

confidence: 99%