Clinical and economic substantiation of technologies of regulation of energy metabolism from the viewpoint of systemic pharmacodynamics

Abstract

The data of experimental and clinical evaluation and the results of pharmacoeconomic analysis of the effects of regulators of energy metabolism attest to their multiple pharmacodynamics during correction of pathological processes in systems differing by their structure, function, and metabolism. Polyorgan energy protection of regulators of energy metabolism improves organism's resistance, accelerates sanogenesis, and reduces the costs per unit of clinically significant effect. Here we discuss the creation of pharmacotherapeutic technologies based on principles of bioenergetic pharmacology. Sciences. Address for correspondence: vkh@pharm.tsu.ru. V. A. Khazanov Efforts of classical pharmacology are traditionally aimed at the search for preparations correcting certain pathogenetic elements and at the development of "pathogenetic schemes" of pharmacotherapy of various diseases. Dysregulation of functions, accumulation of entropy, and development of energy deficiency are considered to be typical pathological processes [5]. Most drugs are xenobiotics; they can draw away considerable energy resources of the organism for their biotransformation and elimination and can disturb the function of cell energyproducing systems. This can complicate treatment and delay sanogenesis.In healthy organism, energy processes are balanced according to demands for optimal functioning of organs and systems. Optimization of utilization of energy resources in the organism and regulation of their supply and distribution in favor of most needing tissues and organsis are a way for natural (not xenobiotic) counteraction of entropy and dysregulation promoting recovery of functions and convalescence. Systemic approach to multidimensional energy protection was realized in the form of pharmacological construction of regulators of energy metabolism (REM) [11][12][13][14]. The idea of a new class of drugs containing low doses of energy substrates is based on the concept on homeostatic role of mitochondria and principles of bioenergetic pharmacology [4,16]. The pathological process can be thus alleviated via correction of functions of cell energy-producing systems under conditions of energy deficiency [16]. Here we present the results of systemic analysis of clinical and pharmacoeconomic efficiency of REM during treatment of some prevalent diseases as a prerequisite for the creation of new medical technologies characterized by high efficiency and low costs of treatment. MATERIALS AND METHODSSystemic approach to evaluation of the effects of REM was realized though step-by-step clinical and economic analysis of the results of randomized