Clinical and economic analysis of hospital acquired infections in patients diagnosed with brain tumor in a tertiary hospital

Abstract

SummaryObjectives. To analyze the relationship between hospital acquired infections and clinical outcomes, duration of stay, and cost per infectious episode in patients diagnosed with brain tumors in our service.Materials and methods. We conducted a retrospective study on patients diagnosed with brain tumors and admitted to the department of neurosurgery in the Cruces Hospital of the University of the Basque Country between January 1st, 2007 and December 31st, 2007. We collected demographics, responsible pathogens, infection location, length of hospitalization, and costs of various medical and surgical procedures performed.Results. We reviewed 139 patients that accumulated 210 hospital visits. We found 34 episodes of hospital acquired infections (16.25% of patients). The most frequent infections were that of the lower respiratory tract, urinary tract, and surgical site. We found that patients with HAIs had a significantly lower final KPS score (sig <0.01), greater mean cost of stay (17097€, sig.<0.01), and longer length of stay (15.45 days, sig<0.01). We did not find a significant difference in mortality.Conclusions. We found significant association between the presence of HAIs and worse clinical outcomes, higher costs, and longer length of stay. The pathogens responsible and infection locations were similar to existing series in the literature. Although variability in study designs in the literature makes interpretation and comparison of results difficult, measures to prevent these complications can improve quality of care and reduce costs.KEY WORDS. Brain neoplasms. Infection. Costs. Análisis clínico económico de las infecciones nosocomiales en los pacientes diagnosticados de tumoración cerebral en un hospital terciario ResumenObjetivos. Analizar la relación entre la presencia de infección nosocomial y el resultado clínico final, la duración de la estancia y el coste del episodio en los pacientes diagnosticados de tumoración cerebral en nuestro servicio. Material y método. Realizamos un estudio retrospectivo incluyendo los pacientes ingresados en el Servicio de Neurocirugía del Hospital Universitario de Cruces con diagnostico de tumoración cerebral en el periodo comprendido entre el 1-1-2007 y el 31-12 del 2007. Recogimos variables demográficas, los microorganismos responsables y la localización de las distintas infecciones, el tiempo de ingreso y los costes de los distintos procedimientos médicos y quirúrgicos realizados.Resultados. Recogimos 139 pacientes, que acumularon un total de 210 episodios. Encontramos la presencia de infecciones nosocomiales en 34 episodios (16,25%). La localización mas frecuente fue la respiratoria, seguida del tracto urinario y la infección de herida quirúr-gica. Encontramos unas diferencias significativas en la situación funcional al alta (sig <0.01), el coste medio de los episodios (17097€, sig.<0.01) y en la estancia media (15.45 días, sig.<0.01). No encontramos diferencias significativas con respecto a la mortalidad.Conclusiones. Encontramos asociaciones significativas entre la...

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Influencing factors and burden of hospital-acquired infections among cancer patients

“…general hospital inpatients [2,3]. Only a limited number have evaluated their impact on cancer patients and these studies were often constrained by speci c types of cancer [4][5][6].…”

“…For example, a prospective monitoring case-control study of 448 patients undergoing colorectal cancer surgery in China presented that the total direct economic burden due to HAI was 1,589.30 dollars [5]. While, a retrospective study in Europe on 139 patients diagnosed with brain tumors reported a mean cost 17,097 euros [4] and another previous study in USA on gynecologic tumor estimated the cost 58,000 dollars[6]. Certainly, the economic loss due to HAIs varies in different studies by the region of study, the characteristics of study population, the structure and composition of disease and the types of infection.…”

Relation of Malnutrition and Nosocomical Infections in Cancer Patients in Hospital: An Observational Study

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